2-(1H-咪唑-2-基)-1-甲基-咪唑 | 37570-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(1H-咪唑-2-基)-1-甲基-咪唑
• 英文名称: 1-Methyl-2,2'-biimidazol
• 英文别名: 1-Methyl-1H,1'H-2,2'-biimidazole；2-(1H-imidazol-2-yl)-1-methylimidazole
• CAS: 37570-85-7
• 化学式: C₇H₈N₄
• mdl: MFCD00728037
• 分子量: 148.167
• InChiKey: ARMMGWZEBIQBPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  2-(1H-咪唑-2-基)-1-甲基-咪唑 在 sodium hydride 、 一水合肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 27.0h， 生成 N-(6-aminohexyl)-N'-methyl-2,2'-biimidazole
  参考文献：
  名称：

  Long Tethers Binding Redox Centers to Polymer Backbones Enhance Electron Transport in Enzyme “Wiring” Hydrogels

  摘要：

  A redox hydrogel with an apparent electron diffusion coefficient (D-app) of (5.8 +/- 0.5) x 10(-6) cm(2) s(-1) is described. The order of magnitude increase in D-app relative to previously studied redox hydrogels results from the tethering of redox centers to the backbone of the cross-linked redox polymer backbone through 13 atom spacer arms. The long and flexible tethers allow the redox centers to sweep electrons from large-volume elements and to collect electrons of glucose oxidase efficiently. The spacer arms make the collection of electrons from glucose oxidase so efficient that glucose is electrooxidized already at -0.36 V versus Ag/AgCl, the reversible potential of the redox potential of the FAD/FADH(2) centers of the enzyme at pH 7.2. The limiting current density of 1.15 mA cm(-2) is reached at a potential as low as -0.1 V versus Ag/AgCl. The novel redox center of the polymer is a tris-dialkylated N,/\r-biimidazole Os2+/3+ complex. Its redox potential, -0.195 V versus Ag/AgCl, is 0.8 V reducing relative to that of Os(bpy)(2+/3+), its 2,2'-bipyridine analogue.

  DOI：

  10.1021/ja029510e
• 作为产物：
  描述：

  联咪唑 、 硫酸二甲酯 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以0.45 g的产率得到2-(1H-咪唑-2-基)-1-甲基-咪唑
  参考文献：
  名称：

  Mansingh, P. S.; Mohanty, R. R.; Jena, S., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1995, vol. 34, # 8, p. 639 - 642

  摘要：

  DOI：

文献信息

• 一种N-(6-氨己基)-N’-甲基-2,2’-联咪唑的合成方法
  申请人：华东数字医学工程研究院

  公开号：CN110734405A

  公开（公告）日：2020-01-31

  本发明提供了一种N‑(6‑氨己基)‑N’‑甲基‑2,2’‑联咪唑的合成方法，其特征在于，所述方法包括如下步骤：(1)N‑Boc‑6‑卤代己胺和1‑甲基‑1H,1’H‑[2,2’]联咪唑在碱的作用下，反应得到中间体N‑(6‑Boc‑氨己基)‑N’‑甲基‑2,2’‑联咪唑，所述的卤为氯、溴或碘；(2)N‑(6‑Boc‑氨己基)‑N’‑甲基‑2,2’‑联咪唑在酸的作用下反应得到产物N‑(6‑氨己基)‑N’‑甲基‑2,2’‑联咪唑；反应路线如下： 本发明的合成方法反应条件更温和，易操作，且不需用到易燃的氢化钠和易制爆的剧毒品水合肼，操作更加安全，反应路线更绿色环保，同时本发明的合成路线反应收率高，两步反应的收率均在80％以上。
• Inhibitors of c-fms kinase
  申请人：Illig R. Carl

  公开号：US20060100201A1

  公开（公告）日：2006-05-11

  The invention relates to compounds of Formula I: wherein A, X, R 2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

  本发明涉及公式I的化合物：其中A、X、R2和W在说明书中设置，以及其溶剂化物、水合物、互变异构体和药学上可接受的盐，它们抑制蛋白酪氨酸激酶，特别是c-fms激酶。本发明还提供了利用公式I的化合物治疗自身免疫性疾病和具有炎症成分的疾病；治疗卵巢癌、子宫癌、乳腺癌、结肠癌、胃癌、毛细胞白血病和非小细胞肺癌的转移；以及治疗疼痛，包括肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏、炎症和神经性疼痛；以及骨质疏松症、Paget病和其他骨吸收介导的疾病，包括关节炎、假体失效、骨溶性肉瘤、骨髓瘤和肿瘤转移至骨骼。
• Enzyme Electrode, and Device, Sensor, Fuel Cell and Electrochemical Reactor Employing the Enzyme Electrode
  申请人：Kubo Wataru

  公开号：US20080248354A1

  公开（公告）日：2008-10-09

  An enzyme electrode has a conductive member and an enzyme, wherein the conductive member has a porous structure, and the enzyme is immobilized through a carrier in pores constituting the porous structure. An enzyme electrode device, comprises the enzyme electrode, and wiring connected to the conductive member of the enzyme electrode.

  一种酶电极具有导电成员和酶，其中导电成员具有多孔结构，并且通过载体在构成多孔结构的孔中固定酶。一种酶电极装置，包括酶电极和连接到酶电极导电成员的布线。
• Enzyme electrode sensor fuel cell and electrochemical reactor
  申请人：Kubo Wataru

  公开号：US20070056852A1

  公开（公告）日：2007-03-15

  An enzyme electrode comprises a conductive member and an enzyme, wherein a first mediator and a second mediator are immobilized by a carrier onto the conductive member, the first mediator and the second mediator having different redox potentials (reduction-oxidation potentials). A sensor employs the enzyme electrode as a detection portion for detecting a substance. A fuel cell employs the enzyme electrode as at least one of anode and a cathode. An electrochemical reactor employs the enzyme electrode as a reaction electrode.

  一种酶电极包括一个导电成员和一个酶，其中第一介质和第二介质通过载体固定在导电成员上，第一介质和第二介质具有不同的氧化还原电位。一种传感器采用酶电极作为检测部分来检测物质。一种燃料电池采用酶电极作为阳极和/或阴极。一种电化学反应器采用酶电极作为反应电极。
• Redox Polymers
  申请人：Mao Fei

  公开号：US20110303538A1

  公开（公告）日：2011-12-15

  Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.

  介绍了铁、钴、钌、锇和钒的新型过渡金属配合物。这些过渡金属配合物可用作酶基电化学传感器中的氧化还原媒介物。在这种情况下，过渡金属配合物可以以高速从酶中接受电子，或将电子转移给酶，并且还可以与传感器快速交换电子。这些过渡金属配合物包括至少一个取代或未取代的双咪唑配体，并且可能还包括第二个取代或未取代的双咪唑配体或取代或未取代的联吡啶或吡啶咪唑配体。还介绍了连接到聚合物骨架上的过渡金属配合物。