2-Isopropyl-3-methoxycinnamic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-Isopropyl-3-methoxycinnamic acid
• 英文别名: (E)-3-(3-methoxy-2-propan-2-ylphenyl)prop-2-enoic acid
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.26
• InChiKey: QWXXXRFASGFHKU-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methods and compositions for treating metabolic disorders
  申请人：Mootha Vamsi Krishna

  公开号：US20090143279A1

  公开（公告）日：2009-06-04

  The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment metabolic diseases and neurodegenerative diseases. The methods are also useful to increase oxidative phosphorylation or to decrease reactive oxygen species (ROS) production in a subject in need thereof.
• COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING
  申请人：Bulawa Christine

  公开号：US20100305068A1

  公开（公告）日：2010-12-02

  Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for producing a protein and identifying compounds that rescue protein trafficking defects.
• SMALL MOLECULE MODULATORS OF PRONGF UPTAKE
  申请人：Hempstead Barbara L.

  公开号：US20110189310A1

  公开（公告）日：2011-08-04

  The present invention relates to a method of inhibiting cellular uptake of pro-nerve growth factor (proNGF) in a cell expressing neurotrophin p75 receptor in a mammal in need thereof. Such mammals include, for example, those suffering from neuropathological conditions. In another aspect, the invention relates to a method of promoting cellular uptake of proNGF in a cell expressing p75 NTR receptor in a mammal in need thereof. Such mammals include, for example, those suffering from conditions relating to human and other mammalian hair follicle cycling.
• [EN] METHODS AND COMPOSITIONS FOR TREATING METABOLIC DISORDERS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR TRAITER DES TROUBLES MÉTABOLIQUES
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2008156654A2

  公开（公告）日：2008-12-24

  [EN] The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment metabolic diseases and neurodegenerative diseases. The methods are also useful to increase oxidative phosphorylation or to decrease reactive oxygen species (ROS) production in a subject in need thereof.
  [FR] La présente invention porte sur des procédés de traitement de troubles caractérisés par une activité mitochondriale défectueuse. En particulier, les composés de la présente invention peuvent être utilisés dans le traitement de maladies métaboliques et de maladies neurodégénératives. Les procédés sont également utiles pour augmenter la phosphorylation oxydative ou pour diminuer la production d'espèce oxygène réactive (ROS) chez un sujet en ayant besoin.
• [EN] SMALL MOLECULE MODULATORS OF PRONGF UPTAKE<br/>[FR] MODULATEURS À PETITE MOLÉCULE D'UNE ABSORPTION DE PRONGF
  申请人：UNIV CORNELL

  公开号：WO2010042728A1

  公开（公告）日：2010-04-15

  The present invention relates to a method of inhibiting cellular uptake of pro-nerve growth factor (proNGF) in a cell expressing neurotrophin p75 receptor in a mammal in need thereof. Such mammals include, for example, those suffering from neuropathological conditions. In another aspect, the invention relates to a method of promoting cellular uptake of proNGF in a cell expressing p75NTR receptor in a mammal in need thereof. Such mammals include, for example, those suffering from conditions relating to human and other mammalian hair follicle cycling.