Design and synthesis of C modified and ring-truncated canthin-6-one analogues as effective membrane-active antibacterial agents
作者:Jiangkun Dai、Wenjia Dan、Yunyun Zhang、Mengfan He、Junru Wang
DOI:10.1016/j.bmcl.2018.06.001
日期:2018.10
canthin-6-one analogues were designed and synthesized in order to study their antibacterialactivity and structure–activity relationships. Compound 22 showed a broad spectrum of antibacterialactivity and exhibited better bactericidal effect (8-fold superiorityagainstStaphylococcusaureus and 2-fold superiorityagainst Ralstonia solanacearum) than fosfomycin sodium and propineb with a minimum inhibitory