氟酰胺 | 66332-96-5

• 物质功能分类: 化学农药原药 - 杀菌剂 - 其他杀菌剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氟酰胺
• 中文别名: 氟担菌宁,N-(3'-异丙氧基苯基)-2-三氟甲基苯甲酰胺；氟担菌宁；3'-异丙氧基-2-(三氟甲基)苯甲酰苯胺；望佳多；氟纹胺；纹枯胺；N-(3’-异丙氧基苯基)-2-三氟甲基苯甲酰胺
• 英文名称: flutolanil
• 英文别名: α,α,α-trifluoro-3'-isopropoxy-o-toluanilide；N-(3-(1-methylethoxy)phenyl)-2-(trifluoromethyl)benzamide；N-[3-(propan-2-yloxy)phenyl]-2-(trifluoromethyl)benzamide；3'-isopropoxy-2-trifluoromethyl benzoic acid anilide；3’-isopropoxy-2-(trifluoromethyl)benzanilide；N-(3'-isopropoxyphenyl)-2-trifluoromethylbenzamide；N-(3-propan-2-yloxyphenyl)-2-(trifluoromethyl)benzamide
• CAS: 66332-96-5
• 化学式: C₁₇H₁₆F₃NO₂
• 分子量: 323.315
• InChiKey: PTCGDEVVHUXTMP-UHFFFAOYSA-N

物化性质

• 熔点：
  108° (Araki, Yabutani); mp 104-105° (Araki, 1985)
• 沸点：
  339.1±42.0 °C(Predicted)
• 密度：
  1.2463 (estimate)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）
• LogP：
  3.700
• 物理描述：
  COLOURLESS-TO-WHITE CRYSTALS.
• 颜色/状态：
  White, crystalline solid
• 蒸汽压力：
  1.33X10-5 mm Hg at 25 °C
• 稳定性/保质期：
  Stable under recommended storage conditions.
• 分解：
  When heated to decomposition it emits toxic vapors of nitrogen oxides and fluorides.
• 碰撞截面：
  175.45 Ų [M+H]+ [CCS Type: TW]
• 保留指数：
  2140.4

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.235
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  5

ADMET

毒理性

• 毒性总结

鉴定和使用：Flutolantil 是一种固体。它对Basidiomycetes类真菌有作用。它被用作叶面杀菌剂，用于控制大麦上的Typhula病害和水稻的鞘腐病，也被用作种子处理剂，以防止马铃薯和葫芦科植物上的Rhizoctonia solani病害。人类暴露和毒性：Flutolanil 在人类乳腺癌细胞中表现出雌激素活性。在人类淋巴细胞的裂变活性试验中观察到阴性结果。动物研究：在兔子身上，1小时后观察到结膜红肿，48小时后仍有4只动物出现红肿。所有眼睛在72小时内恢复正常。Flutolanil 在小鼠、大鼠和狗身上未表现出致癌性。在一项大鼠的生殖毒性两代研究中，Flutolanil 未显示出特定的生殖效应。唯一的一般毒性迹象，即肝脏重量增加，在两代父母中出现的频率相似。Flutolanil 已经在体外的一系列试验中测试了其基因毒性，并在体内对小鼠骨髓中的微核进行了测试。在细菌反向突变、细菌DNA修复、哺乳动物基因突变、大鼠肝细胞中的非计划性DNA合成以及体内染色体效应（微核诱导）的试验中观察到阴性结果。在中国仓鼠肺细胞中，存在代谢激活的情况下，染色体畸变的试验中报告了一个弱阳性结果。生态毒性研究：在D. magna中，flutolanil 在不到LC50（8天）一半的浓度下显著减小了第一代幼体的体积。Flutolanil 对斑马鱼胚胎的亚致死效应包括生长抑制、异常自发运动、心率减慢、完全孵化失败和形态畸形。此外，flutolanil 还可导致幼虫的脊索变形和体长缩短。

