2-(2,3-二甲氧基苯基)-4,5-二苯基-1H-咪唑 | 106436-89-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(2,3-二甲氧基苯基)-4,5-二苯基-1H-咪唑
• 英文名称: 2-(2,3-dimethoxyphenyl)-4,5-diphenyl-1H-imidazole
• CAS: 106436-89-9
• 化学式: C₂₃H₂₀N₂O₂
• 分子量: 356.424
• InChiKey: SDULCAFJIMGOQE-UHFFFAOYSA-N

物化性质

• 沸点：
  565.8±50.0 °C(Predicted)
• 密度：
  1.169±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  47.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  联苯甲酰 、 2,3-二甲氧基苯甲醛 在 ammonium acetate 作用下， 反应 3.33h， 以70%的产率得到2-(2,3-二甲氧基苯基)-4,5-二苯基-1H-咪唑
  参考文献：
  名称：

  A Convenient Method for the Preparation of 2,4,5-triaryl Imidazoles Using Barium Chloride Dispersed on Silica Gel Nanoparticles (BaCl2-nano SiO2) as Heterogeneous Reusable Catalyst

  摘要：

  描述了一种简单且环保的方法，通过使用分散在硅胶纳米颗粒上的氯化钡（BaCl2-nano SiO2）作为高产率的可重复使用的异相催化剂，在热条件下合成2,4,5-三芳基咪唑。

  DOI：

  10.2174/157017812801264683

文献信息

• Fe₃O₄@SiO₂·HM·SO₃H as a recyclable heterogeneous nanocatalyst for the microwave-promoted synthesis of 2,4,5-trisubstituted imidazoles under solvent free conditions
  作者：Hossein Naeimi、Dorsa Aghaseyedkarimi

  DOI：10.1039/c5nj01273b

  日期：——

  synthesis of 2,4,5-trisubstituted imidazoles is achieved through a three component one pot reaction of benzil, benzaldehyde and NH4OAc. This reaction has been catalyzed by Fe3O4@SiO2·HM·SO3H, a very efficient, novel recyclable heterogeneous catalyst, under microwave irradiation and solvent free conditions. The catalyst can be recovered for the subsequent reactions and reused for at least five rounds

  通过苯甲腈，苯甲醛和NH 4 OAc的三组分一锅反应，可以简单，高度通用和高效地合成2,4,5-三取代的咪唑。Fe 3 O 4 @SiO 2 ·HM·SO 3 H是一种非常有效的新型可循环多相催化剂，在微波辐射和无溶剂条件下催化了该反应。可以将催化剂回收用于随后的反应，并重复使用至少五轮，而不会明显降低其效率。
• ZrO₂-β-cyclodextrin catalyzed synthesis of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles under solvent free conditions and evaluation of their antibacterial study
  作者：Yarabhally R. Girish、Kothanahally S. Sharath Kumar、Kuntebommanahalli N. Thimmaiah、Kanchugarakoppal S. Rangappa、Sheena Shashikanth

  DOI：10.1039/c5ra13891d

  日期：——

  A series of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles catalyzed by ZrO₂-supported-β-cyclodextrin (ZrO₂-β-CD) under solvent free conditions have been synthesized and characterized by spectral methods.

  通过ZrO₂支持的β-环糊精（ZrO₂-β-CD）催化的一系列2,4,5-三取代咪唑和1,2-二取代苯并咪唑在无溶剂条件下合成，并通过光谱方法进行了表征。
• Ionophore silica-coated magnetite nanoparticles as a recyclable heterogeneous catalyst for one-pot green synthesis of 2,4,5-trisubstituted imidazoles
  作者：Hossein Naeimi、Dorsa Aghaseyedkarimi

  DOI：10.1039/c5dt03488d

  日期：——

  Novel multi-SO3H functionalized strong Brønsted acidic ionic liquid coated magnetite nanoparticles have been prepared and applied as catalyst for the synthesis of 2,4,5-trisubstituted imidazoles. The results showed that a novel catalyst was very efficient for the reaction and could be magnetically separated and reused at least 6 times with less reduction in its catalytic activity. Operational simplicity

  新型multi-SO 3已经制备了H官能化的强布朗斯台德酸性离子液体涂覆的磁铁矿纳米颗粒，并将其用作合成2,4,5-三取代的咪唑的催化剂。结果表明，新型催化剂对反应非常有效，并且可以磁分离并重复使用至少6次，而催化活性降低得更少。该方法的最重要特征是操作简便，所用催化剂的成本低，产率高，环境友好，适用性广，可重复使用性好以及使用外磁体容易回收催化剂。通过傅里叶变换红外光谱（FT-IR），X射线衍射分析（XRD），场发射扫描电子显微镜（FE-SEM），能量色散X射线分析（EDX）对催化剂进行了表征
• Preparation and Characterization of NiCoFe2O4 Nanoparticles as an Effective Catalyst for the Synthesis of Trisubstituted Imidazole Derivatives Under Solvent-free Conditions
  作者：Leila Hemmesi

  DOI：10.17344/acsi.2022.7633

  日期：——

  In this study, NiCoFe2O4 nanoparticles were prepared and used as a reactive catalyst for the synthesis of trisubstituted imidazoles. The multicomponent reactions of aromatic aldehydes, benzil and ammonium acetate were carried out under solvent-free and conventional heating conditions. In this reaction, some imidazole derivatives with high purity, short reaction times and high yields were obtained.

  在这项研究中，制备了NiCoFe2O4纳米颗粒并将其用作合成三取代咪唑的反应催化剂。芳香醛、苯偶酰和乙酸铵的多组分反应在无溶剂和常规加热条件下进行。该反应得到了一些纯度高、反应时间短、收率高的咪唑衍生物。通过FT-IR、XRD、EDX、VSM和SEM技术对制备的纳米催化剂进行了表征。此外，通过熔点、FT-IR和1H NMR分析鉴定了有机产物。
• Maddheshiya, Ashok; Chawla, Pooja, Indian Journal of Heterocyclic Chemistry, 2018, vol. 28, # 3, p. 423 - 427
  作者：Maddheshiya, Ashok、Chawla, Pooja

  DOI：——

  日期：——