2,6-二甲基庚烷-3,4-二酮 | 1011726-87-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,6-二甲基庚烷-3,4-二酮
• 英文名称: 2,6-dimethylheptane-3,4-dione
• CAS: 1011726-87-6
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: KYZVJFJOZPKDEF-UHFFFAOYSA-N

物化性质

• 沸点：
  183.4±9.0 °C(Predicted)
• 密度：
  0.907±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-dimethylhept-3-yne-2,5-diol 在 4-二甲氨基吡啶 、 [(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)Au(NTf₂)] 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 2,6-二甲基庚烷-3,4-二酮
  参考文献：
  名称：

  Diversity-Oriented Synthesis of a Library of Star-Shaped 2H-Imidazolines

  摘要：

  A library of star-shaped 2H-imidazolines has been synthesized via Debus Radziszewski condensation from 1,2-diketones and ketone starting materials. Selective reduction of one imine group of the 2H-imidazole intermediate with LiAlH4 or catalytic flow hydrogenation furnished 2H-imidazolines, which could be conveniently diversified by reacting the amine N with electrophiles, resulting in a set of 21 amide-, carbamate-, urea-, and allylamine-containing products. In total, five points of diversification could be used, which allow the production of a set of functionally diverse compounds. The synthesis of acylated 2H-imidazolidines resulted in intrinsically labile compounds, which spontaneously degraded to acyclic derivatives, as shown for the reaction of 2H-imidazolidine with hexylisocyanate.

  DOI：

  10.1021/acscombsci.5b00107

文献信息

• CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：US20150297738A1

  公开（公告）日：2015-10-22

  The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

  本发明涉及一种羟烷基淀粉共轭物及其制备方法，所述羟烷基淀粉共轭物包括羟烷基淀粉衍生物和细胞毒性药剂，所述细胞毒性药剂包括至少一个次级羟基，其中羟烷基淀粉通过所述次级羟基与细胞毒性药剂连接。根据本发明的共轭物具有以下公式HAS'(-L-M)n的结构，其中M是细胞毒性药剂的残基，L是连接基团，HAS'是羟烷基淀粉衍生物的残基，n大于或等于1，且羟烷基淀粉衍生物的平均分子量（MW）高于肾脏阈值。
• Gold-Catalyzed Stereocontrolled Synthesis of 2,3-Bis(acetoxy)-1,3-dienes
  作者：Xiaogen Huang、Teresa de Haro、Cristina Nevado

  DOI：10.1002/chem.200900391

  日期：2009.6.8

  the stereochemistry: 2,3‐Bis(acetoxy)‐1,3‐dienes are obtained in a stereocontrolled manner by a novel tandem 1,2‐/1,2‐bis(acetoxy) rearrangement (see scheme, R1 and R2 are δ+ stabilizing). Upon stabilization of the reaction intermediates, the ligand attached to gold controls the stereochemistry of the alkene in the second acetate migration, that is, N‐heterocyclic carbenes (NHC) favor cis alkenes, whereas

  改变配体，改变立体化学：通过新的串联1,2- / 1,2-双（乙酰氧基）重排以立体控制方式获得2,3-双（乙酰氧基）-1,3-二烯（参见方案， R 1和R 2为δ +稳定化。反应中间体稳定后，与金连接的配体控制了第二次乙酸盐迁移过程中烯烃的立体化学，即N-杂环卡宾（NHC）有利于顺式烯烃，而膦配体则选择性地提供了反式烯烃。
• Compositions and Methods for Fermentation of Biomass
  申请人：Parekh Sarad

  公开号：US20100268000A1

  公开（公告）日：2010-10-21

  In one aspect, this invention relates to production of useful fermentation end-products from biomass through simultaneous hydrolysis and fermentation by a microorganism, such as Clostridium phytofermentans . The invention also relates to the development of a process for efficient pretreatment and conversion of lignocellulosic biomass to end-products with high conversion efficiency (yield). In another aspect, methods for producing a fermentation end-product by fermenting hexose (C6) and pentose (C5) sugars with a microorganism, such as Clostridium phytofermentans are disclosed herein.

  在一个方面，这项发明涉及通过微生物（如植物发酵槽菌）的同时水解和发酵，从生物质中生产有用的发酵终产物。该发明还涉及开发一种高效预处理和转化木质纤维素生物质为高转化效率（产率）的终产物的过程。在另一个方面，本文介绍了利用微生物（如植物发酵槽菌）发酵己糖（C6）和戊糖（C5）糖产生发酵终产物的方法。
• Gold-Catalyzed 1,2-/1,2-Bis-acetoxy Migration of 1,4-Bis-propargyl Acetates: A Mechanistic Study
  作者：Teresa de Haro、Enrique Gómez-Bengoa、Riccardo Cribiú、Xiaogen Huang、Cristina Nevado

  DOI：10.1002/chem.201103472

  日期：2012.5.29

  The late transition metal catalyzed rearrangement of propargyl acetates offers an interesting platform for the development of synthetically useful transformations. We have recently shown that gold complexes can catalyze a highly selective tandem 1,2‐/1,2‐bis‐acetoxy migration in 1,4‐bis‐propargyl acetates to form 2,3‐bis‐acetoxy‐1,3‐dienes. In this way, (1Z,3Z)‐ or (1Z,3E)‐ and (1E,3Z)‐1,3‐dienes could

  晚期炔丙基乙酸酯的过渡金属催化重排为开发有用的转化提供了有趣的平台。我们最近发现，金络合物可以催化1,4-双炔丙基乙酸酯中的高选择性串联1,2- / 1,2-双乙酰氧基迁移，形成2,3-双乙酰氧基-1,3-二烯。这样，（1 Z，3 Z）‐或（1 Z，3 E）‐和（1 E，3 Z）-1,3-二烯可以立体控制方式获得，具体取决于与金结合的辅助配体的电子和空间特征以及在炔丙基位置的取代基。在这项工作中，我们报告了对该转化范围的实验研究，并对反应机理进行了详细的理论考察，从而揭示了导致反应立体选择性的关键特征。也已经设计出了用于一锅合成喹喔啉杂环和串联Diels-Alder工艺的合成应用。
• BIOFUEL PRODUCTION
  申请人：Yoshikuni Yasuo

  公开号：US20090139134A1

  公开（公告）日：2009-06-04

  Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same.

  提供了用于将多糖转化为适当的单糖或寡糖的方法、酶、重组微生物和微生物系统，例如从生物质中提取的多糖。同时提供了将适当的单糖或寡糖转化为商品化学品，如生物燃料的方法。本文描述的方法生产的商品化学品也提供了。此外，还提供了商品化学品富集的、精炼生产的石油产品，以及生产这些产品的方法。