IDENTIFICATION AND USE: Flutolantil is a solid. It acts against Basidiomycetes. It is used as a foliar fungicide for the control of Typhula on barley and sheath blight on rice, as well as a seed dressing against Rhizoctonia solani on potatoes and cucurbits. HUMAN EXPOSURE AND TOXICITY: Flutolanil exhibits estrogenic activities in human breast cancer cells. Negative results were seen in assays for clastogenicity in human lymphocytes. ANIMAL STUDIES: Conjunctival redness was seen in rabbits at 1 hr, and the redness was still present at 48 hr in four animals. All eyes were normal by 72 hr. Flutolanil was not carcinogenic in mice, rats and dogs. Flutolanil showed no specific reproductive effects in a two-generation study of reproductive toxicity in rats. The only sign of general toxicity, increased liver weight, occurred at similar frequency in both generations of parents. Flutolanil has been tested for genotoxicity in a range of assays in vitro and in an assay for micronuclei in bone marrow of mice treated in vivo. Negative results were seen in assays for bacterial reverse mutation, bacterial DNA repair, mammalian gene mutation, unscheduled DNA synthesis in rat hepatocytes, and chromosomal effects (micronucleus induction) in vivo. A weak positive result was reported in an assay for chromosomal aberration in Chinese hamster lung cells in the presence of metabolic activation. ECOTOXICITY STUDIES: In D. magna flutolanil significantly reduced the size of the first brood at concentrations less than half of those for LC50 (8 days). Sublethal effects induced by flutolanil on zebrafish embryos were noted, including growth inhibition, abnormal spontaneous movement, slower heart rate, complete hatching failure, and morphological deformities. In addition, flutolanil could cause notochord deformation and short body length of larvae.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：人类非致癌性证据E组

Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者向前倾或放在左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预防癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在1992年进行的一项研究中，将[苯环-U-14C]氟托拉尼（具体活性；20 mCi/mmol；放射性纯度，>99%）悬浮在由1% Tween 80和0.5%羧甲基纤维素组成的载体中，口服给予每组三只雄性和三只雌性CD（Sprague-Dawley衍生）大鼠。还使用了未标记的氟托拉尼（纯度，99.9%或97.6%）来制备溶液。动物接受了20 mg/kg bw [14C]氟托拉尼的单次剂量；连续14天每天20 mg/kg bw未标记氟托拉尼的剂量，然后在第15天给予单次剂量的[14C]氟托拉尼；或者单次剂量1000 mg/kg [14C]氟托拉尼。给药后，第1天收集三次尿液，然后每天收集；每天收集粪便和笼子清洗液。在收集样本的第7天，处死动物，并获取血液和12个组织样本。通过适当的处理后，使用液体闪烁计数法确定样本中的放射性。由于较早的研究表明<0.1%的剂量已被呼出，因此未确定挥发性14C的产生。在较低剂量下，总回收率是可以接受的，但在较高剂量下<90%。大部分放射性在24小时内被排出，大约一半的尿排泄发生在12小时内，这表明相对较快的吸收。根据尿排泄确定的吸收程度随着剂量和重复给药而变化，这表明大剂量给药会导致吸收饱和。有证据表明，重复给药诱导了氟托拉尼的代谢。两种性别中发现了类似的结果。在7天内，血液和组织中的放射性浓度和分布最小，代表任何动物给药量的<0.2%，这表明没有显著的生物积累潜力。同一组内不同动物的组织浓度差异很大。唯一一个持续浓度发现的组织是肝脏，其平均浓度约为血液中的10倍。在所有组中，雌性肝脏中的放射性物质含量高于雄性（1000 mg/kg bw时为2.4 +/- 1.1比0.68 +/- 0.38 ug/g；重复剂量后为0.23 +/- 0.04比0.12 +/- 0.01 ug/g）。

