2,3-双(1-甲基乙基)-丁二酸-1,4-二乙酯 | 33367-55-4

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2,3-双(1-甲基乙基)-丁二酸-1,4-二乙酯
• 中文别名: 2,3-二异丙基丁二酸二乙酯；丁二酸,2,3-双(1-甲基乙基)-1,4-二乙酯
• 英文名称: diethyl 2,3-diisopropylsuccinate
• 英文别名: 2,3-diisopropylsuccinate diethyl ester；Diethyl-α,α'-diisopropylsuccinat；Diethyl-2,3-diisopropylsuccinat；2,3-diisopropyl-succinic acid diethyl ester；2,3-Diisopropyl-bernsteinsaeure-diaethylester；diethyl 2,3-di(propan-2-yl)butanedioate
• CAS: 33367-55-4
• 化学式: C₁₄H₂₆O₄
• 分子量: 258.358
• InChiKey: WGFNXLQURMLAGC-UHFFFAOYSA-N

物化性质

• 沸点：
  262.1±8.0 °C(Predicted)
• 密度：
  0.963±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2917190090

反应信息

• 作为反应物：
  描述：

  2,3-双(1-甲基乙基)-丁二酸-1,4-二乙酯 在 硫酸 作用下， 生成 2,3-diisopropylsuccinic acid
  参考文献：
  名称：

  Benzodiazepines and anterior pituitary function

  摘要：

  Benzodiazepines (BDZ) are one of the most prescribed classes of drugs because of their marked anxiolytic, anticonvulsant, muscle relaxant and hypnotic effects. The pharmacological actions of BDZ depend on the activation of 2 specific receptors. The central BDZ receptor, present in several areas of the central nervous system (CNS), is a component of the GABA-A receptor, the activation of which increases GABAergic neurotransmission and is followed by remarkable neuroendocrine effects. The peripheral benzodiazepine receptors (PBR), structurally and functionally different from the GABA-A receptor, have been shown in peripheral tissues but also in the CNS, in both neurones and glial cells, and in the pituitary gland. BDZ receptors bind to a family of natural peptides called endozepines, firstly isolated from neurons and glial cells in the brain and then in several peripheral tissues as well. Endozelpines modulate several central and peripheral biological activities, including some neuroendocrine functions and synthetic BDZ are likely to mimic them, at least partially. BZD, especially alprazolam (AL), possess a clear inhibitory influence on the activity of the HPA axis in both animals and humans. This effect seems to be mediated at the hypothalamic and/or suprahypothalamic level via suppression of CRH. The strong negative influence of AL on hypothalamic-pituitary-adrenal (HPA) axis agrees with its peculiar efficacy in the treatment of panic disorders and depression. BZD have also been shown to increase GH secretion via mechanisms mediated at the hypothalamic or supra-hypothalamic level, though a pituitary action cannot be ruled out. Besides the impact on HPA and somatotrope function, BDZ also significantly affect the secretion of other pituitary hormones, such as gonadotropins and. PRL, probably acting through GABAergic mediation in the hypothalamus and/or in the pituitary gland. In all, BDZ are likely to represent a useful tool to investigate GABAergic activity and clarify its role in the neuroendocrine control of anterior pituitary function; their usefulness probably overrides what had been supposed before.

  DOI：

  10.1007/bf03345110
• 作为产物：
  描述：

  异戊酸乙酯 在 四氯化钛 、 lithium diisopropyl amide 作用下， 生成 2,3-双(1-甲基乙基)-丁二酸-1,4-二乙酯
  参考文献：
  名称：

  Oxidative Dimerization of Lithium-Enolates of Esters Promoted by TitaniumTetrachloride

  摘要：

  四氯化钛能有效促进锂酯烯醇盐的氧化二聚反应，这一新方法具有高效性。机理研究表明，反应通过类自由基机制进行，但并非自由基过程。

  DOI：

  10.1246/cl.1992.1591

文献信息

• Versatile desilylative cross-coupling of silyl enol ethers and allylic silanes via oxovanadium-induced chemoselective one-electron oxidation
  作者：Toshikazu Hirao、Takashi Fujii、Yoshiki Ohshiro

  DOI：10.1016/s0040-4020(01)81753-1

  日期：1994.8

  The chemoselective cross-coupling of silyl enol ethers and allylic silanes to γ,δ-unsaturated ketones is achieved by the oxovanadium (V)-induced oxidative desilylation of the more readily oxidizable organosilicon compounds.

  甲硅烷基烯醇醚和烯丙基硅烷与γ，δ-不饱和酮的化学选择性交叉偶联是通过氧钒酸（V）诱导的较易氧化的有机硅化合物的氧化脱甲硅基作用实现的。
• ELECTROCHEMICAL OXIDATION OF LITHIUM ESTER ENOLATES
  作者：Masao Tokuda、Tetsuro Shigei、Mitsuomi Itoh

  DOI：10.1246/cl.1975.621

  日期：1975.6.5

  Electrochemical oxidation of lithium enolates of esters containing no activating groups at low temperature produced the corresponding substituted succinate esters in fairly good yields Electrolysis of enolate of ethyl phenylacetate also produced a quantitative yield of the oxidative dimer with 100% current efficiency.

