2,5-二甲基-己烷-2,3-二醇 | 871877-18-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,5-二甲基-己烷-2,3-二醇
• 英文名称: 2,5-dimethyl-hexane-2,3-diol
• 英文别名: 2,5-Dimethyl-hexan-2,3-diol；2,5-Dimethylhexane-2,3-diol
• CAS: 871877-18-8
• 化学式: C₈H₁₈O₂
• 分子量: 146.23
• InChiKey: DJIWIIXBDIJLAU-UHFFFAOYSA-N

物化性质

• 沸点：
  136-137 °C(Press: 81 Torr)
• 密度：
  0.934±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,5-二甲基-己烷-2,3-二醇 在 硫酸 作用下， 生成 2,5-二甲基-3-己酮
  参考文献：
  名称：

  Kanao; Yaguchi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1928, vol. 48, p. 71

  摘要：

  DOI：
• 作为产物：
  描述：

  异戊醇 、 丙酮 生成 2,5-二甲基-己烷-2,3-二醇
  参考文献：
  名称：

  Sernagiotto, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1919, vol. <5> 28 I, p. 433

  摘要：

  DOI：

文献信息

• Pyridin-2-YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus
  申请人：Aicher Thomas Daniel

  公开号：US20100204240A1

  公开（公告）日：2010-08-12

  Provided are compounds of Formula (I): wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

  提供的化合物式(I)如下：其中R2、R3、R13、L和D2如规范中所定义，这些化合物可用于治疗和/或预防由于葡萄糖激酶活性不足引起或可以通过激活葡萄糖激酶治疗的疾病或紊乱，包括但不限于糖尿病、糖耐量受损、IFG（空腹血糖受损）和IFG（空腹高血糖），以及本文所讨论的其他疾病和紊乱。
• Pyridin-2YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus
  申请人：AICHER Thomas Daniel

  公开号：US20120277242A1

  公开（公告）日：2012-11-01

  Provided are compounds of Formula (I): wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

  本发明提供了式(I)的化合物：其中R2、R3、R13、L和D2如规范中所定义，它们在治疗和/或预防由葡萄糖激酶活性不足介导的疾病或疾病中有用，或者可以通过激活葡萄糖激酶来治疗，包括但不限于糖尿病、糖耐量受损、IFG（空腹血糖受损）和IFG（空腹高血糖），以及其他疾病和疾病，如在此处所讨论的。
• INTERMEDIATES FOR THE PREPARATION OF PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES
  申请人：Array BioPharma Inc.

  公开号：US20150057448A1

  公开（公告）日：2015-02-26

  Provided are intermediates having the formulas wherein R 2 , R 3 , and L are as defined in the specification, which are useful in the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives.

  提供了中间体的公式，其中R2，R3和L的定义如规范中所述，这些中间体在制备吡啶-2-基氨基-1,2,4-噻二唑衍生物中很有用。
• TRIAZOLYL DERIVATIVES AS SYK INHIBITORS
  申请人：MACHACEK Michelle R.

  公开号：US20150239866A1

  公开（公告）日：2015-08-27

  Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

  提供了公式I的三唑衍生物，它们是脾酪氨酸激酶的强效抑制剂和药物组合物。这些三唑衍生物可用于治疗和预防由该酶介导的疾病，如哮喘、COPD、类风湿性关节炎和癌症。
• Method for modifying the permeability of an underground formation
  申请人：Akzo Nobel N.V.

  公开号：EP0474284A1

  公开（公告）日：1992-03-11

  A method is disclosed for reducing the permeability of the more permeable zone of an underground formation having non-uniform permeability, the method comprised of injecting into the formation a blend comprised of an amine oxide and an alcohol, said blend introduced in an amount effective to reduce the permeability of the more permeable zone of the formation. The preferred amine oxide is dimethyltallowamine oxide, delivered in water. The preferred alcohol is isopropanol. The disclosed method may optionally comprise the further step of injecting an alcohol slug following injection of the amine oxide and alcohol blend.

  本发明公开了一种用于降低渗透率不均匀的地下地层中渗透率较高区域的渗透率的方法，该方法包括向地层中注入由氧化胺和醇组成的混合物，所述混合物的引入量可有效降低地层中渗透率较高区域的渗透率。首选的氧化胺是二甲基氧化锡胺，在水中输送。优选的醇是异丙醇。所公开的方法可以选择性地包括在注入氧化胺和酒精混合物之后注入酒精的进一步步骤。