2,5-双(4-甲氧基苯基)吡嗪 | 24294-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2,5-双(4-甲氧基苯基)吡嗪
• 英文名称: 2,5-bis(4-methoxyphenyl)pyrazine
• CAS: 24294-82-4
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.337
• InChiKey: QEUDPICOWDVQTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,5-双(4-甲氧基苯基)吡嗪 在 氢碘酸 、 溶剂黄146 作用下， 生成 2-amino-1-(4-hydroxy-phenyl)-ethanone; hydriodide
  参考文献：
  名称：

  Tutin, Journal of the Chemical Society, 1910, vol. 97, p. 2520

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4-methoxyphenacyl)-2,6-dimethylisonicotinamide 在 氯化亚砜 作用下， 反应 3.0h， 以27 mg的产率得到2,5-双(4-甲氧基苯基)吡嗪
  参考文献：
  名称：

  Hall, J. Herbert; Chien, Joseph Yuming; Kauffman, Joel M., Journal of Heterocyclic Chemistry, 1992, vol. 29, # 5, p. 1245 - 1273

  摘要：

  DOI：

文献信息

• Microwave-assisted synthesis of α-hydroxy ketone and α-diketone and pyrazine derivatives from α-halo and α,α′-dibromo ketone
  作者：Takamitsu Utsukihara、Hiroaki Nakamura、Masashige Watanabe、C. Akira Horiuchi

  DOI：10.1016/j.tetlet.2006.10.087

  日期：2006.12

  A novel reaction of α-halo ketone (α-bromo and α-chloro ketone) with irradiation under microwave gave the corresponding α-hydroxyketone and pyrazine derivative in good yields. In the case of α,α′-dibromo ketone, α-diketone was obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxyketone, α-diketone, α-chloro ketone and pyrazine derivative.

  微波辐射下α-卤代酮（α-溴代和α-氯代酮）的新型反应可得到相应的α-羟基酮和吡嗪衍生物，收率很高。在α，α′-二溴酮的情况下，获得了α-二酮。该反应为α-羟基酮，α-二酮，α-氯酮和吡嗪衍生物的合成提供了一种新的，清洁且方便的方法。
• Diarylpyrazine-based position isomers: A detailed study of optical properties and structure-property relationship
  作者：Dong-Jin Park、Puttavva Meti、Young-Dae Gong

  DOI：10.1016/j.dyepig.2020.108254

  日期：2020.5

  A versatile and expeditious synthetic route to pyrazine-based symmetric and asymmetric chromophores decorated with donor-acceptor (D-A) has been designed to study their structural effects on optical properties. Suzuki-Miyaura coupling of dihalopyrazine with various aryl boronic acids was synthesized under microwave condition. Pyrazine functionalized at C-2, C-5 and C-6 serve as acceptor to construct

  设计了一种通用且快速的合成路线，以吡嗪为基的对称和不对称生色团装饰有供体-受体（DA），以研究其对光学性质的结构影响。在微波条件下合成了二卤代吡嗪与各种芳基硼酸的Suzuki-Miyaura偶联。在C-2，C-5和C-6上官能化的吡嗪用作受体，以构建线性和角推挽生色团。系统地研究了所有目标发色团的光物理，电化学和热性质，并通过密度泛函理论计算将结果与理论相关。通过引入强电子吸收基团（CN），发射波长显着红移。末端供体受体单元的排列以可预测的方式调节光电性能，有助于合理设计发光材料的小分子。这些生色团在不同的溶剂中表现出多色变化，表现出良好的溶剂变色性，斯托克斯位移较大。
• Highly efficient synthesis of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates
  作者：Zhengwang Chen、Dongnai Ye、Guohai Xu、Min Ye、Liangxian Liu

  DOI：10.1039/c3ob41164h

  日期：——

  A highly efficient synthesis of a wide range of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates is described. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in moderate to excellent yields with a broad substrate scope, including a variety of aromatic and aliphatic haloenol acetates.

  描述了一种高效合成多种2,5-二取代吡嗪的方法，该方法源自(Z)-β-卤烯醇醋酸酯。在便利的条件下进行反应，所产物具有优异的区域选择性，产率中等至优秀，并且适用范围广泛，包括多种芳香族和脂肪族卤烯醇醋酸酯。
• New utilities of tricyclic compounds
  申请人：Ishizuka Natsuki

  公开号：US20080318958A1

  公开（公告）日：2008-12-25

  Pharmaceutical compositions for enhancing the expression of apoAI are provided, which are used as medicaments for treatment of cardiovascular diseases on the basis of improving the functions of HDL. Pharmaceutical compositions for enhancing the expression of apoAI which comprises a compound of formula (I): in which X 1 and X 1 are independently an aryl or heteroaryl that may be optionally substituted, a hydrogen, a halogen, or the like; ring A is a benzene ring or 6-membered aromatic heterocyclic ring containing 1 to 3 N atoms that may be optionally condensed with another aromatic ring; R 1 to R 4 are independently a hydrogen, a halogen, a lower alkyl, a lower alkoxy or the like; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them are disclosed.

  提供用于增强apoAI表达的药物组合物，用于改善HDL功能，作为治疗心血管疾病的药物。药物组合物用于增强apoAI表达，其中包括式(I)的化合物：其中X1和X2独立地是芳基或杂芳基，可以选择性地被取代，氢，卤素等；环A是苯环或含有1至3个N原子的6元芳杂环，可以选择性地与另一个芳香环融合；R1至R4独立地是氢，卤素，低碳基，低碳氧基或类似物；其前药，药学上可接受的盐或溶剂也被披露。
• Utsukihara, Takamitsu; Koshimura, Masahiro; Kitsuta, Kazunori, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 12, p. 1495 - 1502
  作者：Utsukihara, Takamitsu、Koshimura, Masahiro、Kitsuta, Kazunori、Sato, Akinori、Matsushita, Masatoshi、Takahashi, T. Tomoyoshi、Horiuchi, C. Akira

  DOI：——

  日期：——