摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

2-(3-氯苯氧基)-6-羟基苯乙酮 | 105277-74-5

中文名称
2-(3-氯苯氧基)-6-羟基苯乙酮
中文别名
——
英文名称
2-(3-chlorophenoxy)-6-hydroxyacetophenone
英文别名
2-(3-chloropropoxy)-6-hydroxyacetophenone;6'-(3-chloropropoxy)-2'-hydroxy-acetophenone;1-[2-(3-chloropropoxy)-6-hydroxyphenyl]ethanone
2-(3-氯苯氧基)-6-羟基苯乙酮化学式
CAS
105277-74-5
化学式
C11H13ClO3
mdl
——
分子量
228.675
InChiKey
ONXYHYBXPRUQMN-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.7
  • 重原子数:
    15
  • 可旋转键数:
    5
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.36
  • 拓扑面积:
    46.5
  • 氢给体数:
    1
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    参考文献:
    名称:
    4H-1-benzopyran-4-ones and their sulfur containing analogs
    摘要:
    揭示了一种有效治疗精神病,包括精神分裂症的Novel 4H-1-苯并吡喃-4-酮及其含硫类似物。
    公开号:
    US04678787A1
  • 作为产物:
    描述:
    2,6-二羟基苯乙酮1-溴-3-氯丙烷potassium carbonate 作用下, 以 N,N-二甲基甲酰胺 为溶剂, 反应 4.0h, 以46%的产率得到2-(3-氯苯氧基)-6-羟基苯乙酮
    参考文献:
    名称:
    [EN] NOVEL OXIME DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
    [FR] NOUVEAUX DÉRIVÉS D'OXIMES ET LEUR UTILISATION COMME MODULATEURS ALLOSTÉRIQUES DE RÉCEPTEURS MÉTABOTROPIQUES DU GLUTAMATE
    摘要:
    本发明提供了一般式(I)的新羟肟衍生物,包含它们的药物组合物以及它们用于治疗和/或预防与改变的谷氨酸信号和/或功能有关的疾病,和/或在哺乳动物中改变谷氨酸水平或信号会影响的疾病。本发明进一步提供了一般式(I)的新羟肟衍生物,它们是对谷氨酸敏感的神经系统受体的调节剂,因此特别适用于治疗和/或预防急性和慢性神经和/或精神障碍。在特定实施例中,本发明的新羟肟衍生物是代谢型谷氨酸受体(mGluRs)的调节剂。本发明还提供了mGluRs的正向变构调节剂,更具体地说是mGluR4的正向变构调节剂。
    公开号:
    WO2011051478A1
点击查看最新优质反应信息

