1-(1-甲氧基乙氧基)癸烷 | 1146218-80-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(1-甲氧基乙氧基)癸烷
• 英文名称: 1-(1-Methoxyethoxy)decane
• 英文别名: 1-(1-methoxyethoxy)decane
• CAS: 1146218-80-5
• 化学式: C₁₃H₂₈O₂
• 分子量: 216.364
• InChiKey: OEXCQOZSEAUSFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1-甲氧基乙氧基)癸烷 在 2,4,6-三甲基吡啶 、 三乙基硅基三氟甲磺酸酯 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以96%的产率得到癸醇
  参考文献：
  名称：

  Mild and Efficient Deprotection of Acetal-Type Protecting Groups of Hydroxyl Functions by Triethylsilyl Triflate — 2,4,6-Collidine Combination

  摘要：

  Deprotection of acetal-type protecting groups of hydroxyl functions has been studied in detail. The treatment of alcohol derivatives protected by acetal-type protecting groups with TESOTf-2,4,6-collidine followed by H(2)O-treatment produces the corresponding hydroxyl compounds in good yields. The characteristic features of the method are very mild and chemoselective, and acid-labile functional groups can tolerate these conditions.

  DOI：

  10.3987/com-08-s(f)88
• 作为产物：
  描述：

  二甲氧基乙烷 、 癸醇 在 2,4,6-三甲基吡啶 、 三乙基硅基三氟甲磺酸酯 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以25%的产率得到1-(1-甲氧基乙氧基)癸烷
  参考文献：
  名称：

  Mild and Efficient Deprotection of Acetal-Type Protecting Groups of Hydroxyl Functions by Triethylsilyl Triflate — 2,4,6-Collidine Combination

  摘要：

  Deprotection of acetal-type protecting groups of hydroxyl functions has been studied in detail. The treatment of alcohol derivatives protected by acetal-type protecting groups with TESOTf-2,4,6-collidine followed by H(2)O-treatment produces the corresponding hydroxyl compounds in good yields. The characteristic features of the method are very mild and chemoselective, and acid-labile functional groups can tolerate these conditions.

  DOI：

  10.3987/com-08-s(f)88

文献信息

• Mild and Efficient Deprotection of Acetal-Type Protecting Groups of Hydroxyl Functions by Triethylsilyl Triflate — 2,4,6-Collidine Combination
  作者：Hiromichi Fujioka、Yasuyuki Kita、Ozora Kubo、Kazuhisa Okamoto、Kento Senami、Takashi Okitsu、Yoshinari Sawama

  DOI：10.3987/com-08-s(f)88

  日期：——

  Deprotection of acetal-type protecting groups of hydroxyl functions has been studied in detail. The treatment of alcohol derivatives protected by acetal-type protecting groups with TESOTf-2,4,6-collidine followed by H(2)O-treatment produces the corresponding hydroxyl compounds in good yields. The characteristic features of the method are very mild and chemoselective, and acid-labile functional groups can tolerate these conditions.