1-(4-甲氧基苯基)-N-(1,2,4-三唑-4-基)甲亚胺 | 18998-53-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(4-甲氧基苯基)-N-(1,2,4-三唑-4-基)甲亚胺
• 英文名称: N-[(4'-methoxyphenyl)methylidene]-4H-1,2,4-triazol-4-amine
• 英文别名: N-(4-methoxybenzylidene)-4H-1,2,4-triazole-4-amine；N-(4-methoxybenzylidene)-4H-1,2,4-triazol-4-amine；(4-methoxy-benzylidene)-[1,2,4]triazol-4-yl-amine；markiertes 4--1,2,4-triazol；4--1,2,4-triazol；4-p-Methoxybenzaldimino-1,2,4-triazol；4H-1,2,4-Triazol-4-amine, N-[(4-methoxyphenyl)methylene]-；1-(4-methoxyphenyl)-N-(1,2,4-triazol-4-yl)methanimine
• CAS: 18998-53-3
• 化学式: C₁₀H₁₀N₄O
• mdl: MFCD00160956
• 分子量: 202.216
• InChiKey: BNEVLLSLBKNREQ-UHFFFAOYSA-N

物化性质

• 熔点：
  164 °C
• 沸点：
  376.7±44.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  巯基乙酸 、 1-(4-甲氧基苯基)-N-(1,2,4-三唑-4-基)甲亚胺 在 zinc(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以68%的产率得到2-(4-Methoxyphenyl)-3-(1,2,4-triazol-4-yl)-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Synthesis and Biological Activity of 3-[4H-(1,2,4)-triazolyl]-2-aryl-1,3-thiazolidin-4-ones

  摘要：

  4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2 a-h) in good yields. Cyclocondensation of compounds (2 a-h) with thioglycolic acid yields 3-[4H-(1,2,4)-triazolyl]-2-aryl-1,3-thiazolidin-4-ones (3 a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

  DOI：

  10.1080/10426500801963772
• 作为产物：
  描述：

  4-氨基-1,2,4-三氮唑 、 4-甲氧基苯甲醛 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 1-(4-甲氧基苯基)-N-(1,2,4-三唑-4-基)甲亚胺
  参考文献：
  名称：

  在温和条件下某些4H-1,2,4-三唑的2-氮杂环丁酮衍生物的高效合成和抗菌活性

  摘要：

  我们通过一步法使用1,2,4-三唑的席夫碱合成了新颖的2-氮杂环丁酮衍生物。我们使用DABCO作为良好的均质，环保，高反应性，易于处理且无毒的催化剂。在DABCO催化的活性2-氧-氮杂环丁烷的合成中，高度亲电子的乙烯酮中间体可与弱亲核（N═CH）键反应，用作环加成反应的前体，从而以质子溶剂以优异的产率提供所需的产物。另外，DABCO作为经济上可行的和容易获得的催化剂可溶于几乎所有溶剂中，并且其盐易于从反应介质中滤出。而且，这种新的合成方案具有绿色溶剂中的高转化率和简单的操作步骤的特点。

  DOI：

  10.1002/jhet.3136

文献信息

• Triazole and Benzotriazole Derivatives as Novel Inhibitors for p90 Ribosomal S6 Protein Kinase 2: Synthesis, Molecular Docking and SAR Analysis
  作者：Jun Yuan、Ye Zhong、Shiliang Li、Xue Zhao、Guoqin Luan、Zhenjiang Zhao、Jin Huang、Honglin Li、Yufang Xu

  DOI：10.1002/cjoc.201300443

  日期：2013.7.19

  series of triazole and benzotriazole derivatives as novel p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors were designed and synthesized. The in vitro activities against RSK2 were evaluated, and among 14 compounds, compounds 5, 6, 11, 12, 13 and 14 exhibited enzyme IC50 values of 8.91, 2.86, 3.19, 3.05, 4.49 and 2.09 µmol/L respectively. The proposed binding modes were simulated using molecular docking

  设计并合成了一系列三唑和苯并三唑衍生物，作为新型的p90核糖体S6蛋白激酶2（RSK2）抑制剂。在体外对RSK2活动进行了评价，并且其中14个化合物，化合物5，6，11，12，13和14显示出酶IC 50分别为8.91、2.86、3.19、3.05、4.49和2.09 µmol / L。使用分子对接方法模拟了拟议的结合模式，对接结果与结构-活性关系（SAR）分析表明，所有这些活性化合物均与NTKD上的RSK2 ATP结合位点结合，并且在电子对上具有电子给体基团。苯基的4-位是抑制活性的决定点。
• Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In Vitro and In Silico Study
  作者：Muniza Shaikh、Salman Siddiqui、Humaira Zafar、Uzma Naqeeb、Fakiha Subzwari、Rehan Imad、Khalid M. Khan、Muhammad I. Choudhary

