1,2-二氯-9,10-蒽醌 | 1594-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 1,2-二氯-9,10-蒽醌
• 英文名称: 1,2-dichloro-anthraquinone
• 英文别名: 1,2-Dichlor-anthrachinon；dichloroanthraquinone；1,2-Dichloranthrachinon；1,2-Dichloroanthracene-9,10-dione
• CAS: 1594-46-3
• 化学式: C₁₄H₆Cl₂O₂
• 分子量: 277.106
• InChiKey: PLUFITIFLBGFPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2914700090

反应信息

• 作为反应物：
  描述：

  1,2-二氯-9,10-蒽醌 在 copper(I) oxide 、 ammonium hydroxide 、 硝酸铵 、 potassium chlorate 作用下， 生成 1,2-二氨基蒽醌
  参考文献：
  名称：

  1,2-和2,3-二氨基蒽醌的制备

  摘要：

  DOI：

  10.1021/ie50285a026
• 作为产物：
  描述：

  2-氯蒽醌 生成 1,2-二氯-9,10-蒽醌
  参考文献：
  名称：

  Schilling, Chemische Berichte, 1913, vol. 46, p. 1068

  摘要：

  DOI：

文献信息

• Process for the preparation of diamino-dihydroxy anthraquinone disperse
  申请人：Bayer Aktiengesellschaft

  公开号：US04029680A1

  公开（公告）日：1977-06-14

  The invention relates to the preparation of anthraquinone disperse dyestuffs from aqueous solutions containing anthraquinone-sulphonic acid mixtures, especially from appropriate waste waters by treating such solutions with chloric acid/hydrochloric acid or their salts or activated halogene, isolating the halogenoanthraquinones thereby obtained, subjecting them to dinitration and warming the dinitrohalogenoanthraquinones thus obtained with elementary sulphur in sulphuric acid optionally in the presence of boric acid. The reaction products are .beta.-halogenated diaminodihydroxyanthraquinones which are suitable for the dyeing of polyesters and polyamides in blue shades with good fastness properties.

  该发明涉及从含有蒽醌磺酸混合物的水溶液中制备蒽醌分散染料的方法，特别是通过用氯酸/盐酸或它们的盐或活性卤素处理这种溶液，从而从适当的废水中制备这些染料。随后，将得到的卤代蒽醌分离出来，经过二硝化处理，然后将得到的二硝基卤代蒽醌与硫酸中的元素硫加热，可选地在硼酸存在下。反应产物是适用于聚酯和聚酰胺染色的β-卤代二氨基二羟基蒽醌，具有良好的色牢度性能，呈现蓝色调。
• Anthracene derivatives as anti-cancer agents
  申请人：——

  公开号：US20030130272A1

  公开（公告）日：2003-07-10

  Use of compound of Formula (I): at least one of R 1 , R 2 , R 5 and R 6 is a group —AB and the others are independently selected from hydrogen, hydroxy, alkoxy or acyloxy, a group —AB a group -amino-(R 7 ) n X—Y wherein R 7 is a divalent organic radical and n is 0 or 1; R 3 and R 4 are independently oxo, hydroxy or hydrogen; the or each A is independently a spacer group of formula -amino-(R 7 ) n —X— which is bonded to the anthracene ring via the amino group nitrogen and to B via —X—, X is independently selected from O, NH and C(O); B is an amino acid residue or a peptide group or isostere thereof and Y is hydrogen or a capping group, or a physiologically acceptable derivative of such compound for the manufacture of a medicament for the treatment of cancers or microbial infections having cells exhibiting topoisomerase I activity characterised in that the group -amino-(R 7 ) n —X— incorporates an optionally substituted heterocyclic ring directly attached to the anthroquinone ring through an amino nitrogen in the heterocycclic ring, or an optionally substituted heterocyclic or carbocyclic ring that is spaced from the anthraquinone ring by no more than an amino nitrogen and up to four carbon atoms.

  使用化合物Formula (I)：R1、R2、R5和R6中至少一个是群组—AB，其余的可独立选择氢、羟基、烷氧基或酰氧基，一个群组—AB，一个群组-amino-(R7)nX—Y，其中R7是二价有机基团，n为0或1；R3和R4独立地为氧、羟基或氢；每个A独立地为配体基团，其公式为-amino-(R7)n—X—，通过氨基氮与蒽环键合，并通过—X—与B键合，X独立地选择自O、NH和C(O)；B为氨基酸残基或肽基团或其异构体，Y为氢或一个封端基团，或其生理可接受的衍生物，用于制造治疗癌症或微生物感染的药物，这些疾病的细胞具有拓扑异构酶I活性，其特点在于群组-amino-(R7)n—X—包含一个可选择取代的杂环直接通过杂环环中的氨基氮与蒽醌环键合，或通过不超过一个氨基氮和最多四个碳原子与蒽醌环相距的可选择取代的杂环或碳环。
• [EN] TRIPTYCENE DERIVATIVES FOR NUCLEIC ACID JUNCTION STABILIZATION<br/>[FR] DÉRIVÉS DE TRIPTYCÈNE POUR STABILISER DES JONCTIONS D'ACIDE NUCLÉIQUE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2017053982A1

  公开（公告）日：2017-03-30

  The present invention is directed to compositions and methods using triptycene derivatives (TCDs) for three way junctions (TWJs).

  本发明涉及使用三苯基衍生物（TCDs）用于三路交叉点（TWJs）的组合物和方法。
• Preparation of chloroanthraquinones from nitroanthraquinones
  申请人：Bayer Aktiengesellschaft

  公开号：US04054587A1

  公开（公告）日：1977-10-18

  The nitro group of an .alpha.-nitroanthraquinone is replaced by chlorine by reaction with an ionic chloride in a solvent in the presence of an acid or of a compound which eliminates an acid. The ionic chloride may be an alkali metal, alkaline earth metal, ammonium or quaternary ammonium chloride. A molten tertiary amine hydrochloride can function as the ionic chloride, the acid and the solvent. The process permits one or more nitro groups of a poly-.alpha.-nitroanthraquinone to be selectively replaced.

  一个α-硝基蒽醌的硝基基团在溶剂中与离子氯化物反应，在酸或消除酸的化合物的存在下，被氯取代。离子氯化物可以是碱金属、碱土金属、铵或季铵盐。熔融的三级胺盐酸可以作为离子氯化物、酸和溶剂。该过程允许选择性地取代多个α-硝基蒽醌的硝基基团。
• Methods for treating inflammatory conditions or inhibiting JNK
  申请人：——

  公开号：US20040072888A1

  公开（公告）日：2004-04-15

  This invention generally relates to methods for treating or preventing an inflammatory disease or disorder comprising administering to a patient in need thereof an effective amount of a Pyrazoloanthrone Derivative having the following structure: 1 or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are as defined herein.

  本发明通常涉及治疗或预防炎症性疾病或紊乱的方法，包括向需要治疗的患者施用以下结构的吡唑酮衍生物的有效量：1或其药学上可接受的盐，其中R1和R2如此处所定义。