1,2,3-丙三羧酸,2-羟基-,混合碳酸氢氢钾碳酸酯和钠 | 94275-80-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 1,2,3-丙三羧酸,2-羟基-,混合碳酸氢氢钾碳酸酯和钠
• 中文别名: 7-溴-5-氯喹啉-醇
• 英文名称: 7-Bromo-5-chloroquinolin-ol
• 英文别名: 7-bromo-5-chloro-1H-quinolin-2-one
• CAS: 94275-80-6
• 化学式: C₉H₅BrClNO
• 分子量: 258.5
• InChiKey: AFLLVELQLSQJHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TREATMENTS FOR NEUROPATHY
  申请人：Corfas Gabriel

  公开号：US20090203735A1

  公开（公告）日：2009-08-13

  Small fiber neuropathy is treated or prevented by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat or prevent neuropathy in the subject. Glial cell-derived neurotrophic factor (GDNF) receptors are modulated with the subject active quinoline compounds, which may be formulated in topical lotions.
• Treatments for Neuropathy
  申请人：Corfas Gabriel

  公开号：US20110086878A1

  公开（公告）日：2011-04-14

  Small fiber neuropathy is treated or prevented by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat or prevent neuropathy in the subject. Glial cell-derived neurotrophic factor (GDNF) receptors are modulated with the subject active quinoline compounds, which may be formulated in topical lotions.
• COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY
  申请人：CHILDEREN'S MEDICAL CENTER CORPORATION

  公开号：US20160045487A1

  公开（公告）日：2016-02-18

  The invention features XIB4035 for the treatment of large fiber neuropathy, and combinations of XIB4035 and GDNF for the treatment of both large and small fiber neuropathies.
• US7863295B2
  申请人：——

  公开号：US7863295B2

  公开（公告）日：2011-01-04
• [EN] COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UNE NEUROPATHIE
  申请人：CHILDRENS MEDICAL CENTER

  公开号：WO2014160811A1

  公开（公告）日：2014-10-02

  The invention features XIB4035 for the treatment of large fiber neuropathy, and combinations of XIB4035and GDNF for the treatment of both large and small fiber neuropathies.