1-硝基丙-1-烯-2-胺 | 71145-07-8

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 中文名称: 1-硝基丙-1-烯-2-胺
• 英文名称: 2-amino-1-nitropropylene
• 英文别名: 1-nitroprop-1-en-2-amine；1-methyl-2-nitrovinylamine；2-Amino-1-nitro-1-propene
• CAS: 71145-07-8
• 化学式: C₃H₆N₂O₂
• 分子量: 102.093
• InChiKey: HSPVTPHRQMNTQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酰丙酮酸乙酯 、 1-硝基丙-1-烯-2-胺 在 溶剂黄146 作用下， 反应 72.0h， 以80%的产率得到2,6-dimethyl-3-nitro-4-ethoxycarbonylpyridine
  参考文献：
  名称：

  Synthesis of pyridines by cyclocondensation of acetyl and benzoyl pyruvates with enamines

  摘要：

  4-Ethoxycarbonylpyridines containing acetyl, benzoyl, cyclopropanoyl, and nitro groups at position 3 have been synthesized by the reaction of acetyl and benzoyl pyruvates with various enamines.

  DOI：

  10.1007/s10593-011-0659-6
• 作为产物：
  描述：

  1-硝基乙酮 在 ammonium acetate 作用下， 以 甲苯 为溶剂， 反应 18.0h， 生成 1-硝基丙-1-烯-2-胺
  参考文献：
  名称：

  WO2006/117368

  摘要：

  公开号：

文献信息

• [EN] SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE<br/>[FR] INHIBITEURS À PETITE MOLÉCULE DE KINASE INDUISANT NF-KB
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2020239999A1

  公开（公告）日：2020-12-03

  The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

  本发明涉及抑制NIK的化合物，以及包含这些化合物的药物组合物和使用方法。这些化合物和药物组合物预期能用于预防或治疗癌症（如包括白血病、淋巴瘤和多发性骨髓瘤的B细胞恶性肿瘤）、炎症性疾病、自身免疫疾病、免疫皮肤病学疾病（如掌跖脓疱病和化脓性汗腺炎）以及代谢紊乱疾病（如肥胖和糖尿病）。
• Circulation-active substituted 1,4-dihydropyridine-3-carboxylic acid
  申请人：Bayer Aktiengesellschaft

  公开号：US04753936A1

  公开（公告）日：1988-06-28

  1,4-Dihydropyridine-3-carboxylic acid piperazides of the formula ##STR1## in which R.sup.1 is CN or alkyl, preferably methyl, R.sup.2 is H, CN, NO.sub.2 or preferably carboxyalkyl, R.sup.3 is aryl or heterocyclic, and R.sup.4 is alkyl, cycloalkyl, aryl or an acyl radical, and physiologically acceptable salts thereof, are circulation active. Novel intermediates are also provided.

  公式为##STR1##的1,4-二氢吡啶-3-羧酸哌嗪衍生物，其中R.sup.1为CN或烷基，最好是甲基，R.sup.2为H，CN，NO.sub.2或最好是羧基烷基，R.sup.3为芳基或杂环基，R.sup.4为烷基，环烷基，芳基或酰基基团，以及其生理上可接受的盐，具有循环活性。还提供了新的中间体。
• Method of combatting coronary and vascular diseases
  申请人：Bayer Aktiengesellschaft

  公开号：US04532248A1

  公开（公告）日：1985-07-30

  1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, and R.sup.1 to R.sup.7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful in increasing the influx of Ca.sup.++ into cells, particularly in combatting coronary and vascular diseases, hypertension swelling in the mucous membranes and diseases involving increased blood sugar or an incorrect salt and fluid balance.

  公式为##STR1##的1,4-二氢吡啶，其中n为0、1或2，R.sup.1到R.sup.7可以有各种含义，具有肌力作用，其中许多是新的，有助于增加Ca.sup.++进入细胞，特别是对抗冠状动脉和血管疾病、高血压、粘膜肿胀和涉及血糖增高或不正确的盐和液体平衡的疾病。
• 4-Phenyl-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility
  申请人：Karstens Willem Frederik Johan

  公开号：US20080262033A1

  公开（公告）日：2008-10-23

  The present invention- relates to 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives having the general Formula (I) wherein the substituents are defined as in the description, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives in therapy, more specifically for the treatment of fertility disorders.

  本发明涉及具有通式（I）的2-甲基-4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物，其中取代基如描述中所定义，或其药学上可接受的盐。本发明还涉及包含所述衍生物的制药组合物，以及利用这些2-甲基-4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物治疗生育障碍的用途。
• 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility
  申请人：N.V. Organon

  公开号：US08017782B2

  公开（公告）日：2011-09-13

  The present invention relates to 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives having the general Formula (I) wherein the substituents are defined as in the description, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives in therapy, more specifically for the treatment of fertility disorders.

  本发明涉及具有一般式（I）的2-甲基-4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物，其中取代基如描述中所定义，或其药学上可接受的盐。本发明还涉及包含所述衍生物的制药组合物，以及使用这些2-甲基-4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物在治疗中的用途，更具体地用于治疗生育障碍。