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1-[2-(4-氯苯基)喹啉-4-基]乙醇 | 6334-29-8

中文名称
1-[2-(4-氯苯基)喹啉-4-基]乙醇
中文别名
——
英文名称
1-[2-(4-Chlorophenyl)quinolin-4-yl]ethanol
英文别名
——
1-[2-(4-氯苯基)喹啉-4-基]乙醇化学式
CAS
6334-29-8
化学式
C17H14ClNO
mdl
——
分子量
283.7
InChiKey
LLUZAYZRXRQYBD-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4
  • 重原子数:
    20
  • 可旋转键数:
    2
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.12
  • 拓扑面积:
    33.1
  • 氢给体数:
    1
  • 氢受体数:
    2

文献信息

  • REPROGRAMMING EFFECTOR PROTEIN INTERACTIONS TO CORRECT EPIGENETIC DEFECTS IN CANCER
    申请人:British Columbia Cancer Agency Branch
    公开号:EP2819662B1
    公开(公告)日:2019-04-10
  • US9552457B2
    申请人:——
    公开号:US9552457B2
    公开(公告)日:2017-01-24
  • [EN] EPIGENETIC REGULATORS AND USES THEREOF<br/>[FR] RÉGULATEURS ÉPIGÉNÉTIQUES ET UTILISATIONS ASSOCIÉES
    申请人:BRITISH COLUMBIA CANCER AGENCY
    公开号:WO2013059944A1
    公开(公告)日:2013-05-02
    Protein chromobox homolog 2 (CBX2) is provided as a target for the development of therapeutics for the treatment of diseases associated with a hyperactive polycomb 2 complex (PRC2), such as lymphomas, lung cancer, breast cancer, prostate cancer and cancers of the neurological system. Compounds of general Formula (I) suitable for use as therapeutics for the treatment of diseases associated with a hyperactive PRC2, for example, diseases characterized by hypermethylation activity of EZH2, are provided. Formula (I)
  • [EN] REPROGRAMMING EFFECTOR PROTEIN INTERACTIONS TO CORRECT EPIGENETIC DEFECTS IN CANCER<br/>[FR] REPROGRAMMATION D'INTERACTIONS ENTRE PROTÉINES EFFECTRICES POUR CORRIGER DES DÉFAUTS ÉPIGÉNÉTIQUES DANS LE CANCER
    申请人:BRITISH COLUMBIA CANCER AGENCY
    公开号:WO2013127011A1
    公开(公告)日:2013-09-06
    Methods of "reprogramming" epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2.
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