1-吡咯烷羧酸,3-[[3-(4-吗啉基)丙基]氨基]-,1,1-二甲基乙基酯 | 51846-98-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-吡咯烷羧酸,3-[[3-(4-吗啉基)丙基]氨基]-,1,1-二甲基乙基酯
• 中文别名: 抗生素Ji20B
• 英文名称: Antibiotic JI 20B
• 英文别名: 2-[4,6-diamino-3-[3-amino-6-(1-aminoethyl)-4,5-dihydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
• CAS: 51846-98-1
• 化学式: C₂₀H₄₁N₅O₉
• 分子量: 495.6
• InChiKey: WYJSPPYVEJPMJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  254
• 氢给体数：
  10
• 氢受体数：
  14

文献信息

• Suppressors of Premature Termination Codons as Therapeutics and Methods for Their Use
  申请人：The University of British Columbia

  公开号：US20180258123A1

  公开（公告）日：2018-09-13

  This invention discloses the use of aminoglycoside antibiotics such as gentamicin B1 to suppress premature termination codons during translation and promote the full length read-through of transcripts such as p53 that incorporate nonsense mutations and to treat disease conditions such as cancer caused by such genetic mutations.
• [EN] SUPPRESSORS OF PREMATURE TERMINATION CODONS AS THERAPEUTICS AND METHODS FOR THEIR USE<br/>[FR] SUPPRESSEURS DE CODONS DE TERMINAISON PRÉMATURÉS EN TANT QU'AGENTS THÉRAPEUTIQUES ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2017049386A1

  公开（公告）日：2017-03-30

  This invention discloses the use of aminoglycoside antibiotics such as gentamicin Bl to suppress premature termination codons during translation and promote the full length read-through of transcripts such as p53 that incorporate nonsense mutations and to treat disease conditions such as cancer caused by such genetic mutations.