2,3-diisopropylsuccinic acid | 91007-67-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3-diisopropylsuccinic acid
• 英文别名: racem.-2,3-diisopropyl-succinic acid；racem.-2,3-Diisopropyl-bernsteinsaeure；(+/-)-2,3-Diisopropyl-bernsteinsaeure；meso-2,3-Diisopropyl-bernsteinsaeure；(2R,3R)-2,3-di(propan-2-yl)butanedioic acid
• CAS: 91007-67-9
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: HSCLUIKEZDGKBP-HTQZYQBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3-diisopropylsuccinic acid 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  LV.—烷基取代的琥珀酸的研究。第二部分 小号二丙基，小号二异丙基，和αα 1 -propylisopropyl-琥珀酸

  摘要：

  DOI：

  10.1039/ct9007700654
• 作为产物：
  描述：

  2,3-双(1-甲基乙基)-丁二酸-1,4-二乙酯 在 硫酸 作用下， 生成 2,3-diisopropylsuccinic acid
  参考文献：
  名称：

  Benzodiazepines and anterior pituitary function

  摘要：

  Benzodiazepines (BDZ) are one of the most prescribed classes of drugs because of their marked anxiolytic, anticonvulsant, muscle relaxant and hypnotic effects. The pharmacological actions of BDZ depend on the activation of 2 specific receptors. The central BDZ receptor, present in several areas of the central nervous system (CNS), is a component of the GABA-A receptor, the activation of which increases GABAergic neurotransmission and is followed by remarkable neuroendocrine effects. The peripheral benzodiazepine receptors (PBR), structurally and functionally different from the GABA-A receptor, have been shown in peripheral tissues but also in the CNS, in both neurones and glial cells, and in the pituitary gland. BDZ receptors bind to a family of natural peptides called endozepines, firstly isolated from neurons and glial cells in the brain and then in several peripheral tissues as well. Endozelpines modulate several central and peripheral biological activities, including some neuroendocrine functions and synthetic BDZ are likely to mimic them, at least partially. BZD, especially alprazolam (AL), possess a clear inhibitory influence on the activity of the HPA axis in both animals and humans. This effect seems to be mediated at the hypothalamic and/or suprahypothalamic level via suppression of CRH. The strong negative influence of AL on hypothalamic-pituitary-adrenal (HPA) axis agrees with its peculiar efficacy in the treatment of panic disorders and depression. BZD have also been shown to increase GH secretion via mechanisms mediated at the hypothalamic or supra-hypothalamic level, though a pituitary action cannot be ruled out. Besides the impact on HPA and somatotrope function, BDZ also significantly affect the secretion of other pituitary hormones, such as gonadotropins and. PRL, probably acting through GABAergic mediation in the hypothalamus and/or in the pituitary gland. In all, BDZ are likely to represent a useful tool to investigate GABAergic activity and clarify its role in the neuroendocrine control of anterior pituitary function; their usefulness probably overrides what had been supposed before.

  DOI：

  10.1007/bf03345110

文献信息

• Stereo- and enantioselective polymerization of hexa-1,5-diene on heterogeneous Ziegler-Natta catalysts obtained with the use of optically active internal donors
  作者：A. L. Lyubimtsev、I. E. Nifant’ev

  DOI：10.1007/s11172-009-0231-z

  日期：2009.8

  Pure racemates and individual enantiomers of diethyl 2,3-diisopropylsuccinate ((+,−)-DIPS and (−)-DIPS) and 2,3-diisopropyl-1,4-dimethoxybutane ((+,−)-DPDMB and (+)-DPDMB) were prepared. The synthesized compounds and diethyl phthalate were used as internal donors for the preparation of heterogeneous Ziegler-Natta catalysts. Polymerization of hexa-1,5-diene was carried out on these catalysts. The obtained samples of poly(methylene-1,3-cyclopentane) were studied by 13C NMR spectroscopy and polarimetry. The induction of optical activity to polymer is observed with (−)-DIPS as the internal donor. The induction value makes up 15–20% from the value recorded in the case of optically active metallocene catalysts. The emergence of induction may be associated with the presence of close contact between the titanium atom and the donor molecule within the active site of catalyst, as well as with the fact that the donor molecule either deactivates a part of the stereospecific titanium centers or influences the structure of the titanium centers during their formation and development.

