1,4-二氯-1,4-二甲氧基丁烷 | 86428-38-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,4-二氯-1,4-二甲氧基丁烷
• 英文名称: 1,4-dichloro-1,4-dimethoxybutane
• CAS: 86428-38-8
• 化学式: C₆H₁₂Cl₂O₂
• 分子量: 187.066
• InChiKey: JLGRYZIMCDCFIF-UHFFFAOYSA-N

物化性质

• 沸点：
  224.2±40.0 °C(Predicted)
• 密度：
  1.141±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-二氯-1,4-二甲氧基丁烷 、 6-氨基-3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸 在 Amberlyst A-21 resin 作用下， 生成 6-(1-pyrrolyl)penicillanic acid
  参考文献：
  名称：

  1,4-Dichloro-1,4-dimethoxybutane as a mild reagent for the conversion of primary amines to pyrroles. Synthesis of a pyrrole compound from tobacco

  摘要：

  DOI：

  10.1021/jo00166a025
• 作为产物：
  描述：

  2,5-二甲氧基四氢呋喃 在 三甲基氯硅烷 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以86%的产率得到1,4-二氯-1,4-二甲氧基丁烷
  参考文献：
  名称：

  1,4-Dichloro-1,4-dimethoxybutane as a mild reagent for the conversion of primary amines to pyrroles. Synthesis of a pyrrole compound from tobacco

  摘要：

  DOI：

  10.1021/jo00166a025

文献信息

• Amidocarboxylic acid derivatives
  申请人：Sankyo Company, Limited

  公开号：US06528525B1

  公开（公告）日：2003-03-04

  Amidocarboxylic acid derivatives of the formula: wherein R1 represents a hydrogen atom, etc.; R2 represents an alkylene group; R3 represents a hydrogen atom, etc.; R4 represents a hydrogen atom, etc.; X represents a substituted or unsubstituted aryl group, etc.,; Y represents an oxygen atom, etc.; Z represents an alkylene group, etc.; and W represents an alkyl group, etc.; and pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof are useful as the active ingredient of pharmaceutical compositions. They may be used to treat specified diseases, including diabetes mellitus, hyperlipemia, arteriosclerosis, hypertension, etc.

  公式为：其中R1代表氢原子，等等；R2代表烷基团；R3代表氢原子，等等；R4代表氢原子，等等；X代表取代或未取代的芳基团，等等；Y代表氧原子，等等；Z代表烷基团，等等；W代表烷基团，等等；以及其药理学上可接受的盐和药理学上可接受的酯作为药物组合物的活性成分是有用的。它们可用于治疗特定疾病，包括糖尿病、高脂血症、动脉硬化、高血压等。
• Indoles
  申请人：Eisai Co., Ltd.

  公开号：US20020019531A1

  公开（公告）日：2002-02-14

  A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: 1 wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R 1 , R 2 , R 3 , R 4 , and R 5 each represent a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3. The compounds have serotonin antagonism. They are therefore clinically useful as medicaments, in particular, for treating, ameliorating, and preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.

  一种由以下公式表示的1,4-取代的环胺衍生物或其药理学上可接受的盐： 其中A、B、C、D、T、Y和Z分别表示亚甲基或氮键合物；R1、R2、R3、R4和R5分别表示取代基；n表示0或1至3的整数；m表示0或1至6的整数；p表示1至3的整数。这些化合物具有5-羟色胺拮抗作用。因此，在临床上作为药物特别有用，用于治疗、改善和预防痉挛性瘫痪。它们还可用作中枢肌肉松弛剂，改善肌张力过高。
• Sleep inducing compounds and methods relating thereto
  申请人：Beaton Graham

  公开号：US20060014797A1

  公开（公告）日：2006-01-19

  Compounds having the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R 1 , R 2 , R 3a , R 3b , L 1 , L 2 and n are as defined herein. Such compounds generally function as H 1 receptor ligands, and thus have utility as sleep inducing agents. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

  具有以下结构（I）的化合物，包括立体异构体、前药、以及其药用可接受的盐、酯和溶剂合物，其中R1、R2、R3a、R3b、L1、L2和n如本文所定义。这些化合物通常作为H1受体配体发挥作用，因此具有作为催眠药的用途。还披露了含有结构（I）化合物的药物组合物，以及与其使用相关的方法。
• Conversion of primary amides into active acylating agents via acylpyrroles.
  作者：S.D. Lee、Michael A. Brook、T.H. Chan

  DOI：10.1016/s0040-4039(00)81712-8

  日期：——

  Several primary amides were converted to N-acylpyrroles on reaction with 1,4-dichloro-1,4-dimethoxybutane (1) and Amberlyst A-21 resin. The acylpyrroles act as active acylating agents.

  与1,4-二氯-1,4-二甲氧基丁烷（1）和Amberlyst A-21树脂反应后，几种伯酰胺转化为N-酰基吡咯。酰基吡咯用作活性酰化剂。
• N-heterocyclyl substituted thienyloxy-pyrimidines used as herbicides
  申请人：——

  公开号：US20040198758A1

  公开（公告）日：2004-10-07

  N-heterocyclyl-substituted thienyloxypyrimidines of the formula I 1 where: W, X, Y, Z independently of one another are N or CR 3 , where at least one of the variables is CR 3 ; R 1 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy or haloalkoxy; R 2 is hydrogen, halogen, cyano, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, alkoxy, alkenyloxy, alkynyloxy, haloalkoxy, alkoxyalkyl, alkylamino, dialkylamino, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, COOR 7 or CONR 8 R 9 ; R 3 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio or haloalkylthio, alkylsulfonyl or COOR 7 R 4 , R 5 , R 6 are hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfonyl or haloalkylsulfonyl; R 7 is hydrogen, alkyl, alkenyl, alkynyl or haloalkyl; R 8 is hydrogen, alkyl, alkenyl, alkynyl or alkoxy; R 9 is hydrogen, alkyl, alkenyl or alkynyl; and their agriculturally useful salts; processes and intermediates for their preparation; and the use of these compounds or of compositions comprising these compounds for controlling undesirable plants are described.

  化合物I1的N-杂环取代噻吩氧嘧啶，化学式如下： 其中： W、X、Y、Z独立地为N或CR3，至少一个变量为CR3； R1为氢、卤素、氰基、烷基、卤代烷基、烷氧基或卤代烷氧基； R2为氢、卤素、氰基、烷基、烯基、炔基、卤代烷基、卤代烯基、卤代炔基、烷氧基、烯氧基、炔氧基、卤代烷氧基、烷氧基烷基、烷基氨基、二烷基氨基、烷基硫基、卤代烷硫基、烷基亚磺酰基、卤代烷亚磺酰基、烷基磺酰基、卤代烷磺酰基、COOR7或CONR8R9； R3为氢、卤素、氰基、硝基、烷基、卤代烷基、烷氧基、卤代烷氧基、烷硫基或卤代烷硫基、烷基磺酰基或COOR7R4； R4、R5、R6为氢、卤素、氰基、烷基、卤代烷基、烷氧基、卤代烷氧基、烷硫基、卤代烷硫基、烷基磺酰基或卤代烷磺酰基； R7为氢、烷基、烯基、炔基或卤代烷基； R8为氢、烷基、烯基、炔基或烷氧基； R9为氢、烷基、烯基或炔基； 以及它们的农业有用盐；描述了它们的制备过程和中间体；以及使用这些化合物或包含这些化合物的组合物来控制不良植物。