1-烯丙基环己基氨基甲酸酯 | 90978-25-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-烯丙基环己基氨基甲酸酯
• 英文名称: carbamic acid-(1-allyl-cyclohexyl ester)
• 英文别名: Carbamidsaeure-(1-allyl-cyclohexylester)；(1-Prop-2-enylcyclohexyl) carbamate
• CAS: 90978-25-9
• 化学式: C₁₀H₁₇NO₂
• 分子量: 183.25
• InChiKey: YNKJCTDSENBDOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-烯丙基环己基氨基甲酸酯 在 lithium hydroxide 、 potassium osmate(VI) 、 次氯酸叔丁酯 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 丙醇 、 sodium hydroxide 、 水 为溶剂， 生成 (2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl-hexadeca-2,4,6,12-tetraenoic acid [2-(1-hydroxy-cyclohexyl)-1-hydroxymethyl-ethyl]-amide
  参考文献：
  名称：

  The preparation of simplified scyphostatin analogues using a tethered aminohydroxylation (TA) strategy

  摘要：

  The first tethered aminohydroxylation reaction employing a tertiary alcohol is reported as part of a route to prepare analogues of the naturally occurring sphingomyelinase inhibitor, scyphostatin. The tethered aminohydroxylation of 1-allylcyclohexanol produces the beta-amino alcohol product, in protected form, with the required regiochemistry. Two approaches to the installation of the lipophilic side chain are described and the successful route used to prepare five novel scyphostatin analogues, one containing the natural lower side chain. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.07.012
• 作为产物：
  描述：

  1-烯丙基环己醇 生成 1-烯丙基环己基氨基甲酸酯
  参考文献：
  名称：

  The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep

  摘要：

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.

  DOI：

  10.1080/08964280109595773

文献信息

• The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep
  作者：June J. Pilcher、Kristin R. Michalowski、Renee D. Carrigan

  DOI：10.1080/08964280109595773

  日期：2001.1

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.
• The preparation of simplified scyphostatin analogues using a tethered aminohydroxylation (TA) strategy
  作者：Martin N. Kenworthy、Graeme D. McAllister、Richard J.K. Taylor

  DOI：10.1016/j.tetlet.2004.07.012

  日期：2004.8

  The first tethered aminohydroxylation reaction employing a tertiary alcohol is reported as part of a route to prepare analogues of the naturally occurring sphingomyelinase inhibitor, scyphostatin. The tethered aminohydroxylation of 1-allylcyclohexanol produces the beta-amino alcohol product, in protected form, with the required regiochemistry. Two approaches to the installation of the lipophilic side chain are described and the successful route used to prepare five novel scyphostatin analogues, one containing the natural lower side chain. (C) 2004 Elsevier Ltd. All rights reserved.