1-(2,5,6-三甲基-3-吡啶基)乙酮 | 95652-44-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(2,5,6-三甲基-3-吡啶基)乙酮
• 英文名称: acetyl-3 trimethyl-2,5,6 pyridine
• 英文别名: Ethanone, 1-(2,5,6-trimethyl-3-pyridinyl)-；1-(2,5,6-trimethylpyridin-3-yl)ethanone
• CAS: 95652-44-1
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: KDJDFRUIWWWRNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氯代仲丁烷 、 乙酰氯 在 三氯化铝 、 氨 作用下， 生成 2,3,6-三甲基吡啶 、 1-(2,5,6-三甲基-3-吡啶基)乙酮
  参考文献：
  名称：

  Erre, Claude H.; Fouillade, Brigitte; Roussel, Christian, Bulletin de la Societe Chimique de France, 1984, vol. 2, # 7-8, p. 271 - 274

  摘要：

  DOI：

文献信息

• ERRE, C. H.;FOUILLADE, B.;ROUSSEL, CH., BULL. SOC. CHIM. FR., 1984, N 7-8, 271-274
  作者：ERRE, C. H.、FOUILLADE, B.、ROUSSEL, CH.

  DOI：——

  日期：——
• US9887371B2
  申请人：——

  公开号：US9887371B2

  公开（公告）日：2018-02-06
• [EN] 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR<br/>[FR] MODULATEURS ALLOSTÉRIQUES 6,7-DIHYDRO-5H-PYRROLO[3,4-B] PYRIDINE-5-ONE DU RÉCEPTEUR DE L'ACÉTYLCHOLINE MUSCARINIQUE M4
  申请人：MERCK SHARP & DOHME

  公开号：WO2017112719A1

  公开（公告）日：2017-06-29

  The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved. Formula (I).
• Erre, Claude H.; Fouillade, Brigitte; Roussel, Christian, Bulletin de la Societe Chimique de France, 1984, vol. 2, # 7-8, p. 271 - 274
  作者：Erre, Claude H.、Fouillade, Brigitte、Roussel, Christian

  DOI：——

  日期：——