1H-吲哚-7-磺酰胺 | 111048-64-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 1H-吲哚-7-磺酰胺
• 英文名称: 1H-indole-7-sulfonamide
• CAS: 111048-64-7
• 化学式: C₈H₈N₂O₂S
• 分子量: 196.23
• InChiKey: OZEDQORHGRJQAF-UHFFFAOYSA-N

物化性质

• 沸点：
  474.8±37.0 °C(Predicted)
• 密度：
  1.500±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-二氯苯甲酸 、 1H-吲哚-7-磺酰胺 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 2,4-dichloro-N-(1H-indol-7-ylsulfonyl)benzamide
  参考文献：
  名称：

  Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

  摘要：

  The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.041
• 作为产物：
  描述：

  7-溴吲哚 在 ammonium hydroxide 作用下， 以 丙酮 为溶剂， 生成 1H-吲哚-7-磺酰胺
  参考文献：
  名称：

  Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

  摘要：

  The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.041

文献信息

• [EN] 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10<br/>[FR] ANTAGONISTES DE 2-SULFONYLAMINO-4-HÉTÉROARYL BUTYRAMIDE DE CCR10
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009126675A1

  公开（公告）日：2009-10-15

  This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.

  本发明涉及一种具有式（I）的化合物及其药学上可接受的盐，其中R1、R2、R4、Ar和Het如本文中所定义。该发明还涉及使用式（I）的化合物治疗通过CCR10活性介导或维持的疾病和紊乱的方法。
• Herbicidal sulfonamides
  申请人：E. I. Du Pont de Nemours and Comany

  公开号：US04683000A1

  公开（公告）日：1987-07-28

  Novel N-(heterocyclicaminocarbonyl)arylsulfonamides such as 2,3-dihydro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-1H-in dole-7-sulfonamide are useful as pre-emergence and post-emergence herbicides and for the regulation of plant growth.

  新型N-(杂环氨基甲酰)芳基磺酰胺，例如2,3-二氢-N-[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基甲酰]-1H-吲哚-7-磺酰胺，可用作前期和后期除草剂，并用于植物生长的调节。
• [EN] INDOL-7 SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE 5-HT-6 AS MODULATORS<br/>[FR] DERIVES D'INDOL-7-YL SULFONAMIDE, FABRICATION ET UTILISATION EN TANT QUE MODULATEURS DE 5-HT-6
  申请人：ESTEVE LABOR DR

  公开号：WO2005013979A1

  公开（公告）日：2005-02-17

  The present invention refers to new sulfonamide derivatives, of general formula (la, lb, ic), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.

  本发明涉及新的磺酰胺衍生物，其通式为（la，lb，ic），可选地为它们的立体异构体之一，优选为对映异构体或非对映异构体，它们的消旋体，或者以任何混合比例形式的至少两种立体异构体的混合物，优选为对映异构体或非对映异构体，它们的盐，优选为相应的生理上可接受的盐，或相应的溶剂化物；以及它们的制备方法，它们在人类和/或兽医治疗中作为药物的应用，以及包含它们的制药组合物。
• Organic Compounds and Their Uses
  申请人：Brandl Trixi

  公开号：US20080045530A1

  公开（公告）日：2008-02-21

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

  本申请描述了有机化合物，可用于治疗、预防和/或改善人类疾病。
• Indol-7 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators
  申请人：Merce Vidal Ramon

  公开号：US20070185207A1

  公开（公告）日：2007-08-09

  The present invention refers to new sulfonamide derivatives, of general formula (1a, 1b, ic), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.

  本发明涉及新的磺酰胺衍生物，一般式为（1a，1b，ic），可以是它们的立体异构体之一，优选是对映异构体或二对映异构体，它们的外消旋体，或者以任何混合比例的至少两种立体异构体，优选是对映异构体或二对映异构体的混合物，或它们的盐，优选是相应的生理上可接受的盐，或相应的溶剂化物；以及它们的制备方法，作为人类和/或兽医治疗药物的应用，以及含有它们的制药组合物。