普罗硝唑 | 76448-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 普罗硝唑
• 中文别名: 丙烯酯哒唑
• 英文名称: Propenidazole
• 英文别名: ethyl (2E)-2-[(1-methyl-5-nitroimidazol-2-yl)methylidene]-3-oxobutanoate
• CAS: 76448-31-2
• 化学式: C11H13N3O5
• 分子量: 267.24
• InChiKey: GCHKUUOPYMFGEY-VMPITWQZSA-N

物化性质

• 沸点：
  437.6±55.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• COMPOUNDS FOR THE INHIBITION OF INDOLEAMINE-2,3-DIOXYGENASE
  申请人：Merck Patent GmbH

  公开号：US20160075711A1

  公开（公告）日：2016-03-17

  The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of IDO, and for the treatment of IDO-related disorders.

  本发明涉及化合物及其药学上可接受的组合物，用作IDO拮抗剂，用于治疗与IDO相关的疾病。
• [EN] COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE<br/>[FR] COMPOSÉS UTILES COMME INHIBITEURS DE L'INDOLÉAMINE 2,3-DIOXYGÉNASE
  申请人：VERTEX PHARMA

  公开号：WO2014081689A1

  公开（公告）日：2014-05-30

  The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications.. The compounds of this invention have formula I-A; wherein the variables are as defined herein.

  本发明涉及作为吲哚胺2,3-二氧化酶（IDO）抑制剂的化合物。该发明还涉及包括本发明的化合物的药学可接受的组合物；使用本发明的化合物治疗各种疾病、紊乱和症状的方法；制备本发明的化合物的方法；用于制备本发明的化合物的中间体；以及在体外应用中使用这些化合物的方法。本发明的化合物具有I-A式的结构；其中变量如本文所定义。
• GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
  申请人：Cai Jianfeng

  公开号：US20150274782A1

  公开（公告）日：2015-10-01

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一种新型类别的抗微生物药物，称为γ-AA肽。当前发明提供了各种类别的γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂质化γ-AA肽。本发明的γ-AA肽被设计为具有抗微生物活性，同时稳定且无毒。γ-AA肽似乎也不会导致被治疗微生物体内微生物产生抗药性。因此，所披露的γ-AA肽可用于治疗与病原微生物相关的各种医疗状况。
• [EN] FUSED IMIDAZOLE DERIVATIVES AS IDO/TDO INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZOLE FUSIONNÉS UTILISÉS COMME INHIBITEURS D'IDO/TDO
  申请人：SCIFLUOR LIFE SCIENCES INC

  公开号：WO2017075341A1

  公开（公告）日：2017-05-04

  The present application relates to compounds and methods for the modulation (e.g., inhibition) of the enzyme indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase (IDO/TDO), and methods of treating diseases and disorders in which IDO/TDO plays a role. The present application provides compounds of Formula (I) or (II):

  本申请涉及化合物和调节酶吲哚胺2,3-二氧化酶和/或色氨酸2,3-二氧化酶（IDO/TDO）的方法（例如，抑制），以及治疗IDO/TDO在其中发挥作用的疾病和紊乱的方法。本申请提供Formula (I)或(II)的化合物：
• Inhibitors of fungal invasion
  申请人：——

  公开号：US20040106663A1

  公开（公告）日：2004-06-03

  This invention relates to isoxazole-based inhibitors of fungal invasion.

  这项发明涉及以异氧唑为基础的真菌入侵抑制剂。