10,10’-氧代双吩砒 | 58-36-6

• 物质功能分类: 催化剂及助剂 - 防老剂
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 10,10’-氧代双吩砒
• 中文别名: 防霉剂OBPA；10,10'-氧代双吩砒；OBPA防霉剂；10,10’-氧双-10H-吩恶砒；吩砒嗪氧化物；10,10'-氧双吩恶砒；防霉剂75号；:防霉剂:75号防霉剂:10,10'-氧双-10H-吩恶砒；10,10'-氧化二吩恶吡；10,10’-氧双吩恶砒；10,10"-氧代双吩噁砒
• 英文名称: 10,10,oxybisphenoxarsine
• 英文别名: 10,10'-oxy-bis(phenoxarsine)；10H,10'H-10,10'-oxy-bis-phenoxarsine；bis-phenoxarsin-10-yl oxide；Bis-phenoxarsin-10-yl-oxid；diphenoxarsin-10-yl oxide；10,10'-oxybis phenoxarsine；10,10'-Oxybisphenoxarsine；10-phenoxarsinin-10-yloxyphenoxarsinine
• CAS: 58-36-6
• 化学式: C₂₄H₁₆As₂O₃
• 分子量: 502.232
• InChiKey: VCRZAKVGPJFABU-UHFFFAOYSA-N

物化性质

• 熔点：
  180-184°C
• 沸点：
  232.5°C
• 密度：
  1.40-1.42
• 物理描述：
  Phenoxarsine, 10,10'-oxydi- appears as a clear light yellow liquid with a mild odor. Insoluble in water and slightly denser than water. Contact may severely irritate skin, eyes, and mucous membranes.
• 颜色/状态：
  Colorless monoclinic prisms
• 气味：
  Odorless
• 溶解度：
  In water, 5 mg/L at 20 °C
• 蒸汽压力：
  5.1X10-12 mm Hg at 25 °C (est)
• 分解：
  When heated to decomposition it emits toxic fumes of /arsenic/.

计算性质

• 辛醇/水分配系数(LogP)：
  6.44
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

砒霜主要通过吸入或摄入被吸收，较少程度上通过皮肤接触。然后它被分布到全身，如果需要，它会被还原成亚砷酸盐，然后通过亚砷酸盐甲基转移酶甲基化成单甲基砷（MMA）和二甲基硅酸（DMA）。砒霜及其代谢物主要通过尿液排出。已知砒霜能诱导金属结合蛋白金属硫蛋白，通过绑定砒霜和其他金属并使其生物活性失效，以及作为抗氧化剂的作用，从而减少砒霜和其他金属的有毒效果。

Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

砒霜及其代谢物通过多种机制干扰ATP的产生。在柠檬酸循环层面，砒霜抑制了丙酮酸脱氢酶，并通过与磷酸竞争解耦了氧化磷酸化，从而抑制了与能量相关的NAD+还原、线粒体呼吸和ATP合成。过氧化氢的产生也增加了，这可能会形成活性氧物种和氧化应激。砒霜的致癌性受到砒霜与微管蛋白结合的影响，导致非整倍体、多倍体和有丝分裂停滞。其他砒霜蛋白靶点的结合也可能导致DNA修复酶活性改变、DNA甲基化模式改变和细胞增殖。

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

3, 其对人类致癌性无法分类。

3, not classifiable as to its carcinogenicity to humans. (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

砒霜中毒可能导致多系统器官衰竭死亡，可能是由于细胞坏死而非凋亡。砒霜也是一种已知的致癌物，尤其是在皮肤癌、肝癌、膀胱癌和肺癌中。

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L2）；吸入（L2）；皮肤（L2）

Oral (L2) ; inhalation (L2) ; dermal (L2)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

暴露于较低水平的砷可以导致恶心和呕吐，减少红白细胞的生产，心律异常，血管损伤，以及一种感觉。

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• 危险等级：
  6.1(a)
• 危险品运输编号：
  1557
• 包装等级：
  II
• 危险类别：
  6.1(a)
• 储存条件：
  2-8℃

制备方法与用途

用途

工业防霉剂不仅能有效防霉和抗菌，还能抑制藻类生长，是工业领域中高效的抗菌剂之一。它广泛应用于PVC制品、塑料制品、PVC地板材料、墙面涂料、油漆、油墨以及纸张等多种产品中。

反应信息

• 作为反应物：
  描述：

  10,10’-氧代双吩砒 在 乙醇 、 碘 作用下， 生成 10-羟基-10H-吩噁砒 10-氧化物
  参考文献：
  名称：

  Rasuwajew; Malinowski, Chemische Berichte, 1931, vol. 64, p. 120,129, 130

  摘要：

  DOI：
• 作为产物：
  描述：

  10-氯-10H-吩噁砒 在 乙醇 作用下， 以 乙醚 、 甲苯 为溶剂， 生成 10,10’-氧代双吩砒
  参考文献：
  名称：

  Gavrilov,V.I. et al., Journal of general chemistry of the USSR, 1972, vol. 42, p. 1957 - 1959

