2,2,3,3-四氟丙基二氟甲醚 | 35042-99-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,2,3,3-四氟丙基二氟甲醚
• 中文别名: 二氟甲基2,2,3,3-四氟丙基醚
• 英文名称: 2,2,3,3-tetrafluoropropyl difluoromethyl ether
• 英文别名: 2,2,3,3-tetrafluoro-1-difluoromethoxypropane；3-difluoromethoxy-1,1,2,2-tetrafluoropropane；2,2,3,3-Tetrafluorpropyl-difluormethylether；Difluormethyl-2,2,3,3-tetrafluorpropylether；Difluoromethyl 2,2,3,3-tetrafluoropropyl ether；3-(difluoromethoxy)-1,1,2,2-tetrafluoropropane
• CAS: 35042-99-0
• 化学式: C₄H₄F₆O
• mdl: MFCD00236119
• 分子量: 182.066
• InChiKey: PCTQNZRJAGLDPD-UHFFFAOYSA-N

物化性质

• 沸点：
  69 °C
• 密度：
  1.47
• 稳定性/保质期：
  常规情况下不会分解，也没有危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  7

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 危险类别码：
  R10,R36/37/38
• 危险品运输编号：
  3271
• 安全说明：
  S16,S26,S36/37/39
• 储存条件：
  在2°C至-10°C下保存

反应信息

• 作为产物：
  描述：

  氟里昂-22 、 四氟丙醇 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以55%的产率得到2,2,3,3-四氟丙基二氟甲醚
  参考文献：
  名称：

  Reactions of aliphatic fluoro-alcohols with CHClF2 at atmospheric pressure

  摘要：

  The reactions of aliphatic fluoro-alcohols with chlorodifluoromethane (CHCIF2) at atmospheric pressure were examined. In the reaction of CF3CF2CH2OH, the difluoromethylated ether was obtained in moderate yield by using ethers such as 1,4-dioxane, diglyme and THF, or their mixtures with water as a reaction solvent. While acetal and orthoformate were also produced, the selectivity of the difluoromethylated ether could be improved by adding water to the reaction. The effect of water could be explained by the reaction mechanism. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2005.12.034

文献信息

• A simple convenient method for preparation of difluoromethyl ethers using fluorosulfonyldifluoroacetic acid as a difluorocarbene precursor
  作者：Qing-Yun Chen、Sheng-Wen Wu

  DOI：10.1016/s0022-1139(00)82808-0

  日期：1989.9

  In the presence of catalytic amounts of sodium sulfate or cuprous iodide, a variety of alkyl and aryl difluoromethyl ethers were synthesized in moderate yields by the reaction of the corresponding alcohols and phenols with fluorosulfonyldifluoroacetic acid (1) in acetonitrile under mild conditions. Fluorosulfonyldifluoroacetate anion [FO2SCF2OC2-] (5) is believed to readily eliminate SO2, CO2 and F-

  在催化量的硫酸钠或碘化亚铜的存在下，通过使相应的醇和酚与氟磺酰基二氟乙酸（1）在乙腈中，温和的条件下反应，以中等收率合成了各种烷基和芳基二氟甲基醚。Fluorosulfonyldifluoroacetate阴离子[FO 2 SCF 2 OC 2 - ]（5）被认为是容易消除SO 2，CO 2和F - ，从而解放CF 2：; 然后二氟卡宾的插入OH键和由氟离子它的捕获导致醚的形成和副产物CF 3分别H，。
• CHEN, QING-YUN;WU, SHENG-WEN, J. FLUOR. CHEM., 44,(1989) N, C. 433-440
  作者：CHEN, QING-YUN、WU, SHENG-WEN

  DOI：——

  日期：——
• CHEN, QINGYUN;ZHU, SHIZENG, ORG. CHEM., 1984, N 6, 434-439
  作者：CHEN, QINGYUN、ZHU, SHIZENG

  DOI：——

  日期：——
• Reactions of aliphatic fluoro-alcohols with CHClF2 at atmospheric pressure
  作者：Junji Mizukado、Yasuhisa Matsukawa、Heng-dao Quan、Masanori Tamura、Akira Sekiya

  DOI：10.1016/j.jfluchem.2005.12.034

  日期：2006.3

  The reactions of aliphatic fluoro-alcohols with chlorodifluoromethane (CHCIF2) at atmospheric pressure were examined. In the reaction of CF3CF2CH2OH, the difluoromethylated ether was obtained in moderate yield by using ethers such as 1,4-dioxane, diglyme and THF, or their mixtures with water as a reaction solvent. While acetal and orthoformate were also produced, the selectivity of the difluoromethylated ether could be improved by adding water to the reaction. The effect of water could be explained by the reaction mechanism. (c) 2006 Elsevier B.V. All rights reserved.