N-[[5-[[(2-methylquinolin-4-yl)amino]methyl]piperidin-2-yl]methyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[[5-[[(2-methylquinolin-4-yl)amino]methyl]piperidin-2-yl]methyl]benzenesulfonamide
• 化学式: C₂₃H₂₈N₄O₂S
• 分子量: 424.6
• InChiKey: OTXZMGLJOGLPRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  91.5
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] PYRIDO' 1,2-ALPHA PYRAZINE AND PIPERIDINE DERIVATIVES AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR<br/>[FR] DERIVES DE PYRIDO' 1,2-ALPHA PYRAZINE ET DE PIPERIDINE SERVANT DE LIGANDS AU RECEPTEUR DE NEUROPEPTIDE Y Y5
  申请人：ASTRAZENECA AB

  公开号：WO2001085730A1

  公开（公告）日：2001-11-15

  Compounds of formula (I) R1—A—R2 wherein R1 and R2 are selected from the following combinations: R1 is R4 —and R2 is —SO2 —R5, R1 is R4 —SO2— and R2 is—R5, R1 is R5— and R2 is—SO2—R4; and R1 is R5—SO2—and R2 is—R4; A is selected from Group 1a, Group 1b, Group 1c or Group 1d and B, R3, R4, R5, p, q and n are as described within, and their pharmaceutically-acceptable salts, pro-drugs and solvates are described. Also described are processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor.