CANTHATCH WHEAT SEEDS WERE TREATED WITH LINDANE-(14)C (480 PPM) & PLANTED, TOTAL (14)C RESIDUES WERE DETERMINED IN 19-DAY-OLD SEEDLINGS, 1,2,3,5-TETRACHLOROBENZENE WAS IDENTIFIED IN ROOT SAMPLES.
Lindane administered to hen pheasants resulted in tetrachlorobenzene being identified ... as part of the array of metabolites found in eggs and chicks as well as in the body tissues of hens. /Tetrachlorobenzenes/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
副作用
职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒病例。
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Since TeCB's can increase cytochrome p450 levels, ... it appears to induce metabolic enzymes. /This/ induction of microsomal enzyme activity has been shown to enhance the metabolism of a wide variety of drugs, pesticides and other xenobiotics. Exposure to TeCB could therefore result in decreased pharmacologic and/or toxicologic activity of numerous compounds. /In the event/ that chemical agents are metabolized to more active or toxic reactive intermediates ... exposure to TeCB would result in enhanced activity and/or toxicity of these agents. /Tetrachlorobenzenes/
LIVER CONSTITUENTS, CYTOCHROME CONTENTS, & ACTIVITIES OF DRUG-METABOLIZING ENZYMES & DELTA-AMINOLEVULINIC ACID SYNTHETASE WERE EXAM IN RATS TREATED WITH 1,2,3,5-TETRACHLORBENZENE. PHOSPHORUS WAS INCR 91% & HEPATIC GLYCOGEN CONTENT WAS DECR BY TREATMENT.
Three tetrachlorobenzene (TCB) congeners (1,2,3,4-, 1,2,3,5-, and 1,2,4,-) were administered daily by gavage to pregnant Sprague-Dawley rats at levels of 50, 100, or 200 mg/kg from day 6-15 of gestation. Mothers were sacrificed on day 21 of gestation and the pups removed by cesarean section for teratological evaluation. Administration of 1,2,3,4- and 1,2,3,5-TCB failed to alter maternal body weight, organ weights, hematological, or the biochemical parameters. The highest dose level of 1,2,4,5-TCB caused maternal death in 9 of 10 animals. In addition, it induced mixed function oxidases and increased serum cholesterol values at 50 and 100 mg/kg. There was a decrease in the number of fetuses at the highest dose levels of 1,2,3,4- and 1,2,3,5-TCB and at the lowest dose level of the 1,2,4,5- congener. None of the congeners produced any anomalies. There were no treatment-related histopatholgical changes in either the mothers or fetuses. Residues of all three congeners were found in maternal and fetal tissues but generally the amounts of the 1,2,4,5- isomer were about 100 times higher than the other two.
Groups of 15 male and 15 female rats were fed diets containing 0, 0.5, 5.0, 50 or 500 ppm of each of 1,2,3,4- 1,2,3,5- and 1,2,4,5-TCB for 13 weeks. Rats fed 500 ppm 1,2,4,5-TCB exhibited significant increases in liver and kidney weight. Moderate to severe histological changes occurred in the liver and kidney of rats fed the three isomers, but the 1,2,4,5-isomer caused the most severe lesions. 1,2,4,5-TCB accumulated in fat and liver in a dose dependent manner. Results indicate that 1,2,4,5-TCB is the most toxic isomer of the three.
Three tetrachlorobenzene (TCB) congeners (1,2,3,4- 1,2,3,5- and 1,2,4,5-Tetrachlorobenzene were administered daily by gavage to pregnant Sprague-Dawley rats at levels of 50, 100, or 200 mg/kg from day 6-15 of gestation. Residues of all three congeners were found in maternal and fetal tissues but generally the amounts of the 1,2,4,5- isomer were about 100 times higher than the other two.
Photochemistry of polyhaloarenes. 9. Characterization of the radical anion intermediate in the photodehalogenation of polyhalobenzenes
摘要：
The product-determining intermediate in the photodehalogenation of polyhalobenzenes has been characterized by generating excimers and radical anions within a micellar core and by formation of corresponding radical anions by electron transfer from lithium p,p'-di-tert-butylbiphenyl radical anion (LiDBB). The photodechlorination of pentachlorobenzene (1; 254 nm, CH3CN) produces 1,2,3,5-tetrachloro- (2), 1,2,4,5-tetrachloro- (3), and 1,2,3,4-tetrachlorobenzene (4). The regiochemistry of this reaction is compared with that observed in the photodechlorination of 1 in a micellar solution of hexadecyltrimethylammonium bromide (CTAB) with occupancy numbers (n) principally < 2 and greater-than-or-equal-to 2. Further comparisons with photodechlorination of 1 in a micellar CTAB solution (n < 2) in the presence of triethylamine, as well as photodechlorination in CH3CN in the presence of triethylamine, were used to characterize unencumbered radical anions. The regiochemistries observed in photolytic dehalogenations of 1, 2, 1,2,4-trichlorobenzene, and pentafluorobenzene in the presence of triethylamine are in good agreement with those realized in the radical anion fragmentations induced by electron transfer from LiDBB.
Sodiummethoxide reacts with dichlorobenzenes in HMPA to give the chloroanisoles as a result of a SNAr process. Excess MeONa then effects the demethylation of the ethers to give the chlorophenols via an SN2 reaction. With tri- and tetrachlorobenzenes the initially formed chloroanisoles can be dealkylated to chlorophenols or can suffer further substitution to give the chlorodimethoxybenzenes; these
由于S N Ar过程，甲醇钠与HMPA中的二氯苯反应生成氯茴香醚。然后过量的MeONa通过S N 2反应使醚脱甲基，得到氯酚。用三氯苯和四氯苯可以将最初形成的氯茴香醚脱烷基化为氯酚，或者可以进一步取代生成氯二甲氧基苯；它们与过量的MeONa反应，得到氯甲氧基苯酚。在取代基的电子效应的基础上，介绍并讨论了用二，三和四氯苯的各种异构体获得的结果。
Photoreactions of Polyhalobenzenes in Benzene. Formation of Terphenyls
Polychlorobenzenes, polybromobenzenes, and polychloropolybromobenzenes (C6H6−nXn) were photolyzed in benzene solutions; the products were analyzed by the GC/MS method. Both dehalogenation and phenylation were shown to take place competitively, producing (poly)halobenzenes bearing one less halogen atom (C6H7−nXn−1) and (poly)halobiphenyls (C6H6
