1-[(2,4-Dimethoxyphenyl)methyl]-5-phenyltetrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[(2,4-Dimethoxyphenyl)methyl]-5-phenyltetrazole
• 英文别名: 1-[(2,4-dimethoxyphenyl)methyl]-5-phenyltetrazole
• 化学式: C₁₆H₁₆N₄O₂
• 分子量: 296.329
• InChiKey: PVAOIAPQIOKVDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-bromobenzyl benzoate 、 1-[(2,4-Dimethoxyphenyl)methyl]-5-phenyltetrazole 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 三甲基乙酸钾 、 potassium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 6.0h， 以55%的产率得到{2'-[1-(2,4-dimethoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl benzoate
  参考文献：
  名称：

  2,4-Dimethoxybenzyl Group for the Protection of Tetrazole: An Efficient Synthesis of Olmesartan Medoxomil through C–H Arylation

  摘要：

  The 2,4-dimethoxybenzyl (DMB) group was found to be effective for protecting tetrazoles. The DMB group is inert to various conditions, including those for ruthenium-catalyzed C-H arylation, but is readily cleaved under mild conditions. The use of a DMB protecting group permitted a synthesis of highly functionalized olmesartan medoxomil in a few steps.

  DOI：

  10.1055/s-0034-1378848

文献信息

• 2,4-Dimethoxybenzyl Group for the Protection of Tetrazole: An Efficient Synthesis of Olmesartan Medoxomil through C–H Arylation
  作者：Masahiko Seki

  DOI：10.1055/s-0034-1378848

  日期：——

  The 2,4-dimethoxybenzyl (DMB) group was found to be effective for protecting tetrazoles. The DMB group is inert to various conditions, including those for ruthenium-catalyzed C-H arylation, but is readily cleaved under mild conditions. The use of a DMB protecting group permitted a synthesis of highly functionalized olmesartan medoxomil in a few steps.