  不含活化基团的酯的烯醇锂在低温下的电化学氧化以相当好的产率产生相应的取代琥珀酸酯。苯乙酸乙酯烯醇的电解也产生了氧化二聚体的定量产率，电流效率为 100%。
• Halogenated Amide Ester and Internal Electron Donor with Same
  申请人：Chen Linfeng

  公开号：US20120322964A1

  公开（公告）日：2012-12-20

  Disclosed are halogenated amide esters that are suitable as internal electron donors in procatalyst compositions. Ziegler-Natta catalyst compositions containing the present procatalyst compositions exhibit improved catalyst activity and/or improved catalyst selectivity and produce propylene-based olefins with broad molecular weight distribution.

  揭示了适用作为内部电子给体的卤代酰胺酯在前催化剂组合物中。含有这种前催化剂组合物的齐格勒-纳塔催化剂组合物表现出改善的催化剂活性和/或改善的催化剂选择性，并生产具有广泛分子量分布的丙烯基烯烃。
• [EN] CATALYST SYSTEM FOR POLYMERISATION OF AN OLEFIN<br/>[FR] SYSTÈME CATALYSEUR POUR LA POLYMÉRISATION D'UNE OLÉFINE
  申请人：SAUDI BASIC IND CORP

  公开号：WO2015022298A1

  公开（公告）日：2015-02-19

  The present invention relates to a catalyst system comprising a procatalyst, a co-catalyst and an external electron donor, wherein the external electron donor comprises a compound having the structure according to Formula I: Si (L)n (OR11)4-n (Formula I), wherein, Si is a silicon atom with valency 4+; O is an oxygen atom with valency 2- and O is bonded to Si via the silicon-oxygen bond; n is 1, 2, 3 or 4; R11 is a selected from the group consisting of linear, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms; L is a group represented by (Formula II), wherein, L is bonded to the silicon atom via the nitrogen-silicon bond; L has a single substituent on the nitrogen atom, where this single substituent is an imine carbon atom; and X and Y are independently selected from the group consisting of a hydrogen atom; a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements; a linear, branched and cyclic alkyl having at most 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements and an aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 7 of the IUPAC Periodic Table of the Elements.

  本发明涉及一种催化剂体系，包括原催化剂、协同催化剂和外部电子供体，其中外部电子供体包括具有以下结构的化合物：Si（L）n（OR11）4-n（式I），其中，Si是具有4价的硅原子；O是具有2价的氧原子，通过硅氧键与Si相连；n为1、2、3或4；R11选自具有最多20个碳原子的线性、支链和环烷基以及具有6至20个碳原子的芳香族取代和未取代的烃基；L是由（式II）表示的一组，其中，L通过氮硅键与硅原子相连；L在氮原子上具有单个取代基，该单个取代基为亚胺碳原子；X和Y分别选自IUPAC元素周期表的13、14、15、16或17族的杂原子、最多含有20个碳原子的线性、支链和环烷基，可以包含来自IUPAC元素周期表的13、14、15、16或17族的杂原子，以及具有6至20个碳原子的芳香族取代和未取代的烃基，可以包含来自IUPAC元素周期表的13、14、15、16或17族的杂原子。
• Synthesis of (arylimido)vanadium complexes and their application for oxidative coupling reactions of silyl enol ether derivatives
  作者：Masafumi Nishina、Toshiyuki Moriuchi、Toshikazu Hirao

  DOI：10.1039/c0dt00633e

  日期：——

  affect the character of the imido nitrogen. The 51V NMR spectroscopic measurements indicated that the electronic state of the vanadium metal centre depends on the ligands connecting to the vanadium and the substituents on the benzene ring. The selective oxidative cross-coupling reaction of silyl ketene acetal with silyl enol ether was achieved using V(Np-BrC6H4)Cl3 or V(No-BrC6H4)Cl3.

  （Arylimido）钒（V） 复合体 V（NAr）（OEt）Cl 2 [氩气＝ C 6 H 5，对-BrC 6 H 4，对-（MeO）C 6 H 4 ]或V（NAr）Cl 3 [氩气＝o -BrC 6 H 4，邻-（MeO）C 6 H 4 ]通过以下反应合成：VO（OEt）Cl 2 或者 VOCl 3分别与相应的芳基异氰酸酯。X射线晶体结构测定V（NAr）（OEt）Cl 2 （氩气= C 6 H 5和p -BrC 6 H 4）阐明了烷氧基桥接的二聚体结构单元[V（NAr）（OEt）Cl 2 ] 2，其中发现苯环上的取代基影响亚氨基氮的特性。的51个V NMR光谱测量表明，钒金属中心的电子状态取决于连接到所述的配位体钒和苯环上的取代基。使用V（N p -BrC 6 H 4）Cl 3或V（N o- BrC 6 H 4）Cl 3进行甲硅烷基乙烯酮缩醛与甲硅烷基烯醇醚的选择性氧化交叉偶联反应。