In a study performed in 1992, [aniline ring-U-14C]flutolanil (specific activity; 20 mCi/mmol; radiochemical purity, >99%) suspended in a vehicle consisting of 1% Tween 80 and 0.5% carboxymethyl cellulose was given orally to groups of three male and three female CD (Sprague-Dawley-derived) rats. Unlabelled flutolanil (purity, 99.9% or 97.6%) was also used in preparation of the solutions. The animals received either a single dose of 20 mg/kg bw [14C]flutolanil; consecutive doses of 20 mg/kg bw per day of unlabelled flutolanil for 14 days followed by single dose of [14C]flutolanil on day 15; or a single dose of 1000 mg/kg [14C]flutolanil. After administration, urine was collected three times on day 1, then daily; and feces and cage wash were collected daily. After sample collection on day 7, the animals were killed, and blood and 12 tissue samples were obtained. The radioactivity in the samples was determined by liquid scintillation counting after appropriate processing. Volatile 14C production was not determined as an earlier study showed that <0.1% of the dose had been exhaled. The total recovery was acceptable at the lower dose but was <90% at the higher dose. Most of the radioactivity was excreted within 24 hr, approximately half the urinary excretion occurring within 12 hr, indicating relatively rapid absorption. The extent of absorption, as determined by urinary excretion, varied with dose and repeated dosing, indicating saturation of absorption by large doses. There was evidence of induction of flutolanil metabolism by repeated dosing. Similar results were found in the two sexes. The concentration and distribution of radioactivity in blood and tissues at 7 days was minimal, representing <0.2% of that administered to any animal, indicating no significant potential for bioaccumulation. The tissue concentrations varied considerably between animals in the same group. The only tissue in which consistent concentrations were found was the liver, in which the mean was about 10 times those in blood. The amount of radioactivity in the livers was higher in females in all groups than in males (2.4 +/- 1.1 versus 0.68 +/- 0.38 ug/g at 1000 mg/kg bw; 0.23 +/- 0.04 versus 0.12 +/- 0.01 ug/g after repeated doses).

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在一项研究中，将氟托烷胺添加到斯普拉格-道利大鼠的饮食中，持续4周，对大脑、肝脏、血液、肾脏和脂肪的分析显示，接受>2000 ppm剂量的大鼠体内浓度较低。残留物最高浓度在脂肪组织和肝脏中找到。氟托烷胺的保留最小。最低剂量400 ppm相当于雄性每天36 mg/kg体重，雌性每天41 mg/kg体重。将400 ppm的结果与另一项研究中20 mg/kg体重的结果进行比较，表明氟托烷胺没有显著的积累倾向。随着剂量的增加，残留物浓度的增加表明，灌胃给药后观察到的吸收饱和现象在饮食摄入后不会发生。

In a study in which flutolanil was given in the diet to Sprague-Dawley rats for 4 weeks, analyses of brain, liver, blood, kidney and fat showed low concentrations in animals receiving >2000 ppm. The highest concentrations of residues were found in adipose tissue and liver. There was minimal retention of flutolanil. The lowest dose of 400 ppm was equal to 36 mg/kg bw per day in males and 41 mg/kg bw per day in females. Comparison of the results at 400 ppm with those at 20 mg/kg bw in /another study/ indicated that flutolanil that has no significant propensity to accumulate. The increase in residue concentration with increasing dose indicated that the saturation of absorption seen after administration by gavage does not occur after dietary intake.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

对给予重复剂量的老鼠的研究中取样的组织样本分析显示，氟菌清仅在脂肪中存在，并且浓度较低：在2000 ppm剂量下为0.2 ppm，在10000 ppm剂量下为0.6 ppm，这与单次给药后发现的浓度相似。由于分析方法仅针对母化合物，任何可能对单次给药后残留物有贡献的代谢物将不会被检测到。然而，由于从氟菌清形成的代谢物相对极性，并且主要通过尿液排出，重复剂量研究的结果表明氟菌清几乎不具有生物累积的潜力。

