抗坏血酸镁 | 15431-40-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 中文名称: 抗坏血酸镁
• 中文别名: L(+)-抗坏血酸镁盐；维生素C镁盐
• 英文名称: Magnesium ascorbate hydrate
• CAS: 15431-40-0
• 化学式: C6H8MgO6
• 分子量: 200.43
• InChiKey: SBCMUHSRBJVMOA-RXSVEWSESA-N

物化性质

• LogP：
  -2.653 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.79
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 安全说明：
  S22,S24/25

制备方法与用途

抗坏血酸镁是一种白色的粉末，极易溶解于水中，但不溶于乙醇、丙酮等有机溶剂。它在空气中容易吸湿。

文献信息

• Transdermal drug delivery device
  申请人：Polytronics, Ltd.

  公开号：EP0845281A2

  公开（公告）日：1998-06-03

  A first conductive sheet film (12) is disposed on a partial area of the skin-contact surface of an adhesive member (1). A conductive matrix (3) is disposed on the first conductive film, the conductive matrix being dispersed with drug to be permeated through skin. A second conductive film (41) is disposed on the conductive matrix, the second conductive film having a plurality of openings distributed on the surface of the conductive matrix and having a standard single electrode potential lower than that of the first conductive film. An insulating film (42) is disposed between the conductive matrix and the second conductive film to present an electric short path between the conductive matrix and the second conductive film. The insulating film has a plurality of openings distributed on the surface of the conductive matrix. A connection member (5,5') electrically interconnects the said first and second conductive films.

  在粘合剂部件 (1) 皮肤接触面的部分区域上放置第一导电片膜 (12)。导电矩阵 (3) 位于第一导电薄膜上，导电矩阵中分散有药物，可通过皮肤渗透。导电基质上设置有第二导电膜 (41)，第二导电膜在导电基质表面分布有多个开口，其标准单电极电位低于第一导电膜的标准单电极电位。绝缘膜 (42) 位于导电基体和第二导电膜之间，在导电基体和第二导电膜之间形成一条电短路。绝缘膜有多个开口，分布在导电基体的表面。连接部件（5,5'）将上述第一和第二导电膜电气互连。
• Serum-free mammalian cell culture medium, and uses thereof
  申请人：INVITROGEN CORPORATION

  公开号：EP1482031A1

  公开（公告）日：2004-12-01

  The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro, using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprisng an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

  本发明提供了一种支持体外培养，特别是悬浮培养哺乳动物细胞，尤其是上皮细胞和成纤维细胞的细胞培养基配方，以及使用这些培养基体外培养悬浮哺乳动物细胞的方法。培养基包括基础培养基和多阴离子或多阳离子化合物，最好是多磺酸盐或多硫酸盐化合物，更优选硫酸葡聚糖。本发明还提供了化学定义的、不含蛋白质的真核细胞培养基，其中包含铁螯合物和锌，能够支持悬浮培养中的生长（特别是哺乳动物细胞的高密度生长），提高培养细胞中重组蛋白的表达水平，和/或提高培养细胞中病毒的产量。
• HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1602354A1

  公开（公告）日：2005-12-07

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。
• Animal cell culture media comprising plant-derived nutrients
  申请人：Invitrogen Corporation

  公开号：EP1983044A2

  公开（公告）日：2008-10-22

  The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation of animal cells. The media comprise at least one nutrient of plant derivation, such as at least one plant peptide and/or at least one plant lipid and/or at least one plant fatty acid. The media may further optionally comprise an enzymatic digest or extract of yeast cells. The present invention also provides methods of cultivating animal cells in vitro using these cell culture media formulations. In addition, the media of the present invention can be used for growth of animal cells for virus production.

  本发明提供能够支持动物细胞体外培养的无血清细胞培养基配方。培养基中至少含有一种植物营养物质，如至少一种植物肽和/或至少一种植物脂质和/或至少一种植物脂肪酸。培养基还可进一步包括酵母细胞的酶解物或提取物。本发明还提供了使用这些细胞培养基配方体外培养动物细胞的方法。此外，本发明的培养基还可用于生产病毒的动物细胞的生长。
• Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium
  申请人：Life Technologies Corporation

  公开号：EP2218775A1

  公开（公告）日：2010-08-18

  The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro, using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

  本发明提供了一种支持体外培养，特别是悬浮培养哺乳动物细胞，尤其是上皮细胞和成纤维细胞的细胞培养基配方，以及使用这些培养基体外培养悬浮哺乳动物细胞的方法。培养基包括基础培养基和多阴离子或多阳离子化合物，最好是多磺酸盐或多硫酸盐化合物，更优选硫酸葡聚糖。本发明还提供了化学定义的、不含蛋白质的真核细胞培养基，该培养基由铁螯合物和锌组成，能够支持悬浮培养中的生长（特别是哺乳动物细胞的高密度生长），提高培养细胞中重组蛋白的表达水平，和/或增加培养细胞中的病毒产量。