1-甲基-1H-四唑-5-硫醇钾 | 62557-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-甲基-1H-四唑-5-硫醇钾
• 英文名称: potassium 5-mercapto-1-methyltetrazole
• 英文别名: 1-methyl-5-mercapto-1,2,3,4-tetrazole potassium salt；(1-methyltetrazol-5-yl)sulfanyl potassium；potassium 1-methyl-1H-tetrazole-5-thiolate；potassium;1-methyltetrazole-5-thiolate
• CAS: 62557-28-2
• 化学式: C₂H₃N₄S*K
• 分子量: 154.237
• InChiKey: HFRHYYFCSVBNPW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.88
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-甲基-1H-四唑-5-硫醇钾 在 碘 作用下， 以 甲醇 为溶剂， 以70%的产率得到5,5-二硫代双(1-甲基四唑)
  参考文献：
  名称：

  COMPOUND HAVING HEPTAMETHINE STRUCTURE, SENSITIZING DYE AND PHOTOELECTRIC CONVERSION ELEMENT

  摘要：

  提供的是一种具有七甲基结构的化合物，其通式如下（1），用作光电转换装置的敏化染料，以及使用该化合物作为敏化染料的光电转换装置，可以解决相关技术中的问题。在通式（1）中，R1和R2分别代表氢原子、烷基或芳基；R3至R6每个代表具有1到18个碳原子的烷基；X代表卤素原子；Y代表一价阴离子；当R3至R6每个具有1到5个碳原子时，Z代表烷基、烷氧基或芳基；当R3至R6每个具有6到18个碳原子时，Z代表氢原子、烷基、烷氧基或芳基；m和n各代表1到12的整数。

  公开号：

  EP2684872A1
• 作为产物：
  描述：

  1-甲基-5-巯基-1H-四氮唑 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 以82%的产率得到1-甲基-1H-四唑-5-硫醇钾
  参考文献：
  名称：

  COMPOUND HAVING HEPTAMETHINE STRUCTURE, SENSITIZING DYE AND PHOTOELECTRIC CONVERSION ELEMENT

  摘要：

  提供的是一种具有七甲基结构的化合物，其通式如下（1），用作光电转换装置的敏化染料，以及使用该化合物作为敏化染料的光电转换装置，可以解决相关技术中的问题。在通式（1）中，R1和R2分别代表氢原子、烷基或芳基；R3至R6每个代表具有1到18个碳原子的烷基；X代表卤素原子；Y代表一价阴离子；当R3至R6每个具有1到5个碳原子时，Z代表烷基、烷氧基或芳基；当R3至R6每个具有6到18个碳原子时，Z代表氢原子、烷基、烷氧基或芳基；m和n各代表1到12的整数。

  公开号：

  EP2684872A1

文献信息

• 3-Substituted-7-substituted alkanamido-3-cephem-4-carboxylic acid
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04254260A1

  公开（公告）日：1981-03-03

  3-Substituted-7-substituted alkanamido-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antimicrobial activities, processes for the preparation thereof, pharmaceutical compositions comprising the same, and methods of using the same therapeutically in the treatment of infections.

  3-取代-7-取代烷基氨基-3-头孢烯-4-羧酸化合物及其具有抗微生物活性的药用盐，其制备方法，包括相同化合物的药物组合物，以及在治疗感染方面的治疗使用方法。
• Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins
  作者：Shrenik K. Shah、Karen A. Brause、Gilbert O. Chandler、Paul E. Finke、Bonnie M. Ashe、Hazel Weston、Wilson B. Knight、Alan L. Maycock、James B. Doherty

  DOI：10.1021/jm00171a030

  日期：1990.9

  Several 3'-substituted cephalosporin sulfones were synthesized from 3-(hydroxymethyl)cephalosporin, which was prepared by Ti(OiPr)4 hydrolysis of the corresponding acetate. A method was also developed to prepare a 3-vinylcephalosporin. Some of these compound were found to be potent time-dependent inhibitors of human leukocyte elastase (HLE). The HLE inhibitory activity was correlated with sigma 1 and it was concluded that the potency was determined by the electron-withdrawing ability as well as the size of the substituent. A mechanism for inhibition of HLE by cephalosporin sulfones is proposed.
• SHAH, SHRENIK K.;BRAUSE, KAREN A.;CHANDLER, GILBERT O.;FINKE, PAUL E.;ASH+, J. MED. CHEM., 33,(1990) C. 2529-2535
  作者：SHAH, SHRENIK K.、BRAUSE, KAREN A.、CHANDLER, GILBERT O.、FINKE, PAUL E.、ASH+

  DOI：——

  日期：——
• [EN] NOVEL SPECIFICALLY SUBSTITUTED THIOPHENOLIC COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS THIOPHÉNOLIQUES À SUBSTITUTION SPÉCIFIQUE
  申请人：[en]NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：WO2024028169A1

  公开（公告）日：2024-02-08

  The present invention relates to novel thiophenolic compounds (I) which are useful in the treatment of proliferative and/or hyper-proliferative diseases. Preferably, the compounds of the present invention are endowed with inhibitory activity against Werner helicase protein (WRN, RECQL2) and are thus useful in the therapy or treatment of cancer. Furthermore, the invention relates to the use of the compounds according to the invention to inhibit the activity of one or more helicases, preferably including Werner Helicase (WRN) and pharmaceutical composition comprising such compounds. Formula (I).
• COMPOUND HAVING HEPTAMETHINE STRUCTURE, SENSITIZING DYE AND PHOTOELECTRIC CONVERSION ELEMENT
  申请人：Gifu University

  公开号：EP2684872A1

  公开（公告）日：2014-01-15

  Provided is a compound having a heptamethine structure represented by the following general formula (1) used as a sensitizing dye for a photoelectric conversion device, and a photoelectric conversion device using the compound as a sensitizing dye, which may solve the problems of the related art. In the general formula (1), R1 and R2 each represent a hydrogen atom, an alkyl group or an aryl group; R3 to R6 each represent an alkyl group having from 1 to 18 carbon atoms; X represents a halogen atom; Y represents a monovalent anion; Z represents an alkyl group, an alkoxy group or an aryl group when R3 to R6 each have from 1 to 5 carbon atoms, or a hydrogen atom, an alkyl group, an alkoxy group or an aryl group when R3 to R6 each have from 6 to 18 carbon atoms; and m and n each represent an integer of from 1 to 12.

  提供的是一种具有七甲基结构的化合物，其通式如下（1），用作光电转换装置的敏化染料，以及使用该化合物作为敏化染料的光电转换装置，可以解决相关技术中的问题。在通式（1）中，R1和R2分别代表氢原子、烷基或芳基；R3至R6每个代表具有1到18个碳原子的烷基；X代表卤素原子；Y代表一价阴离子；当R3至R6每个具有1到5个碳原子时，Z代表烷基、烷氧基或芳基；当R3至R6每个具有6到18个碳原子时，Z代表氢原子、烷基、烷氧基或芳基；m和n各代表1到12的整数。