An analysis of tissue samples from the study in rats given repeated doses showed that flutolanil was present only in fat and at low concentrations: 0.2 ppm at 2,000 ppm and 0.6 ppm at 10,000 ppm, which are similar to those found after a single dose. As the analytical method was only for the parent compound, any metabolites that might have contributed to the residues after a single dose would not have been detected. However, as the metabolites formed from flutolanil are relatively polar and are excreted primarily in urine, the findings from the study with repeated doses indicate that flutolanil has little if any potential to bioaccumulate.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• RTECS号：
  CV5581320
• 海关编码：
  2924299033

制备方法与用途

毒性

大鼠和小鼠急性经口LD₅₀大于10000毫克/公斤，急性经皮在5000毫克/公斤剂量时表现为无毒，对皮肤和黏膜的刺激性很轻微。鲤鱼LC₅₀为2.4毫克/升（48小时）。

化学性质

纯品为白色无臭结晶体，熔点108℃（102～103℃），蒸汽压为1.77×10⁻⁹帕斯卡（20℃）。在20℃时的溶解度为：丙酮642克/升，甲醇606克/升（480克/升），氯仿341克/升（238克/升），甲苯56克/升（65克/升），二甲苯29克/升，己烷3克/升，水9.6毫克/升。分配系数为3.7，在pH值3～9的水溶液中稳定，在100℃加热5小时或50℃放置14天无分解。在日光灯（17000勒克斯、96小时）照射下，分解率为1%，说明其对热和光具有较好的稳定性。在土壤中的半衰期为40～60天。

用途

氟担菌宁属于苯甲酰胺衍生物，是一种内吸性杀菌剂，用于预防和治疗某些担子菌纲真菌引起的疾病。它能强烈阻碍菌丝的生育和侵入菌丝块的形成。例如，在50毫克/升浓度下进行茎叶处理可以完全防治由丝核菌引起的水稻纹枯病。

用途

氟担菌宁是一种内吸杀菌剂，对水稻纹枯病、马铃薯黑痣病等有效。

生产方法

邻三氟甲基氯苯经格氏反应、羰基化和水解得到邻三氟甲基苯甲酸。然后进行酰氯化反应，并与间异丙氧基苯胺反应制得氟担菌宁。

制备方法一

邻三氟甲基苯甲酰氯可用邻三氟甲基氯苯为原料，经过格氏反应，然后与干冰反应羰基化，再经水解得邻三氟甲基苯甲酸。该酸经酰氯化制得邻三氟甲基苯甲酰氯。在冰冷却下，将邻三氟甲基苯甲酰氯加到四氢呋喃中，在三乙胺存在下及室温条件下与间异丙氧基苯胺反应2小时，得到氟担菌宁。

制备方法二

氟担菌宁也可通过3-（2-三氟甲基苯甲酰氨基）苯酚与2-氯代丙烷反应制得。

类别

农药

毒性分级

低毒

急性毒性

口服 - 大鼠 LD₅₀: 10000 毫克/公斤；小鼠 LD₅₀: 10000 毫克/公斤

可燃性危险特性

可燃；燃烧会产生有毒的氮氧化物和氯化物气体

储运特性

库房应通风、低温干燥，并与食品原料分开储运

灭火剂

干粉、泡沫、砂土

上下游信息

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  ——	3'-hydroxy-2-(trifluoromethyl)benzanilide	69392-32-1	C14H10F3NO2	281.234
  2-(三氟甲基)苯甲酰胺	2-(trifluoromethyl)benzamide	360-64-5	C8H6F3NO	189.137

反应信息

• 作为反应物：
  描述：

  氟酰胺 反应 100.0h， 生成 3'-hydroxy-2-(trifluoromethyl)benzanilide 、 2'-amino-4'-isopropoxyphenyl 2-trifluoromethyl ketone
  参考文献：
  名称：

