2'-脱氧-7,8-二氢-8-氧代腺苷 | 62471-63-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 中文名称: 2'-脱氧-7,8-二氢-8-氧代腺苷
• 英文名称: 2'-Deoxy-7,8-dihydro-8-oxoadenosine
• 英文别名: 6-amino-9-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7H-purin-8-one
• CAS: 62471-63-0
• 化学式: C₁₀H₁₃N₅O₄
• 分子量: 267.24
• InChiKey: NDWAUKFSFFRGLF-YRZWDFBDSA-N

物化性质

• 密度：
  1.672±0.06 g/cm3(Predicted)
• 溶解度：
  少许溶于甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] MITOCHONDRIAL APOPTOSIS-INDUCED INFLAMMATION<br/>[FR] INFLAMMATION INDUITE PAR L'APOPTOSE MITOCHONDRIALE
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2012016145A2

  公开（公告）日：2012-02-02

  Disclosed is a method of treating inflammation, an inflammatory disease, an inflammatory disease condition and/or an autoimmune disease in a subject in need thereof. The method can comprise providing a composition comprising a mitochondrial apoptosis inhibitor or an oxidative nucleotide and administering the composition to the subject to treat the inflammation, the inflammatory disease, the inflammatory disease condition and/or the autoimmune disease. Said method is based on the mitochondria actingg as a unifying point that integrates diverse NLRP3 stimuli and that mitochondrial dysfunction and apoptosis of macrophages are critical steps in various danger signal-induced NLRP3 inflammasome activation.