1-(叔丁氧基羰基)-1H-吲哚-5-硼酸 | 317830-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 1-(叔丁氧基羰基)-1H-吲哚-5-硼酸
• 中文别名: N-BOC-吲哚-5-硼酸
• 英文名称: (1-(tert-butoxycarbonyl)-1H-indol-5-yl)boronic acid
• 英文别名: 1-(tert-butoxycarbonyl)-1H-indole-5-boronic acid；[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-5-yl]boronic acid
• CAS: 317830-84-5
• 化学式: C₁₃H₁₆BNO₄
• 分子量: 261.085
• InChiKey: LMSHKSBYXDUUBM-UHFFFAOYSA-N

物化性质

• 沸点：
  443.5±55.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  71.7
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 1-(tert-butoxycarbonyl)-1H-indole-5-boronic acid
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 1-(tert-butoxycarbonyl)-1H-indole-5-boronic acid
CAS number: 317830-84-5

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, under −20◦C.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C13H16BNO4
Molecular weight: 261.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-(叔丁氧基羰基)-1H-吲哚-5-硼酸 在 potassium hydrogen bifluoride 、 nitrosonium tetrafluoroborate 作用下， 以 甲醇 、 水 、 乙腈 为溶剂， 反应 0.04h， 以180 mg的产率得到tert-butyl 5-nitroso-1H-indole-1-carboxylate
  参考文献：
  名称：

  用四氟硼酸亚硝基硝化芳基和杂芳基三氟硼酸盐

  摘要：

  有机三氟硼酸盐已成为用于合成官能化芳基和杂芳基化合物的有毒和空气和水分敏感有机金属物种的替代品。已经表明，三氟硼酸盐部分可以很容易地在合成后期转化为各种不同的取代基。在本文中，我们公开了一种温和的，选择性的和方便的方法为本位使用亚硝鎓四氟硼酸盐（NOBF organotrifluoroborates的-nitrosation 4）。芳基和杂芳基三氟硼酸盐以良好到极好的收率转化为相应的亚硝基产物。这种方法被证明可以容忍广泛的官能团。

  DOI：

  10.1021/jo300551m
• 作为产物：
  描述：

  N-叔丁氧羰基-5-溴吲哚 在 四羟基二硼 、 氯(2-二环己基膦基-2',4',6'-三异丙基-1,1'-联苯基)[2-(2'-氨基-1,1'-联苯)]钯(II) 、 potassium acetate 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 乙醇 为溶剂， 反应 1.5h， 生成 1-(叔丁氧基羰基)-1H-吲哚-5-硼酸
  参考文献：
  名称：

  使用双硼酸的钯催化芳基硼化反应的范围

  摘要：

  Suzuki-Miyaura 反应已成为合成有机化学家更有用的工具之一。直到最近，还没有直接的方法来制造偶联反应中最重要的成分，即硼酸。目前制造硼酸的方法通常使用苛刻或浪费的试剂来制备硼酸衍生物，并且需要额外的步骤来提供所需的硼酸。先前报道的钯催化的直接硼酸合成的范围被揭开，其中包括广泛的合成有用的芳基亲电试剂。它利用新推出的第二代 Buchwald XPhos 预制钯催化剂和双硼酸。为了便于隔离并保留通常敏感的 CB 键，

  DOI：

  10.1021/ja303181m

文献信息

• Src kinase inhibitor compounds
  申请人：Merck & Co., Inc.

  公开号：US06498165B1

  公开（公告）日：2002-12-24

  Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.

  嘧啶化合物（化学式I），或其药用可接受的盐、水合物、溶剂合物、晶型和单一对映异构体，以及包括这些化合物的药物组合物，它们是酪氨酸激酶酶的抑制剂，因此在预防和治疗蛋白酪氨酸激酶相关疾病方面具有用处，如免疫疾病、高增殖性疾病和其他认为不当的蛋白激酶作用可能起作用的疾病，如癌症、血管生成、动脉粥样硬化、移植排斥、类风湿性关节炎和牛皮癣。
• Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid
  作者：He Huang、Chenguang Yu、Xiangmin Li、Yongqiang Zhang、Yueteng Zhang、Xiaobei Chen、Patrick S. Mariano、Hexin Xie、Wei Wang

