1,12-二甲氧基-十二烷 | 73120-52-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,12-二甲氧基-十二烷
• 英文名称: 1,12-dimethoxydodecane
• 英文别名: 1,12-Dimethoxy-dodecan；Dimethoxydodecan；α.ω-Dimethoxy-dodecan；Dodecandiol-(1.12)-dimethylaether
• CAS: 73120-52-2
• 化学式: C₁₄H₃₀O₂
• 分子量: 230.391
• InChiKey: CFUFEIWWICPJOZ-UHFFFAOYSA-N

物化性质

• 熔点：
  11.5°C
• 沸点：
  312.39°C (rough estimate)
• 密度：
  0.8563

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,12-二甲氧基-十二烷 在 氢溴酸 作用下， 生成 1,12-二溴十二烷
  参考文献：
  名称：

  Chuit, Helvetica Chimica Acta, 1926, vol. 9, p. 265

  摘要：

  DOI：
• 作为产物：
  描述：

  1-溴-6-甲氧基己烷 在 sodium 、 苯 作用下， 生成 1,12-二甲氧基-十二烷
  参考文献：
  名称：

  Hamaide, Bulletin de la Societe Chimique de France, 1958, p. 306,308

  摘要：

  DOI：

文献信息

• Oxidation of Ethers by NO₃^•Generated from NO₃⁻with Anodic Oxidation
  作者：Tatsuya Shono、Yoshinari Yamamoto、Katsuya Takigawa、Hirofumi Maekawa、Manabu Ishifune、Shigenori Kashimura

  DOI：10.1246/cl.1994.1045

  日期：1994.6

  A radical NO3• generated by anodic oxidation of NO3− was found to be an effective species to the oxidation of ethers to the corresponding carboxylic acids and ketones, and this reaction was successfully applied to the synthesis of dihydrojasmone.

  发现NO3-阳极氧化产生的NO3•自由基是醚类氧化成相应羧酸和酮的有效物质，该反应成功地应用于二氢茉莉酮的合成。
• [EN] BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS, COMPOSÉS BOLAAMPHIPHILES, ET LEURS UTILISATIONS
  申请人：LAUREN SCIENCES LLC

  公开号：WO2016168580A1

  公开（公告）日：2016-10-20

  Bolaamphiphilic compounds are provided according to formula (I); where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.

  根据公式（I），提供了双亲嵌段化合物；其中HG1、HG2和L1如本文所定义。提供的双亲嵌段化合物及其制成的药物组合物可用于将GDNF或NGF输送到动物或人类大脑中。
• FLUORENE COMPOUND
  申请人：Ajinomoto Co., Inc.

  公开号：US20140046022A1

  公开（公告）日：2014-02-13

  Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.

  具有芴骨架的特定化合物在广泛的应用和稳定性方面表现出优越性，可作为液相合成氨基酸和/或肽的保护试剂。
• Fingerprinting a transition-structure guest by a building-block approach with an incremental series of catalytic hosts. Structural requirements for glyme and .alpha.,.omega.-dimethoxyalkane catalyses in N-methylbutylaminolysis and butylaminolysis of 4-nitrophenyl acetate in chlorobenzene
  作者：John C. Hogan、Richard D. Gandour

  DOI：10.1021/jo00027a014

  日期：1992.1

  Glymes, H-(CH2OCH2)n-H, GLM(n), catalyze butylaminolysis of 4-nitrophenyl acetate in chlorobenzene. Values of k(cat)/Oxy, where Oxy is the number of oxygens in the catalyst, increase with oligomer length up to triglyme, GLM(4), and then plateau. Optimal catalysis on a per oxygen basis requires a -(CH2OCH2)4-fragment, which suggests a four-point recognition of the secondary ammonium ion of the zwitterionic tetrahedral intermediate (TI) (J. Org. Chem. 1991, 56, 2821-2826). Dissection of individual structural components and reassembly to the same structure of the complex verifies this model. The following kinetic studies of 4-nitrophenyl acetate in chlorobenzene have accomplished the task: (a) methylbutylaminolysis catalyzed by GLM(n), n = 2-4; (b) methylbutylaminolysis catalyzed by alpha,omega-dimethoxyalkanes, CH3O-(CH2)n-OCH3, DME(n), n = 2-10 and 12; and (c) butylaminolysis catalyzed by DME(n), n = 2-10 and 12. Experiment a has revealed that k(cat)/Oxy is the same for GLM(2)-GLM(4). Optimal catalysis for breakdown of a zwitterionic TI with one ammonium proton only requires a -(CH2OCH2)2- fragment. Experiment b has shown that k(cat)/Oxy is largest for DME(2) with the values for the remaining DMEs 2-2.5-fold lower. A -CH2CH2- is the best spacer between the two oxygens. Thus, bifurcated hydrogen-bond formation between the two oxygens and the one ammonium proton enhances catalysis. Experiment c has revealed that k(cat)/Oxy for DME(2) exceeds the remaining DMEs by 3-3.6-fold, except for DME(8) and DME(10), which have values of k(cat)/Oxy only 1.7-fold slower. DME(8), the carba analogue of GLM(4), likely binds to the two ammonium protons individually with the two oxygens. DME(10) behaves similarly. GLM(4) catalysis of butylaminolysis identifies -(CH2OCH2)4- as an optimal size. DME(8) catalysis confirms this size, although the two catalysts stabilize the two-proton ammonium ion differently. GLM(4) catalyzes butylaminolysis by forming two bifurcated hydrogen bonds. This suggested structure defines the size of the ammonium ion, which agrees with X-ray structural studies of polyether-ammonium complexes. Mechanistic proposals of butylaminolysis of aryl esters require such an ion. The results of this study confirm the structure of the ion in the rate-limiting step. This building-block approach is a method for ''fingerprinting'' ammonium ions in transition structures of ionogenic reactions.
• Lenne,H.-U. et al., Justus Liebigs Annalen der Chemie, 1970, vol. 732, p. 70 - 96
  作者：Lenne,H.-U. et al.

  DOI：——

  日期：——