1-乙烯基三唑 | 41917-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-乙烯基三唑
• 英文名称: N-vinyl-1,2,3-triazole
• 英文别名: 1-vinyl-1H-1,2,3-triazole；1-Vinyl-1,2,3-triazole；N-vinyltriazole；1-vinyl-1H-[1,2,3]triazole；1-Vinyl-1,2,3-triazol；1-Vinyltriazole；1-ethenyltriazole
• CAS: 41917-22-0
• 化学式: C₄H₅N₃
• 分子量: 95.1038
• InChiKey: GIVBQSUFWURSOS-UHFFFAOYSA-N

物化性质

• 沸点：
  58-59 °C(Press: 1 Torr)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  C-[(tert-butyldiphenylsilyl)oxy]-N-methylnitrone 、 1-乙烯基三唑 以 氯仿 为溶剂， 反应 2.0h， 以13.043%的产率得到
  参考文献：
  名称：

  Synthesis and biological evaluation of 3-hydroxymethyl-5-(1H-1,2,3-triazol) isoxazolidines

  摘要：

  A synthetic approach towards a series of 3-hydroxymethyl-5-(1H-1,2,3-triazol) isoxazolidines has been reported, according to a procedure based on the cycloaddition reaction, under microwave irradiation, of a nitrone with 1-vinyl triazoles, prepared by a click reaction of azides with alkynes. Biological tests show that the synthesized compounds are able to inhibit proliferation of follicular and anaplastic human thyroid cancer cell lines, with IC50 values ranging from 3.87 to 8.76 mu M. The obtained compounds induce caspase-3 activation and DNA fragmentation prevalently in follicular human thyroid cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.10.001
• 作为产物：
  描述：

  2-(4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl)ethyl 4-methylbenzenesulfonate 在 potassium tert-butylate 作用下， 以 叔丁醇 为溶剂， 反应 12.0h， 以88%的产率得到1-乙烯基三唑
  参考文献：
  名称：

  Synthesis and biological evaluation of 3-hydroxymethyl-5-(1H-1,2,3-triazol) isoxazolidines

  摘要：

  A synthetic approach towards a series of 3-hydroxymethyl-5-(1H-1,2,3-triazol) isoxazolidines has been reported, according to a procedure based on the cycloaddition reaction, under microwave irradiation, of a nitrone with 1-vinyl triazoles, prepared by a click reaction of azides with alkynes. Biological tests show that the synthesized compounds are able to inhibit proliferation of follicular and anaplastic human thyroid cancer cell lines, with IC50 values ranging from 3.87 to 8.76 mu M. The obtained compounds induce caspase-3 activation and DNA fragmentation prevalently in follicular human thyroid cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.10.001

文献信息

• Compositions useful as inhibitors of protein kinases
  申请人：Aronov Alex

  公开号：US20050137201A1

  公开（公告）日：2005-06-23

  The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及用于蛋白激酶抑制剂的化合物。该发明还提供了包含该化合物的药学上可接受的组合物，并提供了使用该组合物治疗各种疾病、病况或障碍的方法。
• <i>N</i>-Vinyltriazoles: A New Functional Monomer Family through Click Chemistry
  作者：Hunaid Nulwala、Daniel J. Burke、Anzar Khan、Abigail Serrano、Craig J. Hawker

  DOI：10.1021/ma100011x

  日期：2010.6.22
• Gareev, G. A.; Kirillova, L. P.; Belousov, A. M., Journal of Organic Chemistry USSR (English Translation), 1980, p. 1494 - 1498
  作者：Gareev, G. A.、Kirillova, L. P.、Belousov, A. M.、Bukina, N. S.、Vereshchagin, L. I.

  DOI：——

  日期：——
• ——
  作者：V. N. Kizhnyaev、F. A. Pokatilov、N. A. Tsypina、G. V. Ratovskii、L. I. Vereshchagin、A. I. Smirnov

  DOI：10.1023/a:1020874201056

  日期：——

  Nitro-substituted N-vinyl-1,2,3-triazole derivatives were synthesized by the vinyl exchange reaction. The process was promoted by the catalytic system mercury(II) acetate-trifluoroacetic acid. This system is universal, and it can be used in the synthesis of vinylazoles having two, three, and four nitrogen atoms in the ring.
• VERESHCHAGIN L. I.; TIXONOVA L. G.; MAKSIKOVA A. V.; GAVRILOV L. D.; GARE+, ZH. ORGAN. XIMII, 1979, 15, HO 3, 612-618
  作者：VERESHCHAGIN L. I.、 TIXONOVA L. G.、 MAKSIKOVA A. V.、 GAVRILOV L. D.、 GARE+

  DOI：——

  日期：——