(E)-2-cyano-3-(3,4-difluorophenyl)prop-2-enoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-2-cyano-3-(3,4-difluorophenyl)prop-2-enoic acid
• 化学式: C₁₀H₅F₂NO₂
• 分子量: 209.15
• InChiKey: KPLURQICSKMSJX-XVNBXDOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE LA POUSSE DES CHEVEUX
  申请人：UNIV CALIFORNIA

  公开号：WO2019006359A1

  公开（公告）日：2019-01-03

  The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

  本公开涉及能够抑制线粒体丙酮酸载体并促进头发生长的化合物。该公开还涉及促进头发生长或治疗影响头发生长的状况或疾病的方法，如秃头或脱发。
• Compositions and methods for modulating hair growth
  申请人：The Regents of the University of California

  公开号：US11312714B2

  公开（公告）日：2022-04-26

  The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

  本公开涉及能够抑制线粒体丙酮酸载体并促进毛发生长的化合物。本公开进一步涉及促进毛发生长或治疗影响毛发生长的条件或疾病（如秃头或脱发）的方法。
• COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH
  申请人：The Regents of the University of California

  公开号：EP3644989A1

  公开（公告）日：2020-05-06
• [EN] SYNTHESIS OF COMPOUNDS TO PROMOTE HAIR GROWTH<br/>[FR] SYNTHÈSE DE COMPOSÉS POUR FAVORISER LA CROISSANCE CAPILLAIRE
  申请人：THE REGENT OF THE UNIV OFCALIFORNIA

  公开号：WO2021127482A1

  公开（公告）日：2021-06-24

  The present disclosure relates to a method of synthesizing a compound represented by formula I. The present disclosure further relates to formula I (A, B, or C) compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth.