2,5,8,11,14,17,20,23,26,29-十氧杂三十烷 | 27867-19-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,5,8,11,14,17,20,23,26,29-十氧杂三十烷
• 英文名称: nonaethylene glycol dimethyl ether
• 英文别名: 2,5,8,11,14,17,20,23,26,29-Decaoxatriacontane；1-methoxy-2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethane
• CAS: 27867-19-2
• 化学式: C₂₀H₄₂O₁₀
• 分子量: 442.547
• InChiKey: FDXQLPHYJKXLSO-UHFFFAOYSA-N

物化性质

• 沸点：
  476.3±40.0 °C(Predicted)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  30
• 可旋转键数：
  27
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  92.3
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  2,5,8,11,14,17,20,23,26,29-十氧杂三十烷 在 sodium picrate 作用下， 以 甲苯 为溶剂， 生成 nonaethylene glycol dimethyl ether and sodium picrate complex
  参考文献：
  名称：

  冠醚、甘醇二甲醚和多胺对甲苯中的苦味酸碱的亲和力。聚合物负载的线性聚醚的应用

  摘要：

  Mesure des valeurs des constantes de stabilite。Les ethers monomethyliques desglycos semblent etre legerement meilleurs complexants des alcalins que les glymes 通讯员

  DOI：

  10.1021/ja00325a013
• 作为产物：
  描述：

  nonaethylene glycol dimethyl ether and sodium picrate complex 在 RG₇ 作用下， 以 甲苯 为溶剂， 生成 2,5,8,11,14,17,20,23,26,29-十氧杂三十烷 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  冠醚、甘醇二甲醚和多胺对甲苯中的苦味酸碱的亲和力。聚合物负载的线性聚醚的应用

  摘要：

  Mesure des valeurs des constantes de stabilite。Les ethers monomethyliques desglycos semblent etre legerement meilleurs complexants des alcalins que les glymes 通讯员

  DOI：

  10.1021/ja00325a013

文献信息

• Branched Discreet PEG Constructs
  申请人：Davis Paul D.

  公开号：US20130052130A1

  公开（公告）日：2013-02-28

  Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.

  揭示了一般的和“基本纯净”的分支离散聚乙二醇构建物，可用于连接各种生物活性基团，例如，偏好定位器，以及生物制剂如酶，用于诊断，例如成像，治疗，治疗诊断学和特定于其他应用的基团。在其最简单的中间状态中，分支离散聚乙二醇构建物在一端由一种化学反应性基团“A”终止，该基团与创建“A”的生物材料发生反应，该生物材料是一种生物反应性基团，通过连接到至少两个dPEG含链的分支核心（BC）结束，这些链由实线表示，具有端基团，可以是带电的、非反应性的或可反应的基团，并含有约2至64个dPEG残基。
• Vapor phase soldering using certain perfluorinated polyethers
  申请人：Monsanto Company

  公开号：EP0326539A1

  公开（公告）日：1989-08-02

  A perfluorinated polyether having the formula RfO-(CF₂CF₂O)n-R′f wherein n=3-11 and Rf and Rf′ are perfluroinated C₁-C₅ alkyl radicals is used in vapor phase soldering applications. Especially useful for such applications is perfluoroheptaglyme.

  全氟聚醚具有 RfO-(CF₂-CF₂O)n-R′f，其中 n=3-11 和 Rf 和 Rf′是全氟 C₁-C₅烷基，可用于气相焊接。尤其适用于此类应用的是全氟庚二酸。
• Novel perfluorinated polyethers and process for their preparation
  申请人：Monsanto Company

  公开号：EP0332601A1

  公开（公告）日：1989-09-13

  Perfluorinated polyethers having the formula RfO-(CF₂CF₂O)n-R′f wherein n is an integer of 1-11 and each of Rf and R′f is a perfluorinated C₁-C₅-alkyl radical, dimers of such polyethers and carbon to carbon intra­molecularly coupled cyclic derivatives of such poly­ethers are produced by direct fluorination of the polyethers in an inert solvent. Compositions of the perfluorinated polyethers and their derivatives are useful as functional fluids.

  全氟聚醚，其化学式为 RfO-(CF₂CF₂O)n-R′f 其中 n 为 1-11 的整数，Rf 和 R′f 各为全氟 C₁-C₅-烷基，此类聚醚的二聚体以及此类聚醚的碳-碳分子内偶联环状衍生物是通过在惰性溶剂中直接氟化聚醚制得的。全氟聚醚及其衍生物的组合物可用作功能性液体。
• INHIBITORS OF INV(16) LEUKEMIA
  申请人：The University of Virginia Patent Foundation

  公开号：EP3670509A1

  公开（公告）日：2020-06-24

  This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ∼12% of acute myeloid leukemia (AML). The inv(16) fusion results in expression of the CBFβ-SMMHC fusion protein in the blood cells of afflicted patients. The present invention provides compounds which inhibit the function of both CBFβ and the CBFβ-SMMHC fusion. These compounds block the growth of an inv(16) leukemia cell line as well as increase its apoptosis, while showing minimal effects against non inv(16) cell lines. As a mechanism to develop inhibitors with selectivity for the CBFβ-SMMHC fusion protein, the present invention further provides dimeric derivatives of these compounds which show both increased potency as well as selectivity for CBFβ-SMMHC. These compounds show potent inhibition of an inv(16) leukemia cell line with minimal effects on non inv(16) cell lines. Analysis of the pharmacokinetics of the developed compounds has made it possible to improve the lifetime of the compound in the plasma of mice to a level commensurate with long-term treatment.

  本发明描述了 inv(16) 融合的靶向小分子抑制剂的开发，inv(16) 融合是 12% 的急性髓性白血病（AML）的致病因子。inv（16）融合会导致患者血细胞中表达 CBFβ-SMMHC 融合蛋白。本发明提供了抑制 CBFβ 和 CBFβ-SMMHC 融合蛋白功能的化合物。这些化合物能阻断inv(16)白血病细胞系的生长，并增加其凋亡，同时对非inv(16)细胞系的影响极小。作为开发对 CBFβ-SMMHC 融合蛋白具有选择性的抑制剂的机制，本发明进一步提供了这些化合物的二聚衍生物，它们对 CBFβ-SMMHC 具有更高的效力和选择性。这些化合物对 inv(16) 白血病细胞系具有强效抑制作用，而对非 inv(16) 细胞系的影响极小。通过对所开发化合物的药代动力学分析，可以将化合物在小鼠血浆中的存活时间延长到与长期治疗相称的水平。
• COMPOSITION COMPRISING ORGANOBORATES AND PHYSICAL SOLVENTS AND USE THEREOF FOR THE REMOVAL OF ACID GASES FROM HYDROCARBON FLUID STREAMS
  申请人：Dow Global Technologies, LLC

  公开号：EP3442681A1

  公开（公告）日：2019-02-20