  DOI：10.2174/1573406415666190212105718

  日期：2020.5.20

  Objectives: Two classes of previously synthesized traizole Schiff’s bases (4H-1,2,4-triazole-4- Schiff’s bases 1-14, and 4H-1,2,4-triazole-3-Schiff’s bases 15-23) were evaluated for their in vitro antiglycation activity. Methods: In vitro fructose-mediated human serum albumin (HSA) glycation assay was employed to assess the antiglycation activity of triazole Schiff’s bases. The active compounds were subjected

  背景：已知晚期糖基化终产物（AGEs）与糖尿病并发症，神经退行性疾病和衰老的病理生理有关。预防AGEs的形成可能有助于控制这些疾病。 目的：评估了两类先前合成的曲唑席夫碱（4H-1,2,4-三唑-4-席夫碱1-14和4H-1,2,4-三唑-3-席夫碱15-23）。具有体外抗糖化活性 方法：采用果糖介导的人血清白蛋白（HSA）糖基化体外试验来评估三唑席夫碱的抗糖化活性。通过MTT测定法对小鼠成纤维细胞（3T3）细胞系上的活性化合物进行细胞毒性分析。进行了分子对接和模拟研究，以评估化合物与HSA的相互作用和稳定性。分别通过体外α-葡萄糖苷酶抑制作用和DPPH自由基清除试验评估了选定的非细胞毒性化合物的抗高血糖和抗氧化活性。 结果：来自4H-1,2,4-三唑-4-席夫碱的化合物1（IC50 = 47.30±0.38 µM）具有与标准芦丁（IC50 = 54.5±0.05 µM）相当的抗糖化活性，
• Synthesis and Biological Activity of 3-[4<i>H</i>-(1,2,4)-Triazolyl]-2,6-diaryl-1,3,5-oxadiazine-4-thione
  作者：Hasmukh S. Patel、Ketan B. Patel

  DOI：10.1080/10426500802487789

  日期：2009.9.18

  4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2a-h) in good yield. Rearrangement of compounds (2a-h) with benzoyl isothiocyanate/4-chlorobenzoyl isothiocyanate/2,4-dichloro-benzoyl isothiocyanate yields corresponding 1,3,5-oxadiazine derivatives (3). Structural elucidation of these compounds was based on elementary analysis and spectral data studies. The newly synthesized compounds were evaluated for their antibacterial activities.
• Synthesis of triazole Schiff bases: Novel inhibitors of nucleotide pyrophosphatase/phosphodiesterase-1
  作者：Khalid Mohammed Khan、Salman Siddiqui、Muhammad Saleem、Muhammad Taha、Syed Muhammad Saad、Shahnaz Perveen、M. Iqbal Choudhary

  DOI：10.1016/j.bmc.2014.08.032

  日期：2014.11

  A series of Schiff base triazoles 1-25 was synthesized and evaluated for their nucleotide pyrophosphatase/ phosphodiesterase-1 inhibitory activities. Among twenty-five compounds, three compounds 10 (IC50 = 132.20 +/- 2.89 mu M), 13 (IC50 = 152.83 +/- 2.39 mu M), and 22 (IC50 = 251.0 +/- 6.64 mu M) were identified as potent inhibitors with superior activities than the standard EDTA (IC50 = 277.69 +/- 2.52 mu M). The newly identified inhibitors may open a new avenue for the development of treatment of phosphodiesterase-I related disorders. These compounds were also evaluated for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitory potential and were found to be inactive. The compounds showed non-toxic effect towards PC3 cell lines. (C) 2014 Elsevier Ltd. All rights reserved.
• Mhaske, Sadhana D.; Takate, Sushama J.; Dhawale, Rhushikesh N., Indian Journal of Heterocyclic Chemistry, 2017, vol. 27, # 1, p. 89 - 97
  作者：Mhaske, Sadhana D.、Takate, Sushama J.、Dhawale, Rhushikesh N.、Akolkar, Hemantkumar N.、Randhavane, Pratibha V.、Karale, Bhausaheb K.

  DOI：——

  日期：——