2,3,4-三氯喹啉 | 40335-02-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2,3,4-三氯喹啉
• 中文别名: 咪喹莫得杂质和衍生物；2,3,4-三氯甲基喹啉
• 英文名称: 2,3,4-trichloroquinoline
• 英文别名: 2,3,4-trichloro-quinoline；2,3,4-Trichlor-chinolin；2,3,4-Trichlorquinoline；2,3,4-Trichlorchinolin
• CAS: 40335-02-2
• 化学式: C₉H₄Cl₃N
• mdl: MFCD00209478
• 分子量: 232.496
• InChiKey: OVAXVANZWJUQBI-UHFFFAOYSA-N

物化性质

• 沸点：
  308.4±37.0 °C(Predicted)
• 密度：
  1.523±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3,4-三氯喹啉 在 氢氧化钾 、 potassium permanganate 作用下， 生成 4,5,6-Trichlochinolinsaeure
  参考文献：
  名称：

  Koegl et al., Recueil des Travaux Chimiques des Pays-Bas, 1948, vol. 67, p. 29,37

  摘要：

  DOI：
• 作为产物：
  描述：

  3-苯胺基-3-羰基丙酸 在 五氯化磷 、 苯 作用下， 生成 2,3,4-三氯喹啉
  参考文献：
  名称：

  Ruegheimer, Chemische Berichte, 1884, vol. 17, p. 737

  摘要：

  DOI：

文献信息

• Synthesis of quinolin-4-yl substituted malonates, cyanoacetates, acetoacetates and related compounds
  作者：Wolfgang Stadlbauer、Anna E. Täubl、Hoai V. Dang、Claudia Reidlinger、Klaus Zangger

  DOI：10.1002/jhet.5570430118

  日期：2006.1

  CH-acidic compounds such as malonates 2a,b, ethyl cyanoacetate (2c), malononitrile (2d), ethyl acetoacetate (2e), acetylacetone (2f) or dimedone (2g) under mild conditions and good yields to quinolin-4-yl substituted derivatives 3-8 and 11. With 3-phenylsulfonylquinolones 1i-k a redox reaction to 2-hydroxy-2-quinolin-4-yl-malonates 9 was observed. Amination of 3-nitroquinolinyl malonate 3f leads to

  4-氯或4-甲苯氧基喹啉1和10与CH酸性化合物反应，例如丙二酸酯2a，b，氰基乙酸乙酯（2c），丙二腈（2d），乙酰乙酸乙酯（2e），乙酰丙酮（2f）或二甲基酮（2g）在温和的条件下，对喹啉-4-基取代的衍生物3-8和11具有良好的收率。用3-苯基磺酰基喹诺酮类化合物1i-k，观察到对2-羟基-2-喹啉-4-基丙二酸酯9的氧化还原反应。3-硝基喹啉基丙二酸酯3f的胺化反应生成马洛酯酰胺13和14。
• Nuclear Order and Disorder
  作者：William Walker

  DOI：10.1111/1468-2346.00160

  日期：2000.10

  After a decade of great progress in diminishing the risks posed by nuclear weapons, international nuclear relations came unstuck in the late 1990s. Why did this happen? This question is best answered through an understanding of how a ‘nuclear order’ was constructed during the Cold War, how it developed in the early post-Cold War period, and how confidence in it dissipated as the 1990s wore on. After considering how the nuclear order was founded upon linked systems of deterrence and abstinence, the article explains how both were destabilized in the mid- to late 1990s—cause and effect of the United States shifting its ordering strategy towards protection (through missile defences) and enforcement. Can confidence in nuclear order be restored? How should we regard the recent agreement among States Parties to the Nuclear Non-Proliferation Agreement to press for complete nuclear disarmament?

  经过十年在减少核武器风险方面取得巨大进展后，国际核关系在 20 世纪 90 年代末陷入困境。为什么会发生这种情况？要回答这个问题，最好的办法是了解“核秩序”在冷战期间是如何构建的、它在冷战后早期是如何发展的，以及人们对它的信心是如何随着 20 世纪 90 年代的流逝而消散的。在考虑了核秩序如何建立在威慑和节制的相互联系的系统之上之后，本文解释了两者如何在 20 世纪 90 年代中后期变得不稳定——美国将其秩序战略转向保护（通过导弹防御）和执法。能否恢复对核秩序的信心？我们应该如何看待《核不扩散协定》缔约国最近达成的敦促全面核裁军的协议？
• Process to produce halo-4-phenoxyquinolines
  申请人：——

  公开号：US20040044217A1

  公开（公告）日：2004-03-04

  The present invention relates to a process for the preparation of halo-4-phenoxyquinolines.

  本发明涉及一种制备卤代4-苯氧基喹啉的方法。
• Regioselective Azidation of 2,4-Dichloroquinolines
  作者：Waltraud Steinschifter、Wolfgang Stadlbauer

  DOI：10.1002/prac.19943360407

  日期：——

  Reactions of 2,4-dichloroquinolines (2a-f) with sodium azide in DMF lead either regioselectively to 4-azido-2-chloroquinolines (3a-f) or with excess of sodium azide and catalysts to 5-azido-tetrazolo[1,5-a]quinolines (4a-f). 2,4-Dichloroquinolines (2g-i) having electron donating substituents in 3-position react with sodium azide in DMF to a mixture of 4-azido-2-chloroquinolines (3g-i) and 5-chloro-tetrazolo[1,5-a]quinolines (5g-i). When the reaction of the 2,4-dichloroquinolines (2a-i) with sodium azide is carried out in ethanol with addition of methanesulfonic acid, regioselectively 5-chloro-tetrazolo[1,5-a]quinolines (5a-i) are obtained. Structural assignments of 3 and 5 have been carried out by C-13-NMR spectra, IR spectra and degradation reactions of the azido- and tetrazolo group to aminoquinolines (7 and 10) via iminophosphoranes (8 and 9). It could be shown that in 2-azido/tetrazolo-quinolines (4 and 5) the tetrazole ring structure is the dominant species.
• Osborne, Alan G.; Buley, Jill M.; Clarke, Helen, Journal of the Chemical Society. Perkin transactions I, 1993, # 22, p. 2747 - 2756
  作者：Osborne, Alan G.、Buley, Jill M.、Clarke, Helen、Dakin, Rachel C. H.、Price, Paul I.

  DOI：——

  日期：——