1,1-二环丙基乙醇 | 18895-50-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,1-二环丙基乙醇
• 英文名称: dicyclopropylmethylcarbinol
• 英文别名: 1,1-Dicyclopropylethanol；1,1-dicyclopropyl-ethanol；1,1-Dicyclopropyl-aethanol；Methyl-dicyclopropyl-carbinol；Dicyclopropyl-methylcarbinol；1,1-Dicyclopropylethan-1-ol
• CAS: 18895-50-6
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: BOYDTXNAECZPAU-UHFFFAOYSA-N

物化性质

• 沸点：
  58 °C(Press: 15 Torr)
• 密度：
  0.9445 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  1,1-二环丙基乙醇 在 ion-exchange resin + form> 、 potassium tert-butylate 作用下， 以 苯 为溶剂， 生成 2',2'-Dichloro-[1,1';1',1'']tercyclopropane
  参考文献：
  名称：

  Preparation and some carbene reactions of 1,1-dicyclopropylethylene

  摘要：

  DOI：

  10.1007/bf00851221
• 作为产物：
  描述：

  双环丙基酮 在 甲基碘化镁 作用下， 生成 1,1-二环丙基乙醇
  参考文献：
  名称：

  The Solvolysis of p-Nitrobenzoates of Certain Cyclopropylcarbinols^1,2

  摘要：

  DOI：

  10.1021/ja01511a016

文献信息

• Synthesis of alkyl methyl ethers and alkyl methyl carbonates by reaction of alcohols with dimethyl carbonate in the presence of tungsten and cobalt complexes
  作者：R. I. Khusnutdinov、N. A. Shchadneva、Yu. Yu. Mayakova

  DOI：10.1134/s1070428014060050

  日期：2014.6

  Alkyl methyl ethers and alkyl methyl carbonates were synthesized by reaction of alcohols with dimethyl carbonate in the presence of tungsten and cobalt carbonyls. Optimal reactant and catalyst ratios, as well as reaction conditions, were found for selective formation of alkyl methyl ethers or alkyl methyl carbonates.

  在醇和羰基钴存在下，通过醇与碳酸二甲酯的反应合成烷基甲基醚和碳酸烷基甲基酯。发现了用于选择性形成烷基甲基醚或碳酸烷基甲基酯的最佳反应物和催化剂比例以及反应条件。
• Markovnikov hydration of vinylcyclopropanes by oxymercuration-demercuration.
  作者：Shinya Nishida、Takashi Fujioka、Nobujiro Shimizu

  DOI：10.1016/s0022-328x(00)84861-5

  日期：1978.8

  Representative vinylcyclopropanes (IaIc) were hydrated in a Markovnikov fashion by oxymercuration-demercuration. Isolated yields of α-cyclopropyl-substituted alcohols were more than 80%. 2,2-Diphenyl-l-vinylcyclopropane (Id) was the only olefin that produced a mixture of the expected alcohol, IId, and a rearranged product III. At 0° C, However, the amount of III was minimal (ca. 6%), and hence the

  代表性的乙烯基环丙烷（IaIc）以马尔可夫尼可夫的方式通过氧化汞-脱汞水合。α-环丙基取代的醇的分离产率超过80％。2，2-二苯基-1-乙烯基环丙烷（Id）是唯一产生预期醇IId和重排产物III的混合物的烯烃。然而，在0°C下，III的量极少（约6％），因此实现了Id的马尔可夫尼科夫水合。通过用硼氢化氘化钠脱汞证明了在III的生成过程中消耗了2摩尔当量的乙酸汞。
• Thienopyrazoles
  申请人：Jurcak Gerald John

  公开号：US20070254937A1

  公开（公告）日：2007-11-01

  Thienopyrazoles of formula I, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

  公式I的噻唑并吡嗪化合物，其制备方法，包含这些化合物的制药组合物以及它们在治疗能够通过抑制蛋白激酶来调节的疾病状态中的制药用途，特别是白细胞介素-2诱导的酪氨酸激酶（ITK）的抑制。
• 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
  申请人：Chau Anh

  公开号：US20090075998A1

  公开（公告）日：2009-03-19

  The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

  该发明涵盖了式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗多种疾病或情况引起的疼痛和/或炎症，如骨关节炎，类风湿性关节炎和急性或慢性疼痛。还包括治疗由mPGES-1酶介导的疾病或情况的方法和制药组合物。
• 2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
  申请人：Chau Anh

  公开号：US20070208017A1

  公开（公告）日：2007-09-06

  The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

  本发明涵盖了公式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合成酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病况引起的疼痛和/或炎症，如骨关节炎、类风湿性关节炎和急性或慢性疼痛。还包括治疗由mPGES-1酶介导的疾病或病况的方法和制药组合物。