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11-甲基-20,21-二去甲埃那美宁 | 123829-33-4

中文名称
11-甲基-20,21-二去甲埃那美宁
中文别名
1-(5-乙基-1,3,4-噻二唑-2-基)-3-苯基-吡咯烷-2,5-二酮
英文名称
11-Methyl-20,21-dinoreburnamenine
英文别名
(15R,19S)-4-methyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2(7),3,5,8(18),16-pentaene
11-甲基-20,21-二去甲埃那美宁化学式
CAS
123829-33-4;123828-80-8
化学式
C18H20N2
mdl
——
分子量
264.4
InChiKey
WPVRIAJLUFENAH-DYVFJYSZSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.2
  • 重原子数:
    20
  • 可旋转键数:
    0
  • 环数:
    5.0
  • sp3杂化的碳原子比例:
    0.44
  • 拓扑面积:
    8.2
  • 氢给体数:
    0
  • 氢受体数:
    1

文献信息

  • [EN] ARYL IMIDAZOLE COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS<br/>[FR] COMPOSÉ ARYLIMIDAZOLE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PRODUCTION DE LA PROTÉINE AMYLOÏDE BÊTA
    申请人:EISAI R&D MAN CO LTD
    公开号:WO2010098488A1
    公开(公告)日:2010-09-02
    A compound represented by the formula (I): or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a triazolyl group or the like which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.
    一种由化学式(I)表示的化合物,或其药理学上可接受的盐或酯,其中环A代表可能被取代的三唑基团或类似物,环B代表可能被取代的苯基团或类似物,X1代表单键或类似物,R1和R2分别代表C1-6烷基或类似物,m代表0到3的整数,n代表0到2的整数,对于由Aβ引起的疾病具有治疗作用。
  • MULTI-CYCLIC COMPOUNDS
    申请人:KIMURA Teiji
    公开号:US20090062529A1
    公开(公告)日:2009-03-05
    A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar 1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar 2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X 1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
    一种由化学式(I)表示的化合物或其药理学可接受的盐,其中Ar1代表可用C1-6烷基基团取代的咪唑基团或类似基团,Ar2代表可用C1-6烷氧基团取代的苯基团或类似基团,X1代表双键或类似基团,Het代表可用C1-6烷基基团或类似基团取代的三唑基团或类似基团,对由Aβ引起的疾病具有治疗或预防作用。
  • [EN] NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES CONDENSÉS CONTENANT DE L'AZOTE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PRODUCTION DE LA BÊTA-AMYLOÏDE
    申请人:EISAI R&D MAN CO LTD
    公开号:WO2010098487A1
    公开(公告)日:2010-09-02
    A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.
    化合物的分子式为[I]:或其药理学可接受的盐或酯,其中环A代表一个五元芳香杂环基团或类似于非芳香环基团的融合物,可以被取代,环B代表一个苯基或类似的基团,可以被取代,X1代表一个单键或类似物,R1和R2分别代表一个C1-6烷基基团或类似物,m表示0到3的整数,n表示0到2的整数,对由Aβ引起的疾病具有治疗作用。
  • [EN] IMIDAZOLYLPYRAZINE DERIVATIVES<br/>[FR] DÉRIVÉS D'IMIDAZOLYLPYRAZINE
    申请人:EISAI R&D MAN CO LTD
    公开号:WO2010098495A1
    公开(公告)日:2010-09-02
    To provide a novel low-molecular-weight compound that inhibits the production of amyloid-β (Aβ ). A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein R1 and R2 are the same or different and each represent a substituent selected from the following Substituent Group a1; m represents an integer of 0 to 3; n represents an integer of 0 to 2; X1 represents a single bond or the like; X2 represents a single bond or the like; Ring A represents a five-membered aromatic heterocyclic group or the like which contains two or more nitrogen atoms and may have 1 to 3 substituents selected from the following Substituent Group b1; and Ring B represents a monocyclic or fused cyclic aromatic ring group such as the formula [2] which may have 1 to 3 substituents selected from the following Substituent Group c1, is effective as a therapeutic agent for a disease such as Alzheimer's disease. Substituent Group a1: a C1-6 alkyl group and the like Substituent Group b1: a C1-6 alkyl group and the like Substituent Group c1: an amino group and the like
    提供一种新型低分子量化合物,该化合物能够抑制淀粉样蛋白-β(Aβ)的产生。表示为化学式[I]的化合物,或其药理学上可接受的盐或酯,其中R1和R2相同或不同,每个代表以下取代基团a1中选择的取代基;m代表0到3的整数;n代表0到2的整数;X1代表单键或类似物;X2代表单键或类似物;环A代表含有两个或更多氮原子并且可能具有1到3个取代基团b1中选择的取代基的五元芳香杂环基团或类似物;环B代表可能具有1到3个取代基团c1中选择的取代基的单环或融合环芳香环基团,如化学式[2]所示,对于阿尔茨海默病等疾病具有治疗作用。取代基团a1:C1-6烷基基团等;取代基团b1:C1-6烷基基团等;取代基团c1:基团等。
  • Nitrogen-Containing Fused Heterocyclic Compounds and Their use as Beta Amyloid Production Inhibitors
    申请人:Kitazawa Noritaka
    公开号:US20120053171A1
    公开(公告)日:2012-03-01
    A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.
    化合物的化学式为[I],或其药理学上可接受的盐或酯,其中环A代表一个五元芳香杂环基团或类似物,与非芳香环基团融合,可以被取代,环B代表苯基或类似物,可以被取代,X1代表单键或类似物,R1和R2各代表C1-6烷基或类似物,m代表0至3的整数,n代表0至2的整数,该化合物对由Aβ引起的疾病具有治疗作用。
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