1-丙酮,2-(乙酰氧基)-1-(2-甲基苯基)- | 85107-83-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 中文名称: 1-丙酮,2-(乙酰氧基)-1-(2-甲基苯基)-
• 英文名称: N⁶-(p-azidobenzyl)adenosine
• 英文别名: 6-N-(4-azidobenzyl)adenosine；N(6)-(p-Azidobenzyl)adenosine；(2R,3R,4S,5R)-2-[6-[(4-azidophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 85107-83-1
• 化学式: C₁₇H₁₈N₈O₄
• 分子量: 398.381
• InChiKey: LJEKWNMXSDUSRF-LSCFUAHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1-叠氮基-4-(溴甲基)苯 、 腺苷 在 二甲胺 作用下， 生成 1-丙酮,2-(乙酰氧基)-1-(2-甲基苯基)-
  参考文献：
  名称：

  Synthesis of Substituted-Benzyl and Sugar-Modified Analogues of 6-N-(4-Nitrobenzyl)adenosine and Their Interactions with “ES” Nucleoside Transport Systems

  摘要：

  Four classes of 6-X-benzylated purine nucleosides, (i) 6-N-(substituted-benzyl)adenosines, (ii) 6-N-(4-nitrobenzyl)adenine nucleosides with modified sugars, (iii) 6-N(S)-(4-azidobenzy1) derivatives of adenosine, 6-thioinosine, and 6-thioguanosine, and (iv) 6-N-{4-N-[acyl(sulfonyl)amino]benzyl} adenosines, were synthesized and their binding interactions with ''es-NT'' (equilibrative, inhibitor-sensitive nucleoside transport) systems were studied. Several tight-binding analogues were found.

  DOI：

  10.1080/15257779408012177

文献信息

• Synthesis of Substituted-Benzyl and Sugar-Modified Analogues of 6-<i>N</i>-(4-Nitrobenzyl)adenosine and Their Interactions with “<i>ES</i>” Nucleoside Transport Systems
  作者：Morris J. Robins、Jun-ichi Asakura、Masakatsu Kaneko、Susumu Shibuya、Ewa S. Jakobs、Francisca R. Agbanyo、Carol E. Cass、Alan R. P. Paterson

  DOI：10.1080/15257779408012177

  日期：1994.7

  Four classes of 6-X-benzylated purine nucleosides, (i) 6-N-(substituted-benzyl)adenosines, (ii) 6-N-(4-nitrobenzyl)adenine nucleosides with modified sugars, (iii) 6-N(S)-(4-azidobenzy1) derivatives of adenosine, 6-thioinosine, and 6-thioguanosine, and (iv) 6-N-4-N-[acyl(sulfonyl)amino]benzyl} adenosines, were synthesized and their binding interactions with ''es-NT'' (equilibrative, inhibitor-sensitive nucleoside transport) systems were studied. Several tight-binding analogues were found.