1-氯-4-乙氧基丁烷 | 36865-43-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-氯-4-乙氧基丁烷
• 中文别名: 4-乙氧基氯丁烷；4-氯丁基乙基醚
• 英文名称: ethyl 4-chlorobutyl ether
• 英文别名: 4-Chlorbutyl-ethylether；1-Chlor-4-aethoxy-butan；4-Chlor-1-ethoxy-butan；1-chloro-4-ethoxybutane；Aethyl-(4-chlor-butyl)-aether；1-Aethoxy-4-chlor-butan
• CAS: 36865-43-7
• 化学式: C₆H₁₃ClO
• 分子量: 136.622
• InChiKey: IXRDURXALZYREB-UHFFFAOYSA-N

物化性质

• 沸点：
  157.0-157.5 °C
• 密度：
  0.9603 g/cm3
• 保留指数：
  913.7;915.2

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909199090

反应信息

• 作为反应物：
  描述：

  1-氯-4-乙氧基丁烷 在 水 、 sodium sulfite 作用下， 生成 4-ethoxy-butane-1-sulfonic acid
  参考文献：
  名称：

  The Chemistry of Sultones. II. Alkylations of Organometallic and Related Compounds by Sultones¹

  摘要：

  DOI：

  10.1021/ja01614a041
• 作为产物：
  描述：

  4-乙氧基-1-丁醇 在 氯化亚砜 作用下， 生成 1-氯-4-乙氧基丁烷
  参考文献：
  名称：

  622.一些新的哌替啶类似物。第三部分 1-芳氧基-烷基norpethidines，和类似的类似物

  摘要：

  DOI：

  10.1039/jr9580003065

文献信息

• Towards Selective Ethylene Tetramerization
  作者：Sebastiano Licciulli、Indira Thapa、Khalid Albahily、Ilia Korobkov、Sandro Gambarotta、Robbert Duchateau、Reynald Chevalier、Katrin Schuhen

  DOI：10.1002/anie.201003465

  日期：2010.11.22

  And the magic number is …︁ 4! A large amount of oligomer‐free 1‐octene (99.9 %) was produced from ethylene by a catalytic system based on chromium during the formation of polyethylene wax [see GC–MS chromatogram; the other three significant peaks are methanol (quenching agent), ethyl acetate (needle‐rinsing agent), and toluene (solvent)].

  魔幻数字是……︁4！在聚乙烯蜡的形成过程中，基于铬的催化体系由乙烯产生了大量的无低聚物1-辛烯（99.9％）[见GC-MS色谱图；其他三个重要峰是甲醇（淬灭剂），乙酸乙酯（针洗剂）和甲苯（溶剂）]。
• Reaction of Alkyl Halides with Mercury(II) Salts in Tetrahydrofuran. A Facile Preparation of 4-Alkoxybutyl Acetates and Chlorides
  作者：Nanao Watanabe、Sakae Uemura、Masaya Okano

  DOI：10.1246/bcsj.49.2500

  日期：1976.9

  The reaction of primary and secondary alkyl iodides and bromides with Hg(OAc)2 and HgCl2 in tetrahydrofuran (THF) affords the THF-incorporated compounds (1), RO(CH2)4X [X=OAc and Cl, respectively], in good yields. When HgBr2 and aqueous or alcoholic Hg(ClO4)2 were used as mercury(II) salts, the yields of 1(X=Br, OH, and OR′) were low. Similar treatment with HgI2 gave scarcely any 1. A reaction scheme

  伯和仲烷基碘化物和溴化物与 Hg(OAc)2 和 HgCl2 在四氢呋喃 (THF) 中的反应得到掺入 THF 的化合物 (1)，RO(CH2)4X [X=OAc 和 Cl，分别]产量。当 HgBr2 和水或醇 Hg(ClO4)2 用作汞 (II) 盐时，1(X=Br、OH 和 OR') 的产率很低。用 HgI2 进行类似处理几乎没有得到任何 1。 提出了一种涉及 O-烷基四氢呋喃离子作为中间体的反应方案，用于形成 1。
• Substituted 4-phenyl-4-piperidinecarboxamides with both local
  申请人：Aktiebolaget Astra

