1-(3,5-二甲基-1H-吡唑-1-基)丙-2-胺 | 936940-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-(3,5-二甲基-1H-吡唑-1-基)丙-2-胺
• 中文别名: 1-(3,5-二甲基-1H-吡唑-1-基)-2-丙胺
• 英文名称: 1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-2-amine
• 英文别名: 1-(3,5-dimethylpyrazol-1-yl)propan-2-amine
• CAS: 936940-34-0
• 化学式: C₈H₁₅N₃
• mdl: MFCD04970167
• 分子量: 153.22
• InChiKey: FODFRQFRJYJPSO-UHFFFAOYSA-N

物化性质

• 沸点：
  245.6±28.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933199090
• WGK Germany：
  3

文献信息

• TETRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
  申请人：Dillon Michael Patrick

  公开号：US20150191487A1

  公开（公告）日：2015-07-09

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted tetrazolyl, R 2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R 3 , R 4 , R 5 and R 6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X 3 and/or a P2X 2/3 receptor antagonist and methods of making the compounds.

  化合物的化学式I：或其药用可接受的盐，其中，R1是可选的取代的四氮唑基，R2是可选的取代的苯基，可选的取代的吡啶基或可选的取代的噻吩基，而R3、R4、R5和R6如本文所定义。还提供了使用这些化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关的疾病的方法，以及制备这些化合物的方法。
• Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
  申请人：Dillon Patrick Michael

  公开号：US20080004442A1

  公开（公告）日：2008-01-03

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted tetrazolyl, R 2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R 3 , R 4 , R 5 and R 6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X 3 and/or a P2X 2/3 receptor antagonist and methods of making the compounds.

  公式I的化合物：或其药用盐，其中，R1是可选取代的四唑基，R2是可选取代的苯基，可选取代的吡啶基或可选取代的噻吩基，而R3、R4、R5和R6如本文所定义。还提供了使用这些化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关的疾病的方法，以及制备这些化合物的方法。
• Tetrazole-Substituted Arylamides as P2X3 and P2X2/3 Antagonists
  申请人：Dillon Michael Patrick

  公开号：US20090326220A1

  公开（公告）日：2009-12-31

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted tetrazolyl, R 2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R 3 , R 4 , R 5 and R 6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X 3 and/or a P2X 2/3 receptor antagonist and methods of making the compounds.

  化合物I的公式或其药学上可接受的盐，其中，R1是可选的取代四唑基，R2是可选的取代苯基，可选的取代吡啶基或可选的取代噻吩基，而R3、R4、R5和R6如本文所定义。还提供使用该化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关的疾病的方法以及制备该化合物的方法。
• Tetrazole-substituted arylamides
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2592070A2

  公开（公告）日：2013-05-15

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

  式 I 的化合物： 或其药学上可接受的盐，其中，R1 是任选取代的四唑基，R2 是任选取代的苯基、任选取代的吡啶基或任选取代的噻吩基，R3、R4、R5 和 R6 如本文所定义。还提供了使用这些化合物治疗由 P2X3 和/或 P2X2/3 受体拮抗剂介导的疾病的方法以及制造这些化合物的方法。
• Tetrazole-substituted arylamides as PX2 and PX2/3 antagonists
  申请人：Roche Palo Alto LLC

  公开号：US10201525B2

  公开（公告）日：2019-02-12

  A method of antagonizing P2X3 and/or P2X2/3 receptors or treating a disease misregulation of P2X3 and/or P2X2/3 receptors treating a patient with a compound of formula I wherein R1, R2, R3, R4, R5 and R6 are as defined herein, or a pharmaceutically acceptable salt thereof. wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

  一种拮抗 P2X3 和/或 P2X2/3 受体或治疗 P2X3 和/或 P2X2/3 受体失调疾病的方法 用式 I 的化合物治疗患者 其中，R1、R2、R3、R4、R5 和 R6 如本文所定义，或其药学上可接受的盐。 其中，R1 是任选取代的四唑基，R2 是任选取代的苯基、任选取代的吡啶基或任选取代的噻吩基，R3、R4、R5 和 R6 如本文所定义。还提供了使用这些化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关疾病的方法以及制造这些化合物的方法。