  摘要：

  DOI：

文献信息

• Amusement articles possessing microbe-inhibiting properties
  申请人：——

  公开号：US20010027755A1

  公开（公告）日：2001-10-11

  An amusement article for a domestic animal comprising an outer textile casing defining a shape in the form of a small article which can be carried by a domestic animal, an inner filling, and a microbe-inhibiting agent or property applied to at least one of the outer textile casing and the inner filling. The toys may be fabricated in various shapes, designs and styles, e.g., animals, bones, hearts, geometric shapes, etc. A process for applying the microbe-inhibiting agent or property to at least one of the outer textile casing and the inner filling is provided. Application methods include spraying, dipping, brushing, and rolling the microbe-inhibiting agent or property onto at least one of the outer textile casing and the inner filling.

  一种用于家庭宠物的娱乐用品，包括一个外部纺织外壳，定义成小型物品的形状，可以被家庭宠物携带，一个内部填充物，以及应用于至少外部纺织外壳和内部填充物之一的微生物抑制剂或性质。这些玩具可以制成各种形状、设计和风格，例如动物、骨头、心形、几何形状等。提供了一种将微生物抑制剂或性质应用于至少外部纺织外壳和内部填充物之一的过程。应用方法包括将微生物抑制剂或性质喷洒、浸泡、刷涂或滚涂至至少外部纺织外壳和内部填充物之一。
• Bedding articles possessing microbe-inhibiting properties
  申请人：Seefar Technologies, Inc.

  公开号：US06196156B1

  公开（公告）日：2001-03-06

  A bedding article for a domestic animal comprising an outer textile casing defining a geometric shape for supporting a domestic animal, an inner filling, and a microbe-inhibiting agent or property applied to at least one of the outer textile casing and the inner filling. The bedding article may be fabricated in various shapes, designs, and styles; e.g., rectangular, circular, elliptical, with or without upstanding side walls, etc. A process for applying the microbe-inhibiting agent or property to at least one on the outer textile casing and the inner filling is provided. Application methods include spraying, dipping, brushing, and rolling the microbe-inhibiting agent or property onto at least one of the outer textile casing and the inner filling. An alternative embodiment includes an outer textile casing defining a geometric shape for supporting a domestic animal, an inner filling, a lining therebetween, and a microbe-inhibiting agent or property applied to at least one of the outer textile casing, the inner lining, and the inner filling.

  一种用于家畜的寝具，包括一个外部纺织袋，定义了一个几何形状，用于支撑家畜，一个内部填充物，以及应用于外部纺织袋和内部填充物中至少一个的微生物抑制剂或性质。该寝具可以制作成各种形状、设计和风格，例如矩形、圆形、椭圆形，有或没有竖立的侧壁等。提供了一种将微生物抑制剂或性质应用于外部纺织袋和内部填充物中至少一个的方法。应用方法包括将微生物抑制剂或性质喷洒、浸泡、刷涂和滚涂到外部纺织袋和内部填充物中至少一个。另一种实施方式包括一个外部纺织袋，定义了一个几何形状，用于支撑家畜，一个内部填充物，一个内衬之间，以及应用于外部纺织袋、内部内衬和内部填充物中至少一个的微生物抑制剂或性质。
• AMUSEMENT ARTICLES POSSESSING MICROBE-INHIBITING PROPERTIES
  申请人：Denesuk Matthew

  公开号：US20070044729A1

  公开（公告）日：2007-03-01

  An amusement article for a domestic animal comprising an outer textile casing defining a shape in the form of a small article which can be carried by a domestic animal, an inner filling, and a microbe-inhibiting agent or property applied to at least one of the outer textile casing and the inner filling. The toys may be fabricated in various shapes, designs and styles, e.g., animals, bones, hearts, geometric shapes, etc. A process for applying the microbe-inhibiting agent or property to at least one of the outer textile casing and the inner filling is provided. Application methods include spraying, dipping, brushing, and rolling the microbe-inhibiting agent or property onto at least one of the outer textile casing and the inner filling.

  一种用于家养动物的娱乐用品，包括一个外部纺织物外壳，定义成小物品的形状，可以被家养动物携带，一个内部填充物，以及应用于至少一个外部纺织物外壳和内部填充物中的微生物抑制剂或性质。这些玩具可以制成各种形状，设计和样式，例如动物、骨头、心形、几何形状等。提供了一种将微生物抑制剂或性质应用于至少一个外部纺织物外壳和内部填充物的方法。应用方法包括将微生物抑制剂或性质喷洒、浸泡、刷涂或滚涂到至少一个外部纺织物外壳和内部填充物上。
• Gavrilov,V.I. et al., Journal of general chemistry of the USSR, 1974, vol. 44, p. 2465 - 2467
  作者：Gavrilov,V.I. et al.

  DOI：——

  日期：——
• Shvezova-Shilovskaya,K.D. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 776 - 780
  作者：Shvezova-Shilovskaya,K.D. et al.

  DOI：——

  日期：——