  公开号：US05227389A1

  公开（公告）日：1993-07-13

  Compounds of the formula IV for use as local anesthesia and analgesia, as well as a method for their preparation, their pharmaceutical preparations and their use. ##STR1##

  公式IV的化合物可用作局部麻醉和止痛，以及它们的制备方法，它们的制药制剂和它们的用途。 ## STR1 ##
• 6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
  申请人：——

  公开号：US20030105098A1

  公开（公告）日：2003-06-05

  The present invention comprises 6-9-Disubstituted 2-[trans-(4-aminocyclohexyl]aminopurines that are useful in inhibiting cyclin dependent kinases, particularly cdk-2. The present invention also provides a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms.

  本发明涉及6-9-二取代的2- [转-（4-氨基环己基）]氨基嘌呤，其在抑制细胞周期依赖性激酶，特别是cdk-2方面具有用途。本发明还提供了一种预防神经细胞凋亡和抑制肿瘤发展的方法。
• 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
  申请人：Aventis Pharmaceuticals Inc.

  公开号：US06479487B1

  公开（公告）日：2002-11-12

  The present invention provides novel compounds of the formula (I) wherein R is selected from the group consisting of R2, R2NH—, or R3R4N—R5- wherein R2 is selected from the group consisting of C9-C12 alkyl, Z is selected from the group consisting of phenyl, heterocycle, cycloalkyl, and naphthanlene; and M is selected from the group consisting of hydrogen, C1-C4 alkyl, and wherein each C9-C12 alkyl or Z is optionally substituted with 1 to 3 substituents, which may be the same or different, and which are selected from the group consisting of D, E, wherein each D is independently selected from the group consisting of trifluoromethyl, trifluoromethoxy, and C1-C4 alkoxy; each E is independently selected from the group consisting of Hal, OH, and C1-C8 alkyl; R3 and R4 are selected from the group consisting of hydrogen, C1-C4 alkyl and (CH2)y-phenyl, wherein y is an integer 0-8, with the proviso that R3 and R4 not both be hydrogen; R5 is C1-C8 alkylene; and R1 is selected from the group consisting of cyclopentyl, cyclopentenyl and isopropyl, and the pharmaceutically acceptable salts, optical isomers, and hydrates thereof, with the proviso that when R2 is the group wherein n is 1 or greater; R1 is isopropyl or cyclopentyl; R6 is hydrogen, C1-C4 alkyl, or (CH2)m-phenyl; and Z is phenyl, heterocycle, or cycloalkyl, that Z is substituted with 1 to 3 substituents, which may be the same or different, and which are selected from the group consisting of In addition, the present invention provides a method of inhibiting cyclin dependent kinases, particularly cdk-2. The present invention also provides a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms.

  本发明提供了公式(I)的新化合物，其中R选自R2、R2NH-或R3R4N-R5-组成的群，其中R2选自C9-C12烷基，Z选自苯基、杂环、环烷基和萘基；M选自氢、C1-C4烷基和其中每个C9-C12烷基或Z可选择地被1-3个取代基取代，这些取代基可以相同也可以不同，选自D、E组成的群，其中每个D独立地选自三氟甲基、三氟甲氧基和C1-C4烷氧基；每个E独立地选自卤素、羟基和C1-C8烷基；R3和R4选自氢、C1-C4烷基和(CH2)y-苯基，其中y是0-8的整数，但R3和R4不能同时为氢；R5是C1-C8烷基；R1选自环戊基、环戊烯基和异丙基，以及其药学上可接受的盐、光学异构体和水合物，但当R2为n为1或更大的基团时；R1为异丙基或环戊基；R6为氢、C1-C4烷基或(CH2)m-苯基；Z为苯基、杂环或环烷基，但Z被1-3个取代基取代，这些取代基可以相同也可以不同，选自此外，本发明提供了一种抑制细胞周期依赖性激酶，特别是cdk-2的方法。本发明还提供了一种预防神经细胞凋亡和抑制肿瘤发展的方法。

表征谱图