1,4-二辛氧基-1,4-二氧代丁烷-2-磺酸 | 2373-23-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 1,4-二辛氧基-1,4-二氧代丁烷-2-磺酸
• 中文别名: 硫酰胺,[5-(二甲氨基)-2-羟基苯基]-(9CI)
• 英文名称: dioctyl sulphosuccinate
• 英文别名: propranolol-dioctyl sulfosuccinate；dioctyl sulfosuccinate；octyl Sulphosuccinate；1,2-bis-octyloxycarbonyl-ethanesulfonic acid；1,2-Bis-octyloxycarbonyl-aethansulfonsaeure；Sulfobernsteinsaeure-dioctylester；Succinic acid, sulfo-, 1,4-dioctyl ester；1,4-dioctoxy-1,4-dioxobutane-2-sulfonic acid
• CAS: 2373-23-1
• 化学式: C₂₀H₃₈O₇S
• 分子量: 422.584
• InChiKey: OXLXSOPFNVKUMU-UHFFFAOYSA-N

物化性质

• 密度：
  1.098±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

毒理性

• 相互作用

杜索酯可增加同时给药的其他药物的肠道吸收，并可能增加它们的毒性。

Docusates increase the intestinal absorption of other drugs administered concurrently and may increase their toxicity. /Docusates/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

吞咽会导致腹泻和肠道胀气。

Ingestion causes diarrhea and intestinal bloating.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

双酮类化合物（Docusates）耐受性良好。偶尔报告有痉挛性疼痛，并且液体制剂有时会引起恶心。

The docusates are well tolerated. Cramping pains have been reported occasionally, and the liquid preparations sometimes cause nausea. /Docusates/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

特别值得关注的是，观察到二辛基硫酸钠被吸收，在胆汁中以显著浓度出现，并且对组织培养中的肝细胞具有细胞毒性作用。

Of particular concern are the observations that docusate sodium is absorbed, appears in the bile in significant conc, and has cytotoxic effects on liver cells in tissue culture.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

给予毒性剂量的动物中仅报告出现腹泻和肠道膨胀。

Water and salt accumulated in ligated colonic segments of DSS-treated rats whereas net absorption of isotonic saline solution occurred in control rats. When segments of rodent ileum, jejunum and colon were perfused with 0.5 mM DSS, mucosal cells were flattened and their brush borders disappeared. ... Only diarrhea and intestinal bloating are reported in animals given toxic doses.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

... 硫酸二钠被吸收，在胆汁中以显著浓度出现 ... .

... Docusate sodium is absorbed, appears in the bile in significant concn ... .

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2914509090

反应信息

• 作为产物：
  描述：

  sodium dioctyl sulfosuccinate 在 盐酸 作用下， 以 异丙醇 为溶剂， 反应 3.0h， 以96.5%的产率得到1,4-二辛氧基-1,4-二氧代丁烷-2-磺酸
  参考文献：
  名称：

  Gol'din, G. S.; Averbakh, K. O.; Nekrasova, L. A., Journal of applied chemistry of the USSR, 1992, vol. 65, # 9.2, p. 1663 - 1668

  摘要：

  DOI：
• 作为试剂：
  描述：

  邻甲苯胺 在 sodium hydroxide 、 1,4-二辛氧基-1,4-二氧代丁烷-2-磺酸 、 硫酸 、 水 、 硝酸 、 氯苯 作用下， 生成 4-硝基-2-甲苯胺
  参考文献：
  名称：

  Preparation of acyl-nitroarylides

  摘要：

  公开号：

  US02459002A1

文献信息

• N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES
  申请人：BAYER CROPSCIENCE AG

  公开号：US20140315898A1

  公开（公告）日：2014-10-23

  The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I) in which X 1 , X 2 , X 3 , X 4 , R 1 , R 2 , R 3 , n have the meanings given in the description—to their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation

  本发明涉及公式（I）中的新型N-芳酰胺取代三氟乙基硫醚衍生物，其中X1、X2、X3、X4、R1、R2、R3、n的含义如描述所示—它们作为杀螨剂和杀虫剂用于控制动物害虫，并涉及其制备的过程和中间体。
• FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES
  申请人：Bayer Aktiengesellschaft

  公开号：US20200383334A1

  公开（公告）日：2020-12-10

  The invention relates to novel compounds of the formula (I) in which Aa, Ab, Ac, Ad, Q, R 1 and n have the definitions given above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.

  这项发明涉及公式（I）的新化合物， 其中Aa、Ab、Ac、Ad、Q、R1和n具有上述给定的定义， 以及它们作为杀螨剂和/或杀虫剂用于控制动物害虫的用途，以及用于它们制备的工艺和中间体。
• SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS
  申请人：Bayer Aktiengesellschaft

  公开号：US20190269134A1

  公开（公告）日：2019-09-05

  The present invention relates to the use of a compound of the general formula (I) in which M and D have the meanings given in the description for controlling animal pests, in particular nematodes.

  本发明涉及使用一种具有一般式(I)的化合物，其中M和D具有描述中给出的含义，用于控制动物害虫，特别是线虫。
• Tetrakisazo Compound, Coloring Matter for Recording, Ink Composition and Colored Article
  申请人：Ohno Hiroaki

  公开号：US20070227388A1

  公开（公告）日：2007-10-04

  The present invention relates to black coloring matter, and relates to a compound represented by the following formula (1): (wherein A and D independently represent an optionally substituted phenyl group or naphthyl group, respectively, and m and n represent 1 or 2, respectively), and the coloring matter for recording and an ink comprising the same. Said compound exhibits high solubility in a medium containing water as a main component, is stable even when an aqueous dye solution or an ink having a high concentration is prepared therefrom and is stored for a long period of time, has low color rendering property, exhibits colorless and neutral black, provides a printed image having high density and also provides a black recorded image being excellent in moisture fastness, light fastness and an ozone gas fastness, and further can be synthesized easily and can be produced at a low cost.

  本发明涉及黑色着色剂，涉及以下式（1）表示的化合物： （其中A和D分别独立地代表一个可选地取代的苯基或萘基，m和n分别代表1或2），以及用于记录的着色剂和包含该着色剂的墨水。所述化合物在水作为主要成分的介质中表现出高溶解性，即使从其中制备了高浓度的水基染料溶液或墨水并长时间储存，也非常稳定，具有低显色性，呈现出无色和中性黑色，提供高密度的印刷图像，并且提供具有优异的耐湿性、耐光性和臭氧气体稳定性的黑色记录图像，并且可以容易地合成，可以低成本生产。
• [EN] PHENOXYETHANAMINE DERIVATIVES FOR CONTROLLING PESTS<br/>[FR] DÉRIVÉS DE PHÉNOXYÉTHANAMINE POUR LUTTER CONTRE DES ORGANISMES NUISIBLES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2018202525A1

  公开（公告）日：2018-11-08

  The invention is in the technical field of insect control and relates to novel phenoxyethanamine derivatives, their production and use for controlling pests and in particular insecticide-resistant pests such as mosquitoes and cockroaches.

  这项发明属于昆虫控制技术领域，涉及新型苯氧乙胺衍生物，其生产和用于控制害虫，特别是对抗蚊子和蟑螂等抗药性害虫的用途。