  2,3-二异丙基琥珀酸二乙酯（(+,−)-DIPS 和 (−)-DIPS）和 2,3-二异丙基-1,4-二甲氧基丁烷（(+,−)-DPDMB 和 (+) 的纯外消旋体和单个对映体）-DPDMB）被制备。合成的化合物和邻苯二甲酸二乙酯作为内给体用于制备非均相齐格勒-纳塔催化剂。在这些催化剂上进行了六-1,5-二烯的聚合。通过 13C NMR 光谱和旋光分析对所得聚（亚甲基-1,3-环戊烷）样品进行了研究。使用 (-)-DIPS 作为内给体观察到聚合物的光学活性诱导。诱导值占光学活性茂金属催化剂记录值的 15-20%。诱导的出现可能与催化剂活性位点内钛原子和供体分子之间存在紧密接触有关，也与供体分子使部分立体定向钛中心失活或影响钛原子中心的事实有关。钛中心在其形成和发展过程中的结构。
• Eberson,L., Acta Chemica Scandinavica (1947), 1963, vol. 17, # 5, p. 1196 - 1202
  作者：Eberson,L.

  DOI：——

  日期：——
• Hell; Mayer,W., Chemische Berichte, 1889, vol. 22, p. 50
  作者：Hell、Mayer,W.

  DOI：——

  日期：——
• Benzodiazepines and anterior pituitary function
  作者：E. Arvat、R. Giordano、S. Grottoli、E. Ghigo

  DOI：10.1007/bf03345110

  日期：2002.9

  Benzodiazepines (BDZ) are one of the most prescribed classes of drugs because of their marked anxiolytic, anticonvulsant, muscle relaxant and hypnotic effects. The pharmacological actions of BDZ depend on the activation of 2 specific receptors. The central BDZ receptor, present in several areas of the central nervous system (CNS), is a component of the GABA-A receptor, the activation of which increases GABAergic neurotransmission and is followed by remarkable neuroendocrine effects. The peripheral benzodiazepine receptors (PBR), structurally and functionally different from the GABA-A receptor, have been shown in peripheral tissues but also in the CNS, in both neurones and glial cells, and in the pituitary gland. BDZ receptors bind to a family of natural peptides called endozepines, firstly isolated from neurons and glial cells in the brain and then in several peripheral tissues as well. Endozelpines modulate several central and peripheral biological activities, including some neuroendocrine functions and synthetic BDZ are likely to mimic them, at least partially. BZD, especially alprazolam (AL), possess a clear inhibitory influence on the activity of the HPA axis in both animals and humans. This effect seems to be mediated at the hypothalamic and/or suprahypothalamic level via suppression of CRH. The strong negative influence of AL on hypothalamic-pituitary-adrenal (HPA) axis agrees with its peculiar efficacy in the treatment of panic disorders and depression. BZD have also been shown to increase GH secretion via mechanisms mediated at the hypothalamic or supra-hypothalamic level, though a pituitary action cannot be ruled out. Besides the impact on HPA and somatotrope function, BDZ also significantly affect the secretion of other pituitary hormones, such as gonadotropins and. PRL, probably acting through GABAergic mediation in the hypothalamus and/or in the pituitary gland. In all, BDZ are likely to represent a useful tool to investigate GABAergic activity and clarify its role in the neuroendocrine control of anterior pituitary function; their usefulness probably overrides what had been supposed before.
• LV.—Researches on the alkyl-substituted succinic acids. Part II. s-Dipropyl, s-diisopropyl, and αα₁-propylisopropyl-succinic acids
  作者：William A. Bone、Charles H. G. Sprankling

  DOI：10.1039/ct9007700654

  日期：——