2,2-双(4-氯苯基)乙胺 | 85336-82-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,2-双(4-氯苯基)乙胺
• 英文名称: 2,2-bis(4-chlorophenyl)ethanamine
• 英文别名: 2,2-bis(4-chlorophenyl)ethan-1-amine；2,2-di(4-chlorophenyl)ethylamine；2,2-bis-(4-chloro-phenyl)-ethylamine；2,2-Bis-(4-chlor-phenyl)-aethylamin；2.2-Bis-(4-chloro-phenyl)-ethylamine；2,2-bis(4-chlorophenyl)ethylamine
• CAS: 85336-82-9
• 化学式: C₁₄H₁₃Cl₂N
• 分子量: 266.17
• InChiKey: KDDFOSJQPZKUJZ-UHFFFAOYSA-N

物化性质

• 沸点：
  158-162 °C(Press: 1.2 Torr)
• 密度：
  1.245±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2-双(4-氯苯基)乙胺 在 二(三叔丁基膦)钯 potassium carbonate 作用下， 以 various solvent(s) 为溶剂， 反应 30.0h， 生成 (S)-2-(4-chloro-phenyl)-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethylamine
  参考文献：
  名称：

  Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

  摘要：

  Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 microM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand efficient analogues using a fragment growing approach. Iterative structure-based design was supported by protein-ligand structure determinations using a PKA-PKB "chimera" and a final protein-ligand structure of a lead compound in PKBbeta itself.

  DOI：

  10.1021/jm070091b
• 作为产物：
  描述：

  (E)-2,2-bis(4-chlorophenyl)-N-methoxyethanimine 在 diborane(6) 、 sodium hydroxide 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 2,2-双(4-氯苯基)乙胺
  参考文献：
  名称：

  [EN] 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS
  [FR] NOUVEAUX DERIVES 2-AMINO BENZIMIDAZOLE ET UTILISATION DE CEUX-CI COMME MODULATEURS DES CANAUX DE POTASSIUM ACTIVES PAR CALCIUM A FAIBLE CONDUCTANCE

  摘要：

  公开号：

  WO2006013210A3

文献信息

• Purine derivatives
  申请人：——

  公开号：US20020032168A1

  公开（公告）日：2002-03-14

  The present invention relates to compounds of the formula 1 and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as adenosine A2a receptor agonists.

  本发明涉及具有公式1的化合物，以及药用可接受的盐和溶剂化物，还涉及用于制备这些化合物的过程、在制备中使用的中间体，以及包含这些化合物的组合物，以及这些化合物作为腺苷A2a受体激动剂的使用。
• Direct Access to Primary Amines from Alkenes by Selective Metal‐Free Hydroamination
  作者：Yi‐Dan Du、Bi‐Hong Chen、Wei Shu

  DOI：10.1002/anie.202016679

  日期：2021.4.26

  selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal‐free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α‐branched, and α‐tertiary

  由容易获得的前体直接和选择性合成伯胺是有吸引力的，但仍具有挑战性。在此，我们报道了室温下通过无金属的区域选择性加氢胺从烯烃快速合成伯胺的方法。碳酸铵首次用作氨替代物，可在温和条件下将末端和内部烯烃有效转化为线性，α支化和α叔伯胺。该方法提供了一种直接而有效的方法，可用于制药化学和其他领域特别感兴趣的各种先进的，高度官能化的伯胺。
• Sulfonamide compounds
  申请人：Allison Brett

  公开号：US20060069286A1

  公开（公告）日：2006-03-30

  Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.

  某些磺酰胺化合物是双CCK1/CCK2抑制剂，在治疗CCK1/CCK2介导的疾病中很有用。
• [EN] PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS<br/>[FR] DERIVES DE PYRAZOLE SERVANT DE MODULATEURS DE PROTEINE KINASE
  申请人：ASTEX TECHNOLOGY LTD

  公开号：WO2005061463A1

  公开（公告）日：2005-07-07

  The invention provides compounds of the formula: (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between Rl and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the inker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom a with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; Rl is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, methods for preparing the compounds and their use as anticancer agents.

  该发明提供了具有蛋白激酶B抑制活性的化合物，其化学式为：（I），其中A是一个饱和的含有1至7个碳原子的烷基链连接基团，该连接基团在R1和NR2R3之间延伸的最大链长为5个原子，在E和NR2R3之间延伸的最大链长为4个原子，其中连接基团中的一个碳原子可以选择性地被氧原子或氮原子取代；连接基团A的碳原子可以选择性地携带来自酮基、氟和羟基的一个或多个取代基，前提是当存在羟基时，该羟基不位于相对于NR2R3基团的碳原子a处，且当存在酮基时，该酮基位于相对于NR2R3基团的碳原子a处；E是一个单环或双环的碳环或杂环基团；R1是芳基或杂芳基团；R2、R3、R4和R5如权利要求中所定义。还提供了含有这些化合物的药物组合物，制备这些化合物的方法以及它们作为抗癌剂的用途。
• PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS
  申请人：Thompson Neil Thomas

  公开号：US20100166699A1

  公开（公告）日：2010-07-01

  The invention provides a combination comprising an ancillary compound (e.g. one, two or more ancillary compounds) and a compound of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R 1 and NR 2 R 3 and a maximum chain length of 4 atoms extending between E and NR 2 R 3 , wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the NR 2 R 3 group and provided that the oxo group when present is located at a carbon atom a with respect to the NR 2 R 3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R is an aryl or heteroaryl group; and R 2 , R 3 , R 4 and R 5 are as defined in the claims. Also provided are patient packs, pharmaceutical kits and packs and compositions containing the combinations, methods for preparing the combinations and their use in combination therapy as anticancer agents.

  该发明提供了一种组合物，包括一个辅助化合物（例如一个、两个或更多个辅助化合物）和具有蛋白激酶B抑制活性的式（I）化合物：其中A是含有1至7个碳原子的饱和碳氢链连接基团，连接基团在R1和NR2R3之间延伸的最大链长为5个原子，在E和NR2R3之间延伸的最大链长为4个原子，其中连接基团中的一个碳原子可以选择性地被氧原子或氮原子取代；连接基团A的碳原子可以选择性地携带来自酮基、氟和羟基的一个或多个取代基，前提是当羟基存在时，不位于相对于NR2R3基团的碳原子a处，且当酮基存在时，位于相对于NR2R3基团的碳原子a处；E是单环或双环碳环或杂环基团；R是芳基或杂芳基团；R2、R3、R4和R5如权利要求中所定义。还提供了患者包装、药物配套和包装以及含有这些组合物的组合物、制备这些组合物的方法以及它们作为抗癌剂的联合治疗中的用途。