文献信息

  • [EN] NOVEL OXIME DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS<br/>[FR] NOUVEAUX DÉRIVÉS D'OXIMES ET LEUR UTILISATION COMME MODULATEURS ALLOSTÉRIQUES DE RÉCEPTEURS MÉTABOTROPIQUES DU GLUTAMATE
    申请人:DOMAIN THERAPEUTICS
    公开号:WO2011051478A1
    公开(公告)日:2011-05-05
    The present invention provides new oxime derivatives of the general formula (I), pharmaceutical compositions containing them and their use for the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals. This invention further provides new oxime derivatives of the general formula (I) consisting of modulators of nervous system receptors sensitive to glutamate, which makes them particularly suitable for the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders. In particular embodiments, the new oxime derivatives of the invention are modulators of metabotropic glutamate receptors (mGluRs). The invention further provides positive allosteric modulators of mGluRs and more specifically positive alSosteric modulators of mGiuR4.
    本发明提供了一般式(I)的新羟肟衍生物,包含它们的药物组合物以及它们用于治疗和/或预防与改变的谷氨酸信号和/或功能有关的疾病,和/或在哺乳动物中改变谷氨酸水平或信号会影响的疾病。本发明进一步提供了一般式(I)的新羟肟衍生物,它们是对谷氨酸敏感的神经系统受体的调节剂,因此特别适用于治疗和/或预防急性和慢性神经和/或精神障碍。在特定实施例中,本发明的新羟肟衍生物是代谢型谷氨酸受体(mGluRs)的调节剂。本发明还提供了mGluRs的正向变构调节剂,更具体地说是mGluR4的正向变构调节剂。
  • Pyrimidinedione derivative compounds, method for preparing same, and
    申请人:Mitsui Toatsu Chemicals, Incorporated
    公开号:US05114941A1
    公开(公告)日:1992-05-19
    A pyrimidinedione derivative compound has a basic backbone in which a 4-oxobenzopyran ring group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two nitrogen atoms and one oxygen. The pyrimidinedione derivative is useful for a medical treatment of cardiac arrhythmias.
    一种嘧啶二酮衍生物化合物具有一种基本骨架,其中4-氧基苯并吡喃环团部分和嘧啶二酮部分通过含有至少两个氮原子和一个氧原子的烷基链结合。这种嘧啶二酮衍生物对治疗心律失常具有医疗用途。
  • 4H-1-benzopyran-4-ones and their sulfur containing analogs
    申请人:Warner-Lambert Company
    公开号:US04678787A1
    公开(公告)日:1987-07-07
    Novel 4H-1-benzopyran-4-ones and their sulfur containing analogs are disclosed which are efficacious for the treatment of psychosis including schizophrenia.
    揭示了一种有效治疗精神病,包括精神分裂症的Novel 4H-1-苯并吡喃-4-酮及其含硫类似物。
  • Novel Oxime Derivatives and Their Use As Allosteric Modulators of Metabotropic Glutamate Receptors
    申请人:Schann Stephan
    公开号:US20120277212A1
    公开(公告)日:2012-11-01
    The present invention provides new oxime derivatives of the general formula (I), pharmaceutical compositions containing them and their use for the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals. This invention further provides new oxime derivatives of the general formula (I) consisting of modulators of nervous system receptors sensitive to glutamate, which makes them particularly suitable for the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders. In particular embodiments, the new oxime derivatives of the invention are modulators of metabotropic glutamate receptors (mGluRs). The invention further provides positive allosteric modulators of mGluRs and more specifically positive alSosteric modulators of mGluR4.
    本发明提供了一般式(I)的新的肟衍生物,以及包含它们的制药组合物,以及它们用于治疗和/或预防与改变谷氨酸信号和/或功能相关的疾病和/或与哺乳动物中谷氨酸水平或信号改变有关的疾病的用途。本发明还提供了一般式(I)的新的肟衍生物,它们是对谷氨酸敏感的神经系统受体的调节剂,因此特别适用于治疗和/或预防急性和慢性神经和/或精神障碍。在特定实施例中,本发明的新的肟衍生物是代谢型谷氨酸受体(mGluRs)的调节剂。本发明还提供了mGluRs的正向异构调节剂,更具体地说是mGluR4的正向异构调节剂。
  • Oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
    申请人:Schann Stephan
    公开号:US08962627B2
    公开(公告)日:2015-02-24
    The present invention provides new oxime derivatives of the general formula (I), pharmaceutical compositions containing them and their use for the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals. This invention further provides new oxime derivatives of the general formula (I) consisting of modulators of nervous system receptors sensitive to glutamate, which makes them particularly suitable for the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders. In particular embodiments, the new oxime derivatives of the invention are modulators of metabotropic glutamate receptors (mGluRs). The invention further provides positive allosteric modulators of mGluRs and more specifically positive alSosteric modulators of mGluR4.
    本发明提供了一般式(I)的新的肟衍生物、包含它们的药物组合物以及它们用于治疗和/或预防与改变谷氨酸信号和/或功能有关的疾病和/或可以受到哺乳动物谷氨酸水平或信号改变影响的疾病的用途。本发明还提供了一般式(I)的新的肟衍生物,它们是对谷氨酸敏感的神经系统受体的调节剂,因此特别适用于治疗和/或预防急性和慢性神经系统和/或精神疾病。在特定实施例中,本发明的新的肟衍生物是代谢型谷氨酸受体(mGluRs)的调节剂。本发明还提供了mGluRs的正向变构调节剂,更具体地说是mGluR4的正向变构调节剂。
查看更多