1,4-二乙基-2,5-哌嗪二酮 | 38927-89-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,4-二乙基-2,5-哌嗪二酮
• 英文名称: 1,4-diethylpiperazine-2,5-dione
• 英文别名: 1,4-diethyl-piperazine-2,5-dione；1,4-Diaethyl-piperazin-2,5-dion
• CAS: 38927-89-8
• 化学式: C₈H₁₄N₂O₂
• 分子量: 170.211
• InChiKey: IGXLIXJTSZCBCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  1,4-二乙基-2,5-哌嗪二酮 在 N-溴代丁二酰亚胺(NBS) 、 potassium triiodide 、 偶氮二异丁腈 、 碘 、 氢气 作用下， 以 氯仿 、 水 为溶剂， 生成 5,7-Diethyl-2,3-dithia-5,7-diaza-bicyclo[2.2.2]octane-6,8-dione
  参考文献：
  名称：

  Resolution and biological activities of optical isomers of 1,4-diethyl-3,6-epidithiopiperazine-2,5-dione

  摘要：

  Epipolythiopiperazine-2,5-diones (ETPs) are an important class of biologically active fungal metabolites. We have successfully synthesised and resolved racemic 1,4-diethyl-3,6-epidithiopiperazine-2,5-dione using chiral HPLC. The biological activities of the enantiomers were investigated to determine the correlation between biological activity and chirality at the bridgehead carbons. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10052-x
• 作为产物：
  描述：

  乙基N-乙基甘氨酸酯 生成 1,4-二乙基-2,5-哌嗪二酮
  参考文献：
  名称：

  �ber die Zersetzung von ?-Amino-N-carbons�ureanhydriden mit Pyridin und Pyridinderivaten. (Zur Frage der Bildung von h�hermolekularen Cyklopeptiden)

  摘要：

  DOI：

  10.1007/bf00902771

文献信息

• Phenyl-piperazine derivatives as modulators of muscarinic receptors
  申请人：Blanco Miguel Garcia-Guzman

  公开号：US20090239873A1

  公开（公告）日：2009-09-24

  The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

  本发明涉及肌动蛋白受体的调节剂。本发明还提供包含这种调节剂的组合物，并提供了使用这些组合物治疗肌动蛋白受体介导疾病的方法。
• Photosensitive compositions and applications thereof
  申请人：PROMERUS, LLC

  公开号：US11537045B2

  公开（公告）日：2022-12-27

  The present invention relates to photosensitive compositions containing polynorbornene (PNB) polymers and certain additives that are useful for forming microelectronic and/or optoelectronic devices and assemblies thereof, and more specifically to compositions encompassing PNBs and certain multifunctional crosslinking agents, and two or more phenolic compounds which are resistant to thermo-oxidative chain degradation and exhibit improved mechanical properties.

  本发明涉及含有聚降冰片烯（PNB）聚合物和某些添加剂的光敏组合物，这些组合物可用于形成微电子和/或光电器件及其组件，更具体地说，本发明涉及包含 PNB 和某些多功能交联剂以及两种或两种以上酚类化合物的组合物，这些组合物可抗热氧化链降解，并具有更好的机械性能。
• The compound 1,4-diisopropyl-2,5-diketopiperazine
  申请人：Monsanto Company

  公开号：EP0216744B1

  公开（公告）日：1991-08-14
• Enantioselective organocatalytic α-sulfenylation of substituted diketopiperazines
  作者：Nathan W. Polaske、Ramin Dubey、Gary S. Nichol、Bogdan Olenyuk

  DOI：10.1016/j.tetasy.2009.10.037

  日期：2009.12

  The asymmetric organocatalytic alpha-sulfenylation of substituted piperazine-2,5-diones is reported, with cinchona alkaloids as chiral Lewis bases and electrophilic sulfur transfer reagents. Catalyst loadings, the type of sulfur transfer reagent, temperature and solvent were investigated in order to optimize the reaction conditions. The effects of ring substitution and the type of catalyst on the yield and enantioselectivity of the reaction are reported. (C) 2009 Elsevier Ltd. All rights reserved.
• Efficient organocatalytic α-sulfenylation of substituted piperazine-2,5-diones
  作者：Ramin Dubey、Nathan W. Polaske、Gary S. Nichol、Bogdan Olenyuk

  DOI：10.1016/j.tetlet.2009.05.031

  日期：2009.7

  Organocatalytic alpha-sulfenylation of substituted piperazine-2,5-diones is reported through the use of cinchona alkaloids as Lewis bases and electrophilic sulfur transfer reagents. 1-Phenylsulfanyl[1,2,4]triazole, a novel Sulfur transfer reagent, gave excellent product yields with a number of substituted piperazine-2,5-diones under mild conditions. Catalyst loading, stoichiometry Of Sulfur electrophile, temperature, and solvent were optimized to achieve high product yields. (C) 2009 Elsevier Ltd. All rights reserved.