1-(3,3,3-三氟丙-1-炔基)环戊烷-1-醇 | 151340-87-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(3,3,3-三氟丙-1-炔基)环戊烷-1-醇
• 英文名称: 1-(3,3,3-trifluoro-1-propynyl)-1-cyclopentanol
• 英文别名: 1-(3,3,3-Trifluoroprop-1-ynyl)cyclopentan-1-ol
• CAS: 151340-87-3
• 化学式: C₈H₉F₃O
• 分子量: 178.154
• InChiKey: NZYHTZLVYAXZKF-UHFFFAOYSA-N

物化性质

• 沸点：
  172.6±40.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(3,3,3-三氟丙-1-炔基)环戊烷-1-醇 在 溴 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 1-((E)-1,2-Dibromo-3,3,3-trifluoro-propenyl)-cyclopentanol
  参考文献：
  名称：

  Bobrovnikov, M. N., Russian Journal of Organic Chemistry, 1994, vol. 30, # 12, p. 1850 - 1856

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溴 作用下， 以 二氯甲烷 为溶剂， 生成 1-(3,3,3-三氟丙-1-炔基)环戊烷-1-醇
  参考文献：
  名称：

  Bobrovnikov, M. N., Russian Journal of Organic Chemistry, 1994, vol. 30, # 12, p. 1850 - 1856

  摘要：

  DOI：

文献信息

• The preparation and cycloaddition reaction of 1-sulfonyl-1-trifluoromethyl allenes
  作者：Jun-Li Li、Xian-Jin Yang、Min Jiang、Jin-Tao Liu

  DOI：10.1016/j.tetlet.2017.07.050

  日期：2017.8

  A series of 1-sulfonyl-1-trifluoromethyl allenes were prepared for the first time from commercial available 2-bromo-3,3,3-trifluoropropene. Cycloaddition reaction of these trifluoromethylated allenes with nitrones occured readily under mild conditions, giving the corresponding trifluoromethylated isoxazolidines in high yields.

  由市售的2-溴-3,3,3-三氟丙烯首次制备了一系列的1-磺酰基-1-三氟甲基丙二烯。这些三氟甲基化的烯与亚硝基的环加成反应在温和条件下容易发生，从而以高收率得到相应的三氟甲基化的异恶唑烷。
• Palladium-catalyzed cyclocarbonylation of trifluoromethyl propargylic alcohols producing 3-trifluoromethyl-2(5H)-furanones (γ-lactones)
  作者：Zhong-Xing Jiang、Feng-Ling Qing

  DOI：10.1016/s0040-4039(01)02006-8

  日期：2001.12

  The reaction of trifluoromethyl propargylic alcohols 1, CO and H-2 in the presence of catalytic Pd(OAc)(2) and PPh3 afforded 3-tifluoroinethyl-2(5H)-furanones 2 in high yields. (C) 2001 Published by Elsevier Science Ltd.
• Sodium carbonate as carbon dioxide source for the synthesis of cyclic carbonates containing the trifluoromethyl group
  作者：Zhong-Xiang Jiang、Feng-Ling Qing

  DOI：10.1016/s0022-1139(03)00136-2

  日期：2003.9

  Trifluoromethylated cyclic carbonates were prepared through the palladium-promoted reaction of tertiary trifluoromethylated propargylic alcohols and sodium carbonate. (C) 2003 Elsevier Science B.V. All rights reserved.
• Bobrovnikov, M. N.; Turbanova, E. S.; Shishenin, S. A., Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 10.1, p. 1615 - 1626
  作者：Bobrovnikov, M. N.、Turbanova, E. S.、Shishenin, S. A.、Peterleitner, M. G.、Petrov, A. A.

  DOI：——

  日期：——
• Iodocyclization of trifluoromethylallenic phosphonates: an efficient approach to trifluoromethylated oxaphospholenes
  作者：Peng Li、Zhen-Jiang Liu、Jin-Tao Liu

  DOI：10.1016/j.tet.2010.10.040

  日期：2010.12

  alpha-Trifluoromethylallenic phosphonates were prepared by the reaction of diethyl chlorophosphite (DECP) and 4,4,4-trifluorobut-2-yn-1-ols in the presence of Et3N. The iodocyclization of these fluorine-containing allenic phosphonates was achieved with iodine under mild conditions to give the corresponding trifluoromethylated oxaphospholenes in moderate to good yields. (C) 2010 Elsevier Ltd. All rights reserved.