azepan-1-yl-(9-chloro-5,6,7,8-tetrahydro-acridin-3-yl)-methanone | 904444-55-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: azepan-1-yl-(9-chloro-5,6,7,8-tetrahydro-acridin-3-yl)-methanone
• 英文别名: 6-(Azepane-1-carbonyl)-9-chloro-1,2,3,4-tetrahydroacridine；azepan-1-yl-(9-chloro-5,6,7,8-tetrahydroacridin-3-yl)methanone
• CAS: 904444-55-9
• 化学式: C₂₀H₂₃ClN₂O
• 分子量: 342.868
• InChiKey: PEISGDLUWUOZQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7
  申请人：Hybrigenics S.A.

  公开号：EP2357176A1

  公开（公告）日：2011-08-17

  The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.

  本发明涉及发现新的选择性泛素特异性蛋白酶抑制剂、它们的制备过程及其治疗用途。
• Novel Selective Inhibitors of Ubiquitin Specific Protease 7, the Pharmaceutical Compositions Thereof and Their Therapeutic Applications
  申请人：Lopez Roman

  公开号：US20110177105A1

  公开（公告）日：2011-07-21

  The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.

  本发明涉及发现新的选择性抑制泛素特异性蛋白酶的化合物，以及它们的制备方法和治疗用途。
• NOVEL SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS
  申请人：Lopez Roman

  公开号：US20130023521A1

  公开（公告）日：2013-01-24

  The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.

  本发明涉及新型选择性泛素特异性蛋白酶抑制剂的发现，它们的制备过程及其治疗用途。
• AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7
  申请人：Hybrigenics S.A.

  公开号：EP2523938A1

  公开（公告）日：2012-11-21
• US9328093B2
  申请人：——

  公开号：US9328093B2

  公开（公告）日：2016-05-03