  DOI：10.1002/anie.201703127

  日期：2017.7.3

  Reported herein is a conceptually novel organocatalytic strategy for the formylation of boronic acids. New reactivity is engineered into the α‐amino‐acid‐forming Petasis reaction occurring between aryl boronic acids, amines, and glyoxylic acids to prepare aldehydes. The operational simplicity of the process and its ability to generate structurally diverse and valued aryl, heteroaryl, and α,β‐unsaturated

  本文报道了用于硼酸甲酰化的概念上新颖的有机催化策略。在芳基硼酸，胺和乙醛酸之间发生的α-氨基酸形成Petasis反应中引入了新的反应性，以制备醛。该方法的操作简便性及其生成结构多样且有价值的包含多种官能团的芳基，杂芳基和α，β-不饱和醛的能力证明了这种新合成策略的实用性。
• Palladium-Catalyzed Borylation of Aryl and Heteroaryl Halides Utilizing Tetrakis(dimethylamino)diboron: One Step Greener
  作者：Gary A. Molander、Sarah L. J. Trice、Steven M. Kennedy

  DOI：10.1021/ol302124j

  日期：2012.9.21

  borylating agent, tetrakis(dimethylamino)diboron [(Me2N)2B–B(NMe2)2], is reported. The method is complementary to the previously reported method utilizing bis-boronic acid (BBA) in that certain substrates perform better under one set of optimized reaction conditions than the other. Because tetrakis(dimethylamino)diboron is the synthetic precursor to both BBA and bis(pinacolato)diboron (B2Pin2), the new

  报道了钯催化芳基和杂芳基卤化物与新型硼酸化剂四（二甲氨基）二硼 [(Me 2 N) 2 B–B(NMe 2 ) 2 ] 的硼化反应。该方法是对先前报道的利用双硼酸 (BBA) 的方法的补充，因为某些底物在一组优化的反应条件下比另一组表现更好。由于四（二甲氨基）二硼是 BBA 和双（频哪醇）二硼（B 2 Pin 2）的合成前体，因此新方法代表了当前硼化方法的原子经济性和效率更高的方法。
• New Synthesis of 1,3-Dihydro-1,4-benzodiazepin-2(2<i>H</i>)-ones and 3-Amino-1,3-dihydro-1,4-benzodiazepin-2(2<i>H</i>)-ones:  Pd-Catalyzed Cross-Coupling of Imidoyl Chlorides with Organoboronic Acids
  作者：Alan Nadin、José M. Sánchez López、Andrew P. Owens、Dean M. Howells、Adam C. Talbot、Timothy Harrison

  DOI：10.1021/jo026860a

  日期：2003.4.1

  A new approach to the synthesis of 1,4-benzodiazepines and 3-amino-1,4-benzodiazepines, which employs the Pd-catalyzed cross-coupling reaction of an imidoyl chloride with an organometallic reagent as the key step, is described. A five-step synthesis of a key intermediate is described and it is shown that in only four further steps (three couplings and a TFA-mediated BOC-deprotection) a wide variety

  描述了一种合成1,4-苯并二氮杂和3-氨基-1,4-苯并二氮杂的新方法，该方法采用Pd催化的酰亚胺基氯与有机金属试剂的交叉偶联反应作为关键步骤。描述了关键中间体的五步合成方法，结果表明，仅在另外四个步骤中（三个偶联和TFA介导的BOC脱保护），各种N1，C3-氨基，C5-碳，或可以合成氮取代的1，4-苯并二氮杂s。
• Cross-Coupling Reactions of Monosubstituted Tetrazines
  作者：Lukas V. Hoff、Simon D. Schnell、Andrea Tomio、Anthony Linden、Karl Gademann

  DOI：10.1021/acs.orglett.1c01813

  日期：2021.8.6

  A Ag-mediated Pd-catalyzed cross-coupling method for 3-bromo-1,2,4,5-tetrazine with boronic acids is presented. Electronic modification of the 1,1′-bis(diphenylphosphine)ferrocene (dppf) ligand was found to be crucial for good turnover. Using this fast method, a variety of alkyl-, heteroatom-, and halide-substituted aryl- and heteroaryl-tetrazines were prepared (29 examples, up to 87% yield).

  提出了一种用于 3-溴-1,2,4,5-四嗪与硼酸的 Ag 介导的 Pd 催化交叉偶联方法。发现 1,1'-双（二苯基膦）二茂铁 (dppf) 配体的电子修饰对于良好的周转至关重要。使用这种快速方法，制备了多种烷基、杂原子和卤化物取代的芳基和杂芳基四嗪（29 个实例，产率高达 87%）。