1-(2,6-二羟基苯基)丁烷-1-酮 | 10121-26-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(2,6-二羟基苯基)丁烷-1-酮
• 英文名称: 1-(2,6-dihydroxyphenyl)butan-1-one
• 英文别名: 2,6-Dihydroxy-butyrophenon
• CAS: 10121-26-3
• 化学式: C₁₀H₁₂O₃
• mdl: MFCD00564165
• 分子量: 180.203
• InChiKey: GMFURTWBEPILKH-UHFFFAOYSA-N

物化性质

• 熔点：
  120 °C(Solv: water (7732-18-5))
• 沸点：
  292.0±20.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2,6-二羟基苯基)丁烷-1-酮 在 sodium acetate 作用下， 生成 3-ethyl-5-benzoyloxy-2-methyl-chromen-4-one
  参考文献：
  名称：

  Limaye; Shenolikar; Talwalkar, Rasayanam, 1941, vol. 1, p. 217,218

  摘要：

  DOI：
• 作为产物：
  描述：

  8-butyryl-7-hydroxy-4-methyl-coumarin 在 sodium hydroxide 作用下， 生成 1-(2,6-二羟基苯基)丁烷-1-酮
  参考文献：
  名称：

  Limaye; Talwalkar, Rasayanam, 1938, vol. 1, p. 141,143

  摘要：

  DOI：

文献信息

• グンバイ由来ポリケチドまたはその合成類縁体による、薬剤耐性黄色ブドウ球菌またはバンコマイシン耐性腸球菌用の抗菌剤並びに抗真菌剤
  申请人：学校法人永守学園

  公开号：JP2020152704A

  公开（公告）日：2020-09-24

  【課題】メチシリン耐性黄色ブドウ球菌やバンコマイシン耐性腸球菌に対する高い活性や、抗真菌活性を有する、天然物由来物又はその合成類縁体による抗菌剤・抗真菌剤及び抗菌・抗真菌製品の提供。【解決手段】下式で表される、2,6-DH8又はそのホモログを有効成分として含有する、メチシリン耐性黄色ブドウ球菌やバンコマイシン耐性腸球菌に対する抗菌剤、並びに抗真菌剤、及び、抗菌・抗真菌繊維製品。【選択図】なし

  【问题】提供天然物或其合成类似物所制备的抗菌剂、抗真菌剂和抗菌、抗真菌制品，具有对甲氧西林耐药的金黄色葡萄球菌和对万古霉素耐药的肠球菌有高活性和抗真菌活性。 【解决方案】提供含有2,6-DH8或其同源物作为有效成分的抗菌剂和抗真菌剂，以及抗菌和抗真菌纤维制品，用于对甲氧西林耐药的金黄色葡萄球菌和对万古霉素耐药的肠球菌的治疗。 【选择图】无
• Matrix metalloprotease (MMP) inhibitors and their application in cosmetic and pharmaceutical composition
  申请人：Gupta K. Shyam

  公开号：US20060074108A1

  公开（公告）日：2006-04-06

  This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease (also known as Matrix Metalloproteinase, MMP), to cosmetic and pharmaceutical compositions containing them, and to their use in the prevention and/or treatment of ailments associated with MMP, including inflammation, wound healing, skin aging, skin tone discoloration, body odor, oral cavity odor, rosacea, acne, and hair growth modulation.

  本发明涉及基质金属蛋白酶（又称基质金属蛋白酶，MMP）选择性抑制剂的化合物、含有这些化合物的化妆品和药物组合物，以及它们在预防和/或治疗与 MMP 有关的疾病中的用途，包括炎症、伤口愈合、皮肤老化、肤色变色、体味、口腔异味、酒渣鼻、痤疮和毛发生长调节。
• Threshold Dependence of Mortality Effects for Fine and Coarse Particles in Phoenix, Arizona
  作者：Richard L. Smith、Dan Spitzner、Yuntae Kim、Montserrat Fuentes

  DOI：10.1080/10473289.2000.10464172

  日期：2000.8

  Daily data for fine (<2.5 mu m) and coarse (2.5-10 mu m) particles are available for 1995-1997 from the U.S. Environmental Protection Agency (EPA) research monitor in Phoenix, AZ. Mortality effects on the 65 and over population were studied for both the city of Phoenix and for a region of about 50 mi around Phoenix. Coarse particles in Phoenix are believed to be natural in origin and spatially homogeneous, whereas fine particles are primarily vehicular in origin and concentrated in the city itself. For this reason, it is natural to focus on city mortality data when considering fine particles, and on region mortality data when considering coarse particles, and most of the results reported here correspond to those assignments.After allowing for seasonality and long-term trend through a nonlinear (B-spline) trend curve, and also for meteorological effects based on temperature and specific humidity, a regression of mortality was performed on PM using several different measures for PM. Based on a linear PM effect, we found a statistically significant coefficient for coarse particles, but not for fine particles, contrary to what is widely believed about the effects of coarse and fine particles. An analysis of nonlinear pollution-mortality relationships, however, suggests that the true picture is more complicated than that. For coarse particles, the evidence for any nonlinear or threshold-based effect is slight. For fine particles, we found evidence of a threshold, most likely with values in the range of 20-25 mu g/m(3). We also found some evidence of interactions of the PM effects with season and year.The main effect here is an apparent seasonal interaction in the coarse PM effect. An attempt was made to explain this in terms of seasonal variation in the chemical composition of PM, but this led to another counterintuitive result: the PM effect is highest in spring and summer, when the anthropogenic concentration of coarse PM is lowest as determined by a principal components analysis. There was no evidence of confounding between the fine and coarse PM effects. Although these results are based on one city and should be considered tentative until replicated in other studies, they suggest that the prevailing focus on fine rather than coarse particles may be an oversimplification. The study also shows that consideration of nonlinear effects can lead to real changes of interpretation and raises the possibility of seasonal effects associated with the chemical composition of PM.
• Naik et al., Proceedings - Indian Academy of Sciences, Section A, 1953, vol. 37, p. 765,768
  作者：Naik et al.

  DOI：——

  日期：——
• Schamschurin; Archangelskaja, Nr. 25 Chimija Nr. 1<1941>9, 14
  作者：Schamschurin、Archangelskaja

  DOI：——

  日期：——

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