温可纳特

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吲哚萘啶生物碱
• 中文名称: 温可纳特
• 英文名称: hydron;methyl 6-ethyl-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-2,9(16),10,12,14-pentaene-2-carboxylate;chloride
• 化学式: C18H21ClN2O2
• 分子量: 332.8
• InChiKey: UVPBAANTIASPBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  34.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• DRUG COMPOUNDING INGREDIENTS COMPRISING N-SUBSTITUTED-O-TOLUIDINE DERIVATIVE AND PERCUTANEOUSLY ABSORBABLE PREPARATION
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP0782861A1

  公开（公告）日：1997-07-09

  A drug resolvent and a drug sorbefacient each comprising at least one N-substituted-o-toluidine derivative represented by general formula (I), and a percutaneously absorbable preparation containing a drug and the resolvent or the sorbefacient, wherein R1 represents C1-C4 alkyl; and R2 represents C1-C8 alkyl.

  一种药物溶解剂和一种药物吸附剂，各自包含至少一种由通式（I）代表的 N-取代-邻甲基苯胺衍生物，以及一种含有药物和溶解剂或吸附剂的经皮吸收制剂，其中 R1 代表 C1-C4 烷基；R2 代表 C1-C8 烷基。
• SHEET-FORM ADHESIVE PREPARATION
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1151749A1

  公开（公告）日：2001-11-07

  A sheet-form adhesive preparation which gives a comfortable refreshing feeling in use, gives a wet feeling to the skin, and is usable a a cosmetic, medicinal, or quasi-drug preparation for the sake of skin adjustment and beauty. The preparation preferably has a quantity of heat required for water evaporation of 0.6 to 13 (cal) per unit area (cm2) when exposed for 30 minutes to an atmosphere of 25°C and 60% Rh.

  一种片状粘合剂制剂，在使用时给人一种舒适清爽的感觉，给皮肤一种湿润的感觉，可用作化妆品、药物或准药物制剂，用于调整皮肤和美容。当该制剂暴露在 25°C 和 60% Rh 的环境中 30 分钟时，水蒸发所需的热量最好为每单位面积（cm2）0.6 至 13（卡）。
• Sheet-like patch agent
  申请人：——

  公开号：US20040156886A1

  公开（公告）日：2004-08-12

  A sheet-like patch agent, comprising a support body and an adhesive agent layer, characterized in that a tension shear adhesive strength obtained when the adhesive agent surface is overlappingly adhered on the support body surface is 0.015 to 0.07 kgf/cm 2 (0.00147 to 0.00686 N/mm 2 ), whereby the sheet-like patch agent safe for skin, excellent in use feeling, and excellent in working effect in addition to cooling action to affected areas, and preventing an overlapped portion from being curled up and peeled off immediately even when taped on a finger, a wrist, an ankle, a neck, an elbow, and a knee.

  一种片状修补剂，包括支撑体和粘合剂层，其特征在于，当粘合剂表面重叠粘合在支撑体表面时，获得的拉伸剪切粘合强度为 0.015 至 0.07 kgf/cm 2 （0.00147 至 0.00686 牛顿/毫米 2 )，因此片状贴剂对皮肤安全，使用感极佳，除对患处有降温作用外，还具有极佳的工作效果，即使贴在手指、手腕、脚踝、颈部、肘部和膝盖上，也能防止重叠部分卷曲并立即剥离。
• Patch
  申请人：Muta Kazunori

  公开号：US20060030801A1

  公开（公告）日：2006-02-09

  A patch comprising a backing layer and a adhesive layer formed on the back face of the backing layer wherein a woven fabric or a nonwoven fabric made of a rayon and pulp fiber mixture is employed as the backing layer and the mixing ratio thereof is from 3:7 to 7:3. When employed in taping a finger, a wrist, an ankle, neck, an elbow, a knee or the like, the patch would not soon curl up or peel off at an overlapping part. After the patch is adhered and then stripped off, no fiber piece remains on the pressure-sensitive adhesive face of the backing layer so that the adhesive force of the patch can be sustained in the case of re-adhesion.

  一种贴布，包括背衬层和形成于背衬层背面的粘合层，其中背衬层采用人造丝和纸浆纤维混合物制成的编织物或无纺布，其混合比例为 3:7 至 7:3。当用于粘贴手指、手腕、脚踝、颈部、肘部、膝盖或类似部位时，贴片不会很快在重叠部分卷曲或脱落。贴片粘贴后再剥离时，背衬层的压敏粘合面上不会残留纤维片，因此在再次粘贴时，贴片的粘合力可以持续。
• Sheet-type patch
  申请人：Kose Yasuhisa

  公开号：US20050181163A1

  公开（公告）日：2005-08-18

  It is intended to provide a sheet-type patch which is safe to the skin, imparts a good feel in using, shows an excellent function as well as a cooling effect on the affected part, can be easily torn by hand into a desired size even in the state of a preparation provided with a release film bonded thereto, and can be stably used or stored after tearing. Namely, a sheet-type patch composed of a support made from yarns of 1 to 80 mm in fiber length, an ointment base and a release film having been punched so as to give pores of 10 to 1200 μm in size.