2-[2-[4-(7-Chloroquinolin-2-yl)oxyphenoxy]propanoylamino]ethanesulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[2-[4-(7-Chloroquinolin-2-yl)oxyphenoxy]propanoylamino]ethanesulfonic acid
• 化学式: C₂₀H₁₉ClN₂O₆S
• 分子量: 450.9
• InChiKey: FEMGGCCMUQWSPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] THERAPEUTIC AMIDES<br/>[FR] AMIDES THERAPEUTIQUES
  申请人：UNIV WAYNE STATE

  公开号：WO2004004651A2

  公开（公告）日：2004-01-15

  The invention provides compounds of the formula (I) wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.