  Tsao, Rong; Eto, Morifusa, Agricultural and Biological Chemistry, 1991, vol. 55, # 3, p. 763 - 768

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氨基苯异丙醚 、 2-三氟甲基苯甲酰氯 在 三乙胺盐酸盐 、 三乙胺 作用下， 以 四氢呋喃 、 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 为溶剂， 以91%的产率得到氟酰胺
  参考文献：
  名称：

  Novel benzoic anilide derivative and fungicide containing same

  摘要：

  由o-三氟甲基苯甲酸和m-异丙氧基苯胺反应形成的O-三氟甲基苯甲酰m'-异丙氧基苯胺，在控制农业和园艺植物病害方面非常有效。

  公开号：

  US04093743A1
• 作为试剂：
  描述：

  5-{3-[(2,3-dihydrobenzofuran-5-yl)-difluoromethyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}thiophene-2-carboxylic acid ethyl ester 、 sodium hydroxide 、 O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate 、 1-羟基苯并三唑 、 N,N-二异丙基乙胺 、 N-甲基哌嗪 在 水 、 N,N-二甲基甲酰胺 、 二氯甲烷 、 magnesium sulfate 、 氟酰胺 、 acetonitrile-water 、 final compound 、 HCO3 作用下， 以 tetrahydrofuran methanol 、 二氯甲烷 、 水 为溶剂， 反应 3.5h， 生成 (5-{3-[(2,3-dihydrobenzofuran-5-yl)difluoromethyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}thiophen-2-yl)-(4-methylpiperazin-1-yl)methanone
  参考文献：
  名称：

  TRIAZOLOPYRIDAZINES AS KINASE MODULATORS

  摘要：

  本发明涉及式I的三唑并吡嗪化合物：其中R1，R5，R6，R7，R8和A如本文所定义，所述化合物的用途为蛋白酪氨酸激酶调节剂，特别是c-Met的抑制剂，并且所述化合物的用途为减少或抑制细胞或受体中c-Met的激酶活性，并调节细胞或受体中c-Met的表达，以及使用该化合物预防或治疗细胞增殖性疾病和/或与c-Met相关的疾病。本发明还涉及包含本发明化合物的药物组合物，以及治疗肿瘤和其他细胞增殖性疾病的方法。

  公开号：

  US20070203136A1

文献信息

• [EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
  申请人：GILEAD APOLLO LLC

  公开号：WO2017075056A1

  公开（公告）日：2017-05-04

  The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了化合物I和II，这些化合物可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及它们的组合物和使用方法。
• [EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
  申请人：BASF SE

  公开号：WO2014206910A1

  公开（公告）日：2014-12-31

  The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及公式（I）中变量如索权和说明中所定义的自行车基取代异噻唑啉化合物。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种通过使用这些化合物来控制无脊椎动物害虫的方法，以及包含所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] AZOLINE COMPOUNDS<br/>[FR] COMPOSÉS AZOLINE
  申请人：BASF SE

  公开号：WO2015128358A1

  公开（公告）日：2015-09-03

  The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及式（I）的噁唑啉化合物，其中A、B1、B2、B3、G1、G2、X1、R1、R3a、R3b、Rg1和Rg2如权利要求和描述中所定义。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种利用这些化合物控制无脊椎动物害虫的方法，以及包括所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] SUBSTITUTED QUINAZOLINES AS FUNGICIDES<br/>[FR] QUINAZOLINES SUBSTITUÉES, UTILISÉES EN TANT QUE FONGICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2010136475A1

  公开（公告）日：2010-12-02

  The present invention relates to a compound of formula (I) wherein wherein the substituents have the definitions as defined in claim 1or a salt or a N-oxide thereof, their use and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.

  本发明涉及一种具有如下式（I）的化合物，其中取代基具有权利要求1中定义的定义，或其盐或N-氧化物，它们的用途以及用于控制和/或预防植物中微生物感染，特别是真菌感染的方法，以及制备这些化合